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WFRF:(Ainsworth Peter J)
 

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LIBRIS Formathandbok  (Information om MARC21)
FältnamnIndikatorerMetadata
00004691naa a2200745 4500
001oai:lup.lub.lu.se:7ba1fc85-c8fe-464a-928f-4a78532d2204
003SwePub
008160918s2008 | |||||||||||000 ||eng|
0247 a https://lup.lub.lu.se/record/7ba1fc85-c8fe-464a-928f-4a78532d22042 URI
0247 a https://doi.org/10.1007/s10552-008-9175-02 DOI
040 a (SwePub)lu
041 a engb eng
042 9 SwePub
072 7a art2 swepub-publicationtype
072 7a ref2 swepub-contenttype
1001 a Kotsopoulos, Joanne4 aut
2451 0a Infertility, treatment of infertility, and the risk of breast cancer among women with BRCA1 and BRCA2 mutations : a case-control study
264 c 2008-05-29
264 1b Springer Science and Business Media LLC,c 2008
300 a 9 s.
520 a BACKGROUND: Women with a breast cancer susceptibility gene 1 (BRCA1) or breast cancer susceptibility gene 2 (BRCA2) mutation are at increased risk for developing breast and ovarian cancer. Various reproductive and hormonal factors have been shown to modify the risk of breast cancer. These studies suggest that estrogen exposure and deprivation are important in the etiology of hereditary cancer. Many patients are interested in the possibility of an adverse effect of fertility treatment on breast cancer risk. It is important to evaluate whether or not infertility per se or exposure to fertility medications increase the risk of breast cancer in genetically predisposed women.METHODS: We conducted a matched case-control study of 1,380 pairs of women with a BRCA1 or BRCA2 mutation to determine if a history of infertility, the use of fertility medications, or undergoing in vitro fertilization (IVF) were associated with and increased the risk of breast cancer.RESULTS: Sixteen percent of the study subjects reported having experienced a fertility problem and 4% had used a fertility medication. Women who had used a fertility medication were not at significantly increased risk of breast cancer (odds ratio [OR] = 1.21; 95% confidence interval [CI] = 0.81-1.82) compared to non-users. Furthermore, there was no risk associated with a history of use of a fertility medication when the subjects were stratified by parity: (OR = 1.29; 95% CI = 0.83-2.01 for nulliparous women and OR = 0.81; 95% CI = 0.30-2.22 for parous women).CONCLUSIONS: The results of this study suggest that the use of fertility medications does not adversely affect the risk of breast cancer among BRCA mutation carriers. Given the small sizes of the exposed subgroups, these findings should be interpreted with caution and confirmatory studies are required.
653 a Adolescent
653 a Adult
653 a Aged
653 a Aged, 80 and over
653 a Breast Neoplasms
653 a Bromocriptine
653 a Case-Control Studies
653 a Clomiphene
653 a Estrogens
653 a Female
653 a Fertility Agents, Female
653 a Genes, BRCA1
653 a Genes, BRCA2
653 a Humans
653 a Infertility
653 a Menotropins
653 a Middle Aged
653 a Multivariate Analysis
653 a Mutation
653 a Risk Factors
653 a Young Adult
7001 a Librach, Clifford L4 aut
7001 a Lubinski, Jan4 aut
7001 a Gronwald, Jacek4 aut
7001 a Kim-Sing, Charmaine4 aut
7001 a Ghadirian, Parviz4 aut
7001 a Lynch, Henry T4 aut
7001 a Moller, Pal4 aut
7001 a Foulkes, William D4 aut
7001 a Randall, Susan4 aut
7001 a Manoukian, Siranoush4 aut
7001 a Pasini, Barbara4 aut
7001 a Tung, Nadine4 aut
7001 a Ainsworth, Peter J4 aut
7001 a Cummings, Shelly4 aut
7001 a Sun, Ping4 aut
7001 a Narod, Steven A4 aut
7001 a Olsson, Håkanu Lund University,Lunds universitet,Medicinsk onkologi,Sektion I,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Tumörmikromiljö,Institutionen för kliniska vetenskaper, Lund,Medical oncology,Section I,Department of Clinical Sciences, Lund,Faculty of Medicine,Tumor microenvironment,Department of Clinical Sciences, Lund4 aut0 (Swepub:lu)onk-hol
7102 a Medicinsk onkologib Sektion I4 org
7102 a Hereditary Breast Cancer Clinical Study Group
7730 t Cancer Causes and Controld : Springer Science and Business Media LLCg 19:10, s. 9-1111q 19:10<9-1111x 1573-7225x 0957-5243
8564 u http://dx.doi.org/10.1007/s10552-008-9175-0y FULLTEXT
8564 8u https://lup.lub.lu.se/record/7ba1fc85-c8fe-464a-928f-4a78532d2204
8564 8u https://doi.org/10.1007/s10552-008-9175-0

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