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LIBRIS Formathandbok  (Information om MARC21)
FältnamnIndikatorerMetadata
00006319naa a2200829 4500
001oai:lup.lub.lu.se:268b40ed-e218-4ede-9b5b-a62d9e8f2a20
003SwePub
008220208s2021 | |||||||||||000 ||eng|
0247 a https://lup.lub.lu.se/record/268b40ed-e218-4ede-9b5b-a62d9e8f2a202 URI
0247 a https://doi.org/10.1093/brain/awab2622 DOI
040 a (SwePub)lu
041 a engb eng
042 9 SwePub
072 7a art2 swepub-publicationtype
072 7a ref2 swepub-contenttype
1001 a Yushkevich, Paul A.u University of Pennsylvania4 aut
2451 0a Three-dimensional mapping of neurofibrillary tangle burden in the human medial temporal lobe
264 c 2021-07-14
264 1b Oxford University Press (OUP),c 2021
300 a 14 s.
520 a Tau protein neurofibrillary tangles are closely linked to neuronal/synaptic loss and cognitive decline in Alzheimer's disease and related dementias. Our knowledge of the pattern of neurofibrillary tangle progression in the human brain, critical to the development of imaging biomarkers and interpretation of in vivo imaging studies in Alzheimer's disease, is based on conventional two-dimensional histology studies that only sample the brain sparsely. To address this limitation, ex vivo MRI and dense serial histological imaging in 18 human medial temporal lobe specimens (age 75.3 ± 11.4 years, range 45 to 93) were used to construct three-dimensional quantitative maps of neurofibrillary tangle burden in the medial temporal lobe at individual and group levels. Group-level maps were obtained in the space of an in vivo brain template, and neurofibrillary tangles were measured in specific anatomical regions defined in this template. Three-dimensional maps of neurofibrillary tangle burden revealed significant variation along the anterior-posterior axis. While early neurofibrillary tangle pathology is thought to be confined to the transentorhinal region, we found similar levels of burden in this region and other medial temporal lobe subregions, including amygdala, temporopolar cortex, and subiculum/cornu ammonis 1 hippocampal subfields. Overall, the three-dimensional maps of neurofibrillary tangle burden presented here provide more complete information about the distribution of this neurodegenerative pathology in the region of the cortex where it first emerges in Alzheimer's disease, and may help inform the field about the patterns of pathology spread, as well as support development and validation of neuroimaging biomarkers.
650 7a MEDICIN OCH HÄLSOVETENSKAPx Medicinska och farmaceutiska grundvetenskaperx Neurovetenskaper0 (SwePub)301052 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Basic Medicinex Neurosciences0 (SwePub)301052 hsv//eng
653 a Alzheimer's disease
653 a medial temporal lobe
653 a neurodegeneration
653 a neurofibrillary tangles
7001 a Muñoz López, Mónicau University of Castilla La Mancha4 aut
7001 a Iñiguez De Onzoño Martin, María Mercedesu University of Castilla La Mancha4 aut
7001 a Ittyerah, Ranjitu University of Pennsylvania4 aut
7001 a Lim, Sydneyu University of Pennsylvania4 aut
7001 a Ravikumar, Sadhanau University of Pennsylvania4 aut
7001 a Bedard, Madigan L.u University of Pennsylvania4 aut
7001 a Pickup, Stephenu University of Pennsylvania4 aut
7001 a Liu, Weixiau University of Pennsylvania4 aut
7001 a Wang, Jiancongu University of Pennsylvania4 aut
7001 a Hung, Ling Yuu University of Pennsylvania4 aut
7001 a Lasserve, Jadeu University of Pennsylvania4 aut
7001 a Vergnet, Nicolasu University of Pennsylvania4 aut
7001 a Xie, Longu University of Pennsylvania4 aut
7001 a Dong, Mengjinu University of Pennsylvania4 aut
7001 a Cui, Salenau University of Pennsylvania4 aut
7001 a McCollum, Laurenu University of Pennsylvania4 aut
7001 a Robinson, John L.u University of Pennsylvania4 aut
7001 a Schuck, Theresau University of Pennsylvania4 aut
7001 a De Flores, Robinu Institut Gustave Roussy4 aut
7001 a Grossman, Murrayu University of Pennsylvania4 aut
7001 a Tisdall, M. Dylanu University of Pennsylvania4 aut
7001 a Prabhakaran, Karthiku University of Pennsylvania4 aut
7001 a Mizsei, Gaboru University of Pennsylvania4 aut
7001 a Das, Sandhitsu R.u University of Pennsylvania4 aut
7001 a Artacho-Pérula, Emiliou University of Castilla La Mancha4 aut
7001 a Del Mar Arroyo Jiménez, Marl'au University of Castilla La Mancha4 aut
7001 a Marcos Raba, Marl'a Pilaru University of Castilla La Mancha4 aut
7001 a Molina Romero, Francisco Javieru University of Castilla La Mancha4 aut
7001 a Cebada Sánchez, Sandrau University of Castilla La Mancha4 aut
7001 a Delgado González, José Carlosu University of Castilla La Mancha4 aut
7001 a De La Rosa-Prieto, Carlosu University of Castilla La Mancha4 aut
7001 a Córcoles Parada, Martau University of Castilla La Mancha4 aut
7001 a Lee, Edward B.u University of Pennsylvania4 aut
7001 a Trojanowski, John Q.u University of Pennsylvania4 aut
7001 a Ohm, Daniel T.u University of Pennsylvania4 aut
7001 a Wisse, Laura E.M.u Lund University,Lunds universitet,Diagnostisk radiologi, Lund,Sektion V,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Diagnostic Radiology, (Lund),Section V,Department of Clinical Sciences, Lund,Faculty of Medicine4 aut0 (Swepub:lu)la3343wi
7001 a Wolk, David A.u University of Pennsylvania4 aut
7001 a Irwin, David J.u University of Pennsylvania4 aut
7001 a Insausti, Ricardou University of Castilla La Mancha4 aut
7102 a University of Pennsylvaniab University of Castilla La Mancha4 org
7730 t Braind : Oxford University Press (OUP)g 144:9, s. 2784-2797q 144:9<2784-2797x 0006-8950x 1460-2156
8564 u http://dx.doi.org/10.1093/brain/awab262y FULLTEXT
8564 u https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8783607
8564 8u https://lup.lub.lu.se/record/268b40ed-e218-4ede-9b5b-a62d9e8f2a20
8564 8u https://doi.org/10.1093/brain/awab262

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