Prevalence of herpes simplex virus antibodies in childhood and adolescence: a cross-sectional study.

• The changing spectrum of herpes simplex virus type 1 (HSV-1) and herpes simplex virus type 2 (HSV-2) infections makes it important to define the seroepidemiology of HSV. The object of this study was to determine the prevalence of HSV-1 and HSV-2 immunoglobulin G antibodies in a young Swedish population by investigating 2106 serum samples from people aged 0-19 y. Sera were tested in HSV type-specific enzyme-linked immunosorbent assays using glycoprotein G-1 (gG-1) and glycoprotein G-2 (gG-2) as antigens. The overall seroprevalence was 31% (95% CI 29-33) for HSV-1 and 0.5% (95% CI 0.2-0.9) for HSV-2. The HSV-1 seroprevalence was higher with increasing age, and significantly higher in the age cohort 15-19 y compared with 1-4-y-olds (37% vs 24%). The HSV-1 infection seemed to be acquired early in life. In the age cohort 1-2 y, the prevalence was over 20%, presumably reflecting an established viral infection. In adolescence the HSV-1 seroprevalence may reflect both oral and sexual transmission. The seroprevalence in the oldest age cohort did not differ significantly from that seen in a Swedish study in which sera were sampled from young girls in the 1970s.

Ämnesord

MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Dermatologi och venereologi (hsv//swe)

MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Dermatology and Venereal Diseases (hsv//eng)

Nyckelord

Adolescent

Adult

Age Distribution

Antibodies

Viral

analysis

Child

Child

Preschool

Cohort Studies

Confidence Intervals

Enzyme-Linked Immunosorbent Assay

Female

Follow-Up Studies

Herpes Simplex

epidemiology

immunology

Herpesvirus 1

Human

immunology

Herpesvirus 2

Human

immunology

Humans

Infant

Male

Prevalence

Probability

Reproducibility of Results

Risk Assessment

Seroepidemiologic Studies

Serologic Tests

Sex Distribution

Sweden

epidemiology

Publikations- och innehållstyp

ref (ämneskategori)

art (ämneskategori)