Sökning: WFRF:(Bergman Åke) > Hydroxyl metabolite...
Fältnamn | Indikatorer | Metadata |
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000 | 04346naa a2200541 4500 | |
001 | oai:DiVA.org:umu-109912 | |
003 | SwePub | |
008 | 151009s2015 | |||||||||||000 ||eng| | |
009 | oai:prod.swepub.kib.ki.se:131997811 | |
009 | oai:DiVA.org:su-121656 | |
024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-1099122 URI |
024 | 7 | a https://doi.org/10.1016/j.cbi.2015.07.0022 DOI |
024 | 7 | a http://kipublications.ki.se/Default.aspx?queryparsed=id:1319978112 URI |
024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-1216562 URI |
040 | a (SwePub)umud (SwePub)kid (SwePub)su | |
041 | a engb eng | |
042 | 9 SwePub | |
072 | 7 | a ref2 swepub-contenttype |
072 | 7 | a art2 swepub-publicationtype |
100 | 1 | a Al-Anati, Lauy4 aut |
245 | 1 0 | a Hydroxyl metabolite of PCB 180 induces DNA damage signaling and enhances the DNA damaging effect of benzo[a]pyrene |
264 | 1 | b Elsevier,c 2015 |
338 | a print2 rdacarrier | |
520 | a Non-dioxin-like (NDL) polychlorinated biphenyls (PCBs) and their hydroxyl metabolites (OH-PCBs) are ubiquitous environmental contaminants in human tissues and blood. The toxicological impact of these metabolites is poorly understood. In this study rats were exposed to ultrapure PCB180 (10-1000 mg/kg bw) for 28 days and induction of genotoxic stress in liver was investigated. DNA damage signaling proteins (pChk1Ser317 and gamma H2AXSer319) were increased dose dependently in female rats. This increase was paralleled by increasing levels of the metabolite 3'-OH-PCB180. pChk1 was the most sensitive marker. In in vitro studies HepG2 cells were exposed to 1 mu M of PCB180 and 3'-OH-PCB180 or the positive control benzo[a]pyrene (BaP, 5 mu M). 3'-OH-PCB180, but not PCB180, induced CYP1A1 mRNA and gamma H2AX. CYP1A1 mRNA induction was seen at 1 h, and gamma H2AX at 3 h. The anti-oxidant N-Acetyl-L-Cysteine (NAC) completely prevented, and 17 beta-estradiol amplified the gamma H2AX induction by 3'-OH-PCB180. As 3'-OH-PCB180 induced CYP1A1, a major BaP-metabolizing and activating enzyme, interactions between 3'-OH-PCB180 and BaP was also studied. The metabolite amplified the DNA damage signaling response to BaP. In conclusion, metabolism of PCB180 to its hydroxyl metabolite and the subsequent induction of CYP1A1 seem important for DNA damage induced by PCB180 in vivo. Amplification of the response with estradiol may explain why DNA damage was only seen in female rats. | |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Medicinsk bioteknologix Medicinsk bioteknologi0 (SwePub)304012 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Medical Biotechnologyx Medical Biotechnology0 (SwePub)304012 hsv//eng |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Medicinska och farmaceutiska grundvetenskaperx Farmakologi och toxikologi0 (SwePub)301022 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Basic Medicinex Pharmacology and Toxicology0 (SwePub)301022 hsv//eng |
650 | 7 | a NATURVETENSKAPx Biologi0 (SwePub)1062 hsv//swe |
650 | 7 | a NATURAL SCIENCESx Biological Sciences0 (SwePub)1062 hsv//eng |
653 | a NDL-PCBs | |
653 | a Hydroxy-PCBs | |
653 | a Benzo(a)pyrene | |
653 | a DNA damage | |
653 | a CYP1A1mRNA induction | |
653 | a Oxidative stress | |
700 | 1 | a Viluksela, Matti4 aut |
700 | 1 | a Strid, Annau Stockholms universitet,Institutionen för miljövetenskap och analytisk kemi4 aut0 (Swepub:su)astri |
700 | 1 | a Bergman, Åkeu Stockholms universitet,Karolinska Institutet,Institutionen för miljövetenskap och analytisk kemi,Swedish Toxicology Sciences Research Center (Swetox), Sweden4 aut0 (Swepub:su)alb |
700 | 1 | a Andersson, Patrik Lu Umeå universitet,Kemiska institutionen4 aut0 (Swepub:umu)paan0001 |
700 | 1 | a Stenius, Ullau Karolinska Institutet4 aut |
700 | 1 | a Högberg, Johanu Karolinska Institutet4 aut |
710 | 2 | a Stockholms universitetb Institutionen för miljövetenskap och analytisk kemi4 org |
773 | 0 | t Chemico-Biological Interactionsd : Elsevierg 239, s. 164-173q 239<164-173x 0009-2797x 1872-7786 |
856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-109912 |
856 | 4 8 | u https://doi.org/10.1016/j.cbi.2015.07.002 |
856 | 4 8 | u http://kipublications.ki.se/Default.aspx?queryparsed=id:131997811 |
856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-121656 |
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