WFRF:(Bjornsson P.)
Sökning: WFRF:(Bjornsson P.) > Genome-wide meta-an...
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| Fältnamn | Indikatorer | Metadata |
|---|---|---|
| 000 | 04831naa a2200973 4500 | |
| 001 | oai:DiVA.org:hj-43026 | |
| 003 | SwePub | |
| 008 | 190218s2019 | |||||||||||000 ||eng| | |
| 009 | oai:prod.swepub.kib.ki.se:140435539 | |
| 024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:hj:diva-430262 URI |
| 024 | 7 | a https://doi.org/10.1038/s41588-018-0311-92 DOI |
| 024 | 7 | a http://kipublications.ki.se/Default.aspx?queryparsed=id:1404355392 URI |
| 040 | a (SwePub)hjd (SwePub)ki | |
| 041 | a engb eng | |
| 042 | 9 SwePub | |
| 072 | 7 | a ref2 swepub-contenttype |
| 072 | 7 | a art2 swepub-publicationtype |
| 100 | 1 | a Jansen, I. E.4 aut |
| 245 | 1 0 | a Genome-wide meta-analysis identifies new loci and functional pathways influencing Alzheimer’s disease risk |
| 264 | c 2019-01-07 | |
| 264 | 1 | b Nature Publishing Group,c 2019 |
| 338 | a print2 rdacarrier | |
| 520 | a Alzheimer’s disease (AD) is highly heritable and recent studies have identified over 20 disease-associated genomic loci. Yet these only explain a small proportion of the genetic variance, indicating that undiscovered loci remain. Here, we performed a large genome-wide association study of clinically diagnosed AD and AD-by-proxy (71,880 cases, 383,378 controls). AD-by-proxy, based on parental diagnoses, showed strong genetic correlation with AD (rg = 0.81). Meta-analysis identified 29 risk loci, implicating 215 potential causative genes. Associated genes are strongly expressed in immune-related tissues and cell types (spleen, liver, and microglia). Gene-set analyses indicate biological mechanisms involved in lipid-related processes and degradation of amyloid precursor proteins. We show strong genetic correlations with multiple health-related outcomes, and Mendelian randomization results suggest a protective effect of cognitive ability on AD risk. These results are a step forward in identifying the genetic factors that contribute to AD risk and add novel insights into the neurobiology of AD. | |
| 650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Neurologi0 (SwePub)302072 hsv//swe |
| 650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Neurology0 (SwePub)302072 hsv//eng |
| 700 | 1 | a Savage, J. E.4 aut |
| 700 | 1 | a Watanabe, K.4 aut |
| 700 | 1 | a Bryois, J.u Karolinska Institutet4 aut |
| 700 | 1 | a Williams, D. M.u Karolinska Institutet4 aut |
| 700 | 1 | a Steinberg, S.u Karolinska Institutet4 aut |
| 700 | 1 | a Sealock, J.4 aut |
| 700 | 1 | a Karlsson, Ida K.u Jönköping University,HHJ, Institutet för gerontologi,HHJ. ARN-J (Aging Research Network - Jönköping),Karolinska Institutet, Stockholm, Sweden4 aut0 (Swepub:hj)karida |
| 700 | 1 | a Hägg, S.4 aut |
| 700 | 1 | a Athanasiu, L.4 aut |
| 700 | 1 | a Voyle, N.4 aut |
| 700 | 1 | a Proitsi, P.u Karolinska Institutet4 aut |
| 700 | 1 | a Witoelar, A.4 aut |
