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Sökning: WFRF:(Andersen Anne Marie Nybo) > Fetal exposure to m...

LIBRIS Formathandbok  (Information om MARC21)
FältnamnIndikatorerMetadata
00004991naa a2200517 4500
001oai:lup.lub.lu.se:af25aef8-bb50-485e-82f8-3ee73a8fdfd3
003SwePub
008220704s2022 | |||||||||||000 ||eng|
0247 a https://lup.lub.lu.se/record/af25aef8-bb50-485e-82f8-3ee73a8fdfd32 URI
0247 a https://doi.org/10.1007/s10654-022-00869-22 DOI
040 a (SwePub)lu
041 a engb eng
042 9 SwePub
072 7a art2 swepub-publicationtype
072 7a ref2 swepub-contenttype
1001 a Hærvig, Katia Keglbergu Copenhagen University Hospital4 aut
2451 0a Fetal exposure to maternal cigarette smoking and male reproductive function in young adulthood
264 c 2022-04-27
264 1b Springer Science and Business Media LLC,c 2022
300 a 14 s.
520 a Maternal smoking during pregnancy constitutes a potential, major risk factor for adult male reproductive function. In the hitherto largest longitudinal cohort, we examined biomarkers of reproductive function according to maternal smoking during the first trimester and investigated whether associations were mitigated by smoking cessation prior to the fetal masculinization programming window. Associations between exposure to maternal smoking and semen characteristics, testicular volume and reproductive hormones were assessed among 984 young men from the Fetal Programming of Semen Quality (FEPOS) cohort. Maternal smoking was assessed through interview data and measured plasma cotinine levels during pregnancy. We applied negative binomial, logistic and linear regression models to estimate differences in outcomes according to levels of maternal smoking. Sons of light smokers (≤ 10 cigarettes/day) had a 19% (95% CI − 29%, − 6%) lower sperm concentration and a 24% (95% CI − 35%, − 11%) lower total sperm count than sons of non-smokers. These estimates were 38% (95% CI − 52%, − 22%) and 33% (95% CI − 51%, − 8%), respectively, for sons of heavy smokers (> 10 cigarettes/day). The latter group also had a 25% (95% CI 1%, 54%) higher follitropin level. Similarly, sons exposed to maternal cotinine levels of > 10 ng/mL had lower sperm concentration and total sperm count. Smoking cessation prior to gestational week seven was not associated with a higher reproductive capacity. We observed substantial and consistent exposure–response associations, providing strong support for the hypothesis that maternal smoking impairs male reproductive function. This association persisted regardless of smoking cessation in early pregnancy.
650 7a MEDICIN OCH HÄLSOVETENSKAPx Hälsovetenskapx Arbetsmedicin och miljömedicin0 (SwePub)303032 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Health Sciencesx Occupational Health and Environmental Health0 (SwePub)303032 hsv//eng
650 7a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Reproduktionsmedicin och gynekologi0 (SwePub)302202 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Obstetrics, Gynaecology and Reproductive Medicine0 (SwePub)302202 hsv//eng
653 a Fetal programming
653 a Male infertility
653 a Maternal smoking
653 a Prenatal exposure
653 a Reproductive hormones
653 a Semen quality
7001 a Petersen, Kajsa Ugelvigu Copenhagen University Hospital4 aut
7001 a Giwercman, Aleksanderu Lund University,Lunds universitet,Molekylärgenetisk reproduktionsmedicin, Malmö,Forskargrupper vid Lunds universitet,Reproduktionsmedicin, Malmö,Molecular genetic reproductive medicine, Malmö,Lund University Research Groups,Reproductive medicine, Malmö4 aut0 (Swepub:lu)kir-agi
7001 a Hougaard, Karin Sørigu University of Copenhagen,The National Research Centre for the Working Environment4 aut
7001 a Høyer, Birgit Bjerreu Copenhagen University Hospital4 aut
7001 a Lindh, Christianu Lund University,Lunds universitet,Tillämpad masspektrometri inom miljömedicin,Forskargrupper vid Lunds universitet,Applied Mass Spectrometry in Environmental Medicine,Lund University Research Groups4 aut0 (Swepub:lu)ymed-cli
7001 a Ramlau-Hansen, Cecilia Høstu Aarhus University4 aut
7001 a Nybo Andersen, Anne Marieu University of Copenhagen4 aut
7001 a Toft, Gunnaru Aarhus University Hospital4 aut
7001 a Bonde, Jens Peteru University of Copenhagen,Copenhagen University Hospital4 aut
7001 a Tøttenborg, Sandra Søgaardu Copenhagen University Hospital,University of Copenhagen4 aut
7102 a Copenhagen University Hospitalb Molekylärgenetisk reproduktionsmedicin, Malmö4 org
7730 t European Journal of Epidemiologyd : Springer Science and Business Media LLCg 37:5, s. 525-538q 37:5<525-538x 0393-2990x 1573-7284
8564 u http://dx.doi.org/10.1007/s10654-022-00869-2y FULLTEXT
8564 8u https://lup.lub.lu.se/record/af25aef8-bb50-485e-82f8-3ee73a8fdfd3
8564 8u https://doi.org/10.1007/s10654-022-00869-2

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