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Fältnamn	Indikatorer	Metadata
000		07609naa a2201369 4500
001		oai:lup.lub.lu.se:17a9f062-dc3e-4135-95b2-d6f60c1d0114
003		SwePub
008		160401s2012 \| \|\|\|\|\|\|\|\|\|\|\|000 \|\|eng\|
009		oai:prod.swepub.kib.ki.se:125097305
024	7	a https://lup.lub.lu.se/record/30558232 URI
024	7	a https://doi.org/10.1016/j.jacc.2012.01.0782 DOI
024	7	a http://kipublications.ki.se/Default.aspx?queryparsed=id:1250973052 URI
040		a (SwePub)lud (SwePub)ki
041		a engb eng
042		9 SwePub
072	7	a art2 swepub-publicationtype
072	7	a ref2 swepub-contenttype
100	1	a Helgadottir, Anna4 aut
245	1 0	a Apolipoprotein(a) Genetic Sequence Variants Associated With Systemic Atherosclerosis and Coronary Atherosclerotic Burden But Not With Venous Thromboembolism
264	1	b Elsevier BV,c 2012
520		a Objectives The purpose of this study is investigate the effects of variants in the apolipoprotein(a) gene (LPA) on vascular diseases with different atherosclerotic and thrombotic components. Background It is unclear whether the LPA variants rs10455872 and rs3798220, which correlate with lipoprotein(a) levels and coronary artery disease (CAD), confer susceptibility predominantly via atherosclerosis or thrombosis. Methods The 2 LPA variants were combined and examined as LPA scores for the association with ischemic stroke (and TOAST [Trial of Org 10172 in Acute Stroke Treatment] subtypes) (effective sample size [n(e)] = 9,396); peripheral arterial disease (n(e) = 5,215); abdominal aortic aneurysm (ne = 4,572); venous thromboembolism (ne = 4,607); intracranial aneurysm (ne = 1,328); CAD (n(e) = 12,716), carotid intima-media thickness (n = 3,714), and angiographic CAD severity (n = 5,588). Results LPA score was associated with ischemic stroke subtype large artery atherosclerosis (odds ratio [OR]: 1.27; p = 6.7 X 10(-4)), peripheral artery disease (OR: 1.47; p = 2.9 x 10(-14)), and abdominal aortic aneurysm (OR: 1.23; p = 6.0 x 10(-5)), but not with the ischemic stroke subtypes cardioembolism (OR: 1.03; p = 0.69) or small vessel disease (OR: 1.06; p = 0.52). Although the LPA variants were not associated with carotid intima-media thickness, they were associated with the number of obstructed coronary vessels (p = 4.8 x 10(-12)). Furthermore, CAD cases carrying LPA risk variants had increased susceptibility to atherosclerotic manifestations outside of the coronary tree (OR: 1.26; p = 0.0010) and had earlier onset of CAD (-1.58 years/allele; p = 8.2 x 10(-8)) than CAD cases not carrying the risk variants. There was no association of LPA score with venous thromboembolism (OR: 0.97; p = 0.63) or intracranial aneurysm (OR: 0.85; p = 0.15). Conclusions LPA sequence variants were associated with atherosclerotic burden, but not with primarily thrombotic phenotypes. (J Am Coll Cardiol 2012; 60: 722-9) (C) 2012 by the American College of Cardiology Foundation
650	7	a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Kardiologi0 (SwePub)302062 hsv//swe
650	7	a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Cardiac and Cardiovascular Systems0 (SwePub)302062 hsv//eng
653		a association
653		a atherosclerosis
653		a genetic
653		a lipoprotein(a)
653		a thrombosis
700	1	a Gretarsdottir, Solveig4 aut
700	1	a Thorleifsson, Gudmar4 aut
700	1	a Holm, Hilma4 aut
700	1	a Patel, Riyaz S.4 aut
700	1	a Gudnason, Thorarinn4 aut
700	1	a Jones, Gregory T.4 aut
700	1	a van Rij, Andre M.4 aut
700	1	a Eapen, Danny J.4 aut
700	1	a Baas, Annette F.4 aut
700	1	a Tregouet, David-Alexandre4 aut
700	1	a Morange, Pierre-Emmanuel4 aut
700	1	a Emmerich, Joseph4 aut
700	1	a Lindblad, Bengtu Lund University,Lunds universitet,Vaskulära sjukdomar - kliniska studier,Forskargrupper vid Lunds universitet,Vascular Diseases - Clinical Research,Lund University Research Groups4 aut0 (Swepub:lu)kir-bli
700	1	a Gottsäter, Andersu Lund University,Lunds universitet,Vaskulära sjukdomar - kliniska studier,Forskargrupper vid Lunds universitet,Vascular Diseases - Clinical Research,Lund University Research Groups4 aut0 (Swepub:lu)medf-ago
700	1	a Kiemeny, Lambertus A.4 aut
700	1	a Lindholt, Jes S.4 aut
700	1	a Sakalihasan, Natzi4 aut
700	1	a Ferrell, Robert E.4 aut
700	1	a Carey, David J.4 aut
700	1	a Elmore, James R.4 aut
700	1	a Tsao, Philip S.4 aut
700	1	a Grarup, Niels4 aut
700	1	a Jorgensen, Torben4 aut
700	1	a Witte, Daniel R.4 aut
700	1	a Hansen, Torben4 aut
700	1	a Pedersen, Oluf4 aut
700	1	a Pola, Roberto4 aut
700	1	a Gaetani, Eleonora4 aut
700	1	a Magnadottir, Hulda B.4 aut
700	1	a Wijmenga, Cisca4 aut
700	1	a Tromp, Gerard4 aut
700	1	a Ronkainen, Antti4 aut
700	1	a Ruigrok, Ynte M.4 aut
700	1	a Blankensteijn, Jan D.4 aut
700	1	a Mueller, Thomas4 aut
700	1	a Wells, Philip S.4 aut
700	1	a Corral, Javier4 aut
700	1	a Manuel Soria, Jose4 aut
700	1	a Carlos Souto, Juan4 aut
700	1	a Peden, John F.4 aut
700	1	a Jalilzadeh, Shapour4 aut
700	1	a Mayosi, Bongani M.4 aut
700	1	a Keavney, Bernard4 aut
700	1	a Strawbridge, Rona J.u Karolinska Institutet4 aut
700	1	a Sabater-Lleal, Mariau Karolinska Institutet4 aut
700	1	a Gertow, Karlu Karolinska Institutet4 aut
700	1	a Baldassarre, Damiano4 aut
700	1	a Nyyssonen, Kristiina4 aut
700	1	a Rauramaa, Rainer4 aut
700	1	a Smit, Andries J.4 aut
700	1	a Mannarino, Elmo4 aut
700	1	a Giral, Philippe4 aut
700	1	a Tremoli, Elena4 aut
700	1	a de Faire, Ulfu Karolinska Institutet4 aut
700	1	a Humphries, Steve E.4 aut
700	1	a Hamsten, Andersu Karolinska Institutet4 aut
700	1	a Haraldsdottir, Vilhelmina4 aut
700	1	a Olafsson, Isleifur4 aut
700	1	a Magnusson, Magnus K.u Karolinska Institutet4 aut
700	1	a Samani, Nilesh J.4 aut
700	1	a Levey, Allan I.4 aut
700	1	a Markus, Hugh S.4 aut
700	1	a Kostulas, Konstantinos4 aut
700	1	a Dichgans, Martin4 aut
700	1	a Berger, Klaus4 aut
700	1	a Kuhlenbaeumer, Gregor4 aut
700	1	a Ringelstein, E. Bernd4 aut
700	1	a Stoll, Monika4 aut
700	1	a Seedorf, Udo4 aut
700	1	a Rothwell, Peter M.4 aut
700	1	a Powell, Janet T.4 aut
700	1	a Kuivaniemi, Helena4 aut
700	1	a Onundarson, Pall T.4 aut
700	1	a Valdimarsson, Einar4 aut
700	1	a Matthiasson, Stefan E.4 aut
700	1	a Gudbjartsson, Daniel F.4 aut
700	1	a Thorgeirsson, Guomundur4 aut
700	1	a Quyyumi, Arshed A.4 aut
700	1	a Watkins, Hugh4 aut
700	1	a Farrall, Martin4 aut
700	1	a Thorsteinsdottir, Unnur4 aut
700	1	a Stefansson, Kari4 aut
710	2	a Vaskulära sjukdomar - kliniska studierb Forskargrupper vid Lunds universitet4 org
773	0	t Journal of the American College of Cardiologyd : Elsevier BVg 60:8, s. 722-729q 60:8<722-729x 0735-1097x 1558-3597
856	4	u http://dx.doi.org/10.1016/j.jacc.2012.01.078y FULLTEXT
856	4	u https://doi.org/10.1016/j.jacc.2012.01.078
856	4 8	u https://lup.lub.lu.se/record/3055823
856	4 8	u https://doi.org/10.1016/j.jacc.2012.01.078
856	4 8	u http://kipublications.ki.se/Default.aspx?queryparsed=id:125097305

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Av författaren/redakt...: Helgadottir, Ann ...; Gretarsdottir, S ...; Thorleifsson, Gu ...; Holm, Hilma; Patel, Riyaz S.; Gudnason, Thorar ...; visa fler...; Jones, Gregory T ...; van Rij, Andre M ...; Eapen, Danny J.; Baas, Annette F.; Tregouet, David- ...; Morange, Pierre- ...; Emmerich, Joseph; Lindblad, Bengt; Gottsäter, Ander ...; Kiemeny, Lambert ...; Lindholt, Jes S.; Sakalihasan, Nat ...; Ferrell, Robert ...; Carey, David J.; Elmore, James R.; Tsao, Philip S.; Grarup, Niels; Jorgensen, Torbe ...; Witte, Daniel R.; Hansen, Torben; Pedersen, Oluf; Pola, Roberto; Gaetani, Eleonor ...; Magnadottir, Hul ...; Wijmenga, Cisca