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Integrin α10β1-sele...
Integrin α10β1-selected mesenchymal stem cells reduced hypercoagulopathy in a porcine model of acute respiratory distress syndrome
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- Edström, Dag (author)
- Lund University,Lunds universitet,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Stamcellscentrum (SCC),Avdelningen för stamcellsforskning,Institutionen för laboratoriemedicin,WCMM- Wallenberg center för molekylär medicinsk forskning,Department of Clinical Sciences, Lund,Faculty of Medicine,Stem Cell Center,Division of stem cell research,Department of Laboratory Medicine,WCMM-Wallenberg Centre for Molecular Medicine,Skåne University Hospital
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- Niroomand, Anna (author)
- Lund University,Lunds universitet,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Stamcellscentrum (SCC),Avdelningen för stamcellsforskning,Institutionen för laboratoriemedicin,WCMM- Wallenberg center för molekylär medicinsk forskning,Department of Clinical Sciences, Lund,Faculty of Medicine,Stem Cell Center,Division of stem cell research,Department of Laboratory Medicine,WCMM-Wallenberg Centre for Molecular Medicine,Rutgers Robert Wood Johnson Medical School
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- Stenlo, Martin (author)
- Lund University,Lunds universitet,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Stamcellscentrum (SCC),Avdelningen för stamcellsforskning,Institutionen för laboratoriemedicin,WCMM- Wallenberg center för molekylär medicinsk forskning,Department of Clinical Sciences, Lund,Faculty of Medicine,Stem Cell Center,Division of stem cell research,Department of Laboratory Medicine,WCMM-Wallenberg Centre for Molecular Medicine,Skåne University Hospital
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- Uvebrant, Kristina (author)
- Xintela AB
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- Bölükbas, Deniz A (author)
- Lund University,Lunds universitet,Institutionen för experimentell medicinsk vetenskap,Medicinska fakulteten,Lungbioengineering och regeneration,Forskargrupper vid Lunds universitet,WCMM- Wallenberg center för molekylär medicinsk forskning,Department of Experimental Medical Science,Faculty of Medicine,Lung Bioengineering and Regeneration,Lund University Research Groups,WCMM-Wallenberg Centre for Molecular Medicine
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- Hirdman, Gabriel (author)
- Lund University,Lunds universitet,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Stamcellscentrum (SCC),Avdelningen för stamcellsforskning,Institutionen för laboratoriemedicin,WCMM- Wallenberg center för molekylär medicinsk forskning,Department of Clinical Sciences, Lund,Faculty of Medicine,Stem Cell Center,Division of stem cell research,Department of Laboratory Medicine,WCMM-Wallenberg Centre for Molecular Medicine
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- Broberg, Ellen (author)
- Lund University,Lunds universitet,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Stamcellscentrum (SCC),Avdelningen för stamcellsforskning,Institutionen för laboratoriemedicin,WCMM- Wallenberg center för molekylär medicinsk forskning,Department of Clinical Sciences, Lund,Faculty of Medicine,Stem Cell Center,Division of stem cell research,Department of Laboratory Medicine,WCMM-Wallenberg Centre for Molecular Medicine,Skåne University Hospital
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- Lim, Hooi Ching (author)
- Rutgers Robert Wood Johnson Medical School
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- Hyllén, Snejana (author)
- Lund University,Lunds universitet,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Department of Clinical Sciences, Lund,Faculty of Medicine,Skåne University Hospital
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- Lundgren-Åkerlund, Evy (author)
- Xintela AB
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- Pierre, Leif (author)
- Lund University,Lunds universitet,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Stamcellscentrum (SCC),Avdelningen för stamcellsforskning,Institutionen för laboratoriemedicin,WCMM- Wallenberg center för molekylär medicinsk forskning,Department of Clinical Sciences, Lund,Faculty of Medicine,Stem Cell Center,Division of stem cell research,Department of Laboratory Medicine,WCMM-Wallenberg Centre for Molecular Medicine,Skåne University Hospital
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- Olm, Franziska (author)
- Lund University,Lunds universitet,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Stamcellscentrum (SCC),Avdelningen för stamcellsforskning,Institutionen för laboratoriemedicin,WCMM- Wallenberg center för molekylär medicinsk forskning,Department of Clinical Sciences, Lund,Faculty of Medicine,Stem Cell Center,Division of stem cell research,Department of Laboratory Medicine,WCMM-Wallenberg Centre for Molecular Medicine,Skåne University Hospital
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- Lindstedt, Sandra (author)
- Lund University,Lunds universitet,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Stamcellscentrum (SCC),Avdelningen för stamcellsforskning,Institutionen för laboratoriemedicin,WCMM- Wallenberg center för molekylär medicinsk forskning,Department of Clinical Sciences, Lund,Faculty of Medicine,Stem Cell Center,Division of stem cell research,Department of Laboratory Medicine,WCMM-Wallenberg Centre for Molecular Medicine,Skåne University Hospital
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(creator_code:org_t)
- 2023
- 2023
- English 17 s.
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In: Respiratory Research. - 1465-9921. ; 24:1
- Related links:
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http://dx.doi.org/10... (free)
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https://lup.lub.lu.s...
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https://doi.org/10.1...
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Abstract
Subject headings
Close
- Mesenchymal stem cells (MSCs) have been studied for their potential benefits in treating acute respiratory distress syndrome (ARDS) and have reported mild effects when trialed within human clinical trials. MSCs have been investigated in preclinical models with efficacy when administered at the time of lung injury. Human integrin α10β1-selected adipose tissue-derived MSCs (integrin α10β1-MSCs) have shown immunomodulatory and regenerative effects in various disease models. We hypothesized that integrin α10β1 selected-MSCs can be used to treat a sepsis-induced ARDS in a porcine model when administering cells after established injury rather than simultaneously. This was hypothesized to reflect a clinical picture of treatment with MSCs in human ARDS. 12 pigs were randomized to the treated or placebo-controlled group prior to the induction of mild to moderate ARDS via lipopolysaccharide administration. The treated group received 5 × 10 6 cells/kg integrin α10β1-selected MSCs and both groups were followed for 12 h. ARDS was confirmed with blood gases and retrospectively with histological changes. After intervention, the treated group showed decreased need for inotropic support, fewer signs of histopathological lung injury including less alveolar wall thickening and reduction of the hypercoagulative disease state. The MSC treatment was not associated with adverse events over the monitoring period. This provides new opportunities to investigate integrin α10β1-selected MSCs as a treatment for a disease which does not yet have any definitive therapeutic options.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Lungmedicin och allergi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Respiratory Medicine and Allergy (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Cell- och molekylärbiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Cell and Molecular Biology (hsv//eng)
Keyword
- Animals
- Integrins
- Lung Injury
- Mesenchymal Stem Cell Transplantation
- Mesenchymal Stem Cells
- Respiratory Distress Syndrome/diagnosis
- Retrospective Studies
- Swine
Publication and Content Type
- art (subject category)
- ref (subject category)
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- By the author/editor
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Edström, Dag
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Niroomand, Anna
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Stenlo, Martin
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Uvebrant, Kristi ...
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Bölükbas, Deniz ...
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Hirdman, Gabriel
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Broberg, Ellen
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Lim, Hooi Ching
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Hyllén, Snejana
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Lundgren-Åkerlun ...
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Pierre, Leif
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Olm, Franziska
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Lindstedt, Sandr ...
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Respiratory Medi ...
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Cell and Molecul ...
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Respiratory Rese ...
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Lund University