| 700 | 1 | a Stringer, S.4 aut |
| 700 | 1 | a Aarsland, D.u Karolinska Institutet4 aut |
| 700 | 1 | a Almdahl, I. S.4 aut |
| 700 | 1 | a Andersen, F.4 aut |
| 700 | 1 | a Bergh, S.4 aut |
| 700 | 1 | a Bettella, F.4 aut |
| 700 | 1 | a Bjornsson, S.4 aut |
| 700 | 1 | a Brækhus, A.4 aut |
| 700 | 1 | a Bråthen, G.4 aut |
| 700 | 1 | a de Leeuw, C.4 aut |
| 700 | 1 | a Desikan, R. S.4 aut |
| 700 | 1 | a Djurovic, S.4 aut |
| 700 | 1 | a Dumitrescu, L.4 aut |
| 700 | 1 | a Fladby, T.4 aut |
| 700 | 1 | a Hohman, T. J.4 aut |
| 700 | 1 | a Jonsson, P. V.4 aut |
| 700 | 1 | a Kiddle, S. J.4 aut |
| 700 | 1 | a Rongve, A.4 aut |
| 700 | 1 | a Saltvedt, I.4 aut |
| 700 | 1 | a Sando, S. B.4 aut |
| 700 | 1 | a Selbæk, G.4 aut |
| 700 | 1 | a Shoai, M.4 aut |
| 700 | 1 | a Skene, N. G.4 aut |
| 700 | 1 | a Snaedal, J.4 aut |
| 700 | 1 | a Stordal, E.4 aut |
| 700 | 1 | a Ulstein, I. D.4 aut |
| 700 | 1 | a Wang, Y.4 aut |
| 700 | 1 | a White, L. R.4 aut |
| 700 | 1 | a Hardy, J.4 aut |
| 700 | 1 | a Hjerling-Leffler, J.u Karolinska Institutet4 aut |
| 700 | 1 | a Sullivan, P. F.4 aut |
| 700 | 1 | a van der Flier, W. M.4 aut |
| 700 | 1 | a Dobson, R.4 aut |
| 700 | 1 | a Davis, L. K.4 aut |
| 700 | 1 | a Stefansson, H.4 aut |
| 700 | 1 | a Stefansson, K.4 aut |
| 700 | 1 | a Pedersen, N. L.u Karolinska Institutet4 aut |
| 700 | 1 | a Ripke, S.4 aut |
| 700 | 1 | a Andreassen, O. A.4 aut |
| 700 | 1 | a Posthuma, D.4 aut |
| 710 | 2 | a Karolinska Institutetb HHJ, Institutet för gerontologi4 org |
| 773 | 0 | t Nature Geneticsd : Nature Publishing Groupg 51:3, s. 404-413q 51:3<404-413x 1061-4036x 1546-1718 |
| 856 | 4 | u https://doi.org/10.1038/s41588-019-0573-xy Author Correction |
| 856 | 4 | u https://europepmc.org/articles/pmc6836675?pdf=render |
| 856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:hj:diva-43026 |
| 856 | 4 8 | u https://doi.org/10.1038/s41588-018-0311-9 |
| 856 | 4 8 | u http://kipublications.ki.se/Default.aspx?queryparsed=id:140435539 |
Hitta mer i SwePub
- Av författaren/redakt...
- Jansen, I. E.
- Savage, J. E.
- Watanabe, K.
- Bryois, J.
- Williams, D. M.
- Steinberg, S.
- visa fler...
- Sealock, J.
- Karlsson, Ida K.
- Hägg, S.
- Athanasiu, L.
- Voyle, N.
- Proitsi, P.
- Witoelar, A.
- Stringer, S.
- Aarsland, D.
- Almdahl, I. S.
- Andersen, F.
- Bergh, S.
- Bettella, F.
- Bjornsson, S.
- Brækhus, A.
- Bråthen, G.
- de Leeuw, C.
- Desikan, R. S.
- Djurovic, S.
- Dumitrescu, L.
- Fladby, T.
- Hohman, T. J.
- Jonsson, P. V.
- Kiddle, S. J.
- Rongve, A.
- Saltvedt, I.
- Sando, S. B.
- Selbæk, G.
- Shoai, M.
- Skene, N. G.
- Snaedal, J.
- Stordal, E.
- Ulstein, I. D.
- Wang, Y.
- White, L. R.
- Hardy, J.
- Hjerling-Leffler ...
- Sullivan, P. F.
- van der Flier, W ...
- Dobson, R.
- Davis, L. K.
- Stefansson, H.
- Stefansson, K.
- Pedersen, N. L.
- Ripke, S.
- Andreassen, O. A ...
- Posthuma, D.
- visa färre...
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- Karolinska Institutet
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