Metabolic syndrome and endometrial carcinoma

The authors examined the association between the metabolic syndrome and risk of incident endometrial and fatal uterine corpus cancer within a large prospective cohort study. Approximately 290,000 women from Austria, Norway, and Sweden were enrolled during 1974-2005, with measurements of height, weight, systolic and diastolic blood pressure, and circulating levels of glucose, total cholesterol, and triglycerides. Relative risks were estimated using Cox proportional hazards regression. The metabolic syndrome was assessed as a composite z score, as the standardized sum of z scores for body mass index, blood pressure, glucose, cholesterol, and triglycerides. A total of 917 endometrial carcinomas and 129 fatal cancers were identified. Increased risks of incident endometrial carcinoma and fatal uterine corpus cancer were seen for the metabolic syndrome factors combined, as well as for individual factors (except for cholesterol). The relative risk of endometrial carcinoma for the metabolic syndrome was 1.37 (95% confidence interval: 1.28, 1.46) per 1-unit increment of z score. The positive associations between metabolic syndrome factors (both individually and combined) and endometrial carcinoma were confined to the heaviest women. The association between the metabolic syndrome and endometrial carcinoma risk seems to go beyond the risk conferred by obesity alone, particularly in women with a high body mass index.

MEDICIN OCH HÄLSOVETENSKAP Hälsovetenskap Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi hsv//swe
MEDICAL AND HEALTH SCIENCES Health Sciences Public Health, Global Health, Social Medicine and Epidemiology hsv//eng
adult
blood glucose/analysis
breast neoplasms/epidemiology/etiology/prevention & control
colorectal neoplasms/epidemiology/etiology/prevention & control
developed countries
emigrants and immigrants
female
humans
incidence
insulin resistance
life style
male
metabolic syndrome X/complications
neoplasms/epidemiology/etiology/*prevention & control
obesity/complications
overweight/complications
prostatic neoplasms/epidemiology/etiology/prevention & control
risk factors
Sweden/epidemiology
world health
cohort studies
endometrial neoplasm
MEDICINE
MEDICIN
cohort studies
endometrial neoplasms
metabolic syndrome X

Stocks, TanjaUmeå University,Umeå universitet,Urologi och andrologi(Swepub:lu)med-tss (författare)
Lukanova, Annekatrin (författare)
Tretli, Steinar (författare)
Selmer, Randi (författare)
Manjer, JonasLund University,Lunds universitet,Kirurgi,Forskargrupper vid Lunds universitet,Surgery,Lund University Research Groups(Swepub:lu)smi-jma (författare)
Rapp, Kilian (författare)
Ulmer, Hanno (författare)
Almquist, MartinLund University,Lunds universitet,Kirurgi,Forskargrupper vid Lunds universitet,Surgery,Lund University Research Groups(Swepub:lu)kir-mal (författare)
Concin, Hans (författare)
Hallmans, GöranUmeå universitet,Institutionen för folkhälsa och klinisk medicin,Näringsforskning(Swepub:umu)goha0001 (författare)
Jonsson, HåkanUmeå universitet,Onkologi(Swepub:umu)hojo0001 (författare)
Stattin, PärUmeå universitet,Urologi och andrologi(Swepub:umu)past0003 (författare)
Engeland, Anders (författare)
Umeå universitetUrologi och andrologi (creator_code:org_t)

Ingår i:American Journal of Epidemiology: Oxford University Press (OUP)171:8, s. 892-9020002-92621476-6256

Av författaren/redakt...: Bjørge, Tone; Stocks, Tanja; Lukanova, Anneka ...; Tretli, Steinar; Selmer, Randi; Manjer, Jonas; visa fler...; Rapp, Kilian; Ulmer, Hanno; Almquist, Martin; Concin, Hans; Hallmans, Göran; Jonsson, Håkan; Stattin, Pär; Engeland, Anders; visa färre...

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