WFRF:(Bendall J)
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| Fältnamn | Indikatorer | Metadata |
|---|---|---|
| 000 | 03450naa a2200385 4500 | |
| 001 | oai:lup.lub.lu.se:08513c01-ae4e-4e12-9fba-0c6a1164e00e | |
| 003 | SwePub | |
| 008 | 160404s2011 | |||||||||||000 ||eng| | |
| 024 | 7 | a https://lup.lub.lu.se/record/19725482 URI |
| 024 | 7 | a https://doi.org/10.1111/j.1399-6576.2011.02436.x2 DOI |
| 040 | a (SwePub)lu | |
| 041 | a engb eng | |
| 042 | 9 SwePub | |
| 072 | 7 | a art2 swepub-publicationtype |
| 072 | 7 | a ref2 swepub-contenttype |
| 100 | 1 | a Chew, Michelleu Lund University,Lunds universitet,Anestesiologi och intensivvård,Forskargrupper vid Lunds universitet,Anaesthesiology and Intensive Care Medicine,Lund University Research Groups4 aut0 (Swepub:lu)anes-mch |
| 245 | 1 0 | a No beneficial effects of levosimendan in acute porcine endotoxaemia. |
| 264 | c 2011-05-16 | |
| 264 | 1 | b Wiley,c 2011 |
| 520 | a Background: Levosimendan has been proposed as an attractive alternative to adrenergic agents for the treatment of sepsis-induced heart failure and haemodynamic derangements. Its use in this setting is, however, still not well investigated. The aim of this study was to test the hypothesis that levosimendan is able to attenuate endotoxin-induced pulmonary hypertension and improve myocardial function in a porcine model. The secondary aims were to investigate its effect on renal and liver function, and the plasma cytokine response. Methods: Endotoxaemia was induced in 18 pigs, randomized to placebo and Levosimendan groups. All pigs were fluid resuscitated and Noradrenalin infusion was given according to a predefined protocol. Systemic haemodynamics and myocardial function were measured using pulmonary artery catheterization and transthoracic echocardiography. Renal and liver function tests and cytokine concentrations were measured in plasma. Results: Levosimendan did not attenuate endotoxin-induced pulmonary hypertension and did not improve myocardial function. There were no differences in renal or liver function. Increases in arterial lactate and decreases in base excess were observed in the Levosimendan group, as well as significant increases in plasma interleukin (IL)-6 and IL-8. Conclusions: Contrary to our hypothesis, levosimendan given in conjunction with a protocolized vasopressor and fluid resuscitation did not improve cardiac, renal or liver function in this model of acute porcine endotoxaemia. Hyperlactataemia, acidosis and increases in plasma pro-inflammatory cytokines were observed, the mechanisms and implications of which remain unclear. | |
| 650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Anestesi och intensivvård0 (SwePub)302012 hsv//swe |
| 650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Anesthesiology and Intensive Care0 (SwePub)302012 hsv//eng |
| 700 | 1 | a Hawthorne, W J4 aut |
| 700 | 1 | a Bendall, J4 aut |
| 700 | 1 | a Whereat, S4 aut |
| 700 | 1 | a Huang, S4 aut |
| 700 | 1 | a Ting, I4 aut |
| 700 | 1 | a Simond, D4 aut |
| 700 | 1 | a McLean, A4 aut |
| 710 | 2 | a Anestesiologi och intensivvårdb Forskargrupper vid Lunds universitet4 org |
| 773 | 0 | t Acta Anaesthesiologica Scandinavicad : Wileyg 55, s. 851-861q 55<851-861x 0001-5172 |
| 856 | 4 | u http://www.ncbi.nlm.nih.gov/pubmed/21574964?dopt=Abstracty FULLTEXT |
| 856 | 4 | u http://dx.doi.org/10.1111/j.1399-6576.2011.02436.xy FULLTEXT |
| 856 | 4 8 | u https://lup.lub.lu.se/record/1972548 |
| 856 | 4 8 | u https://doi.org/10.1111/j.1399-6576.2011.02436.x |
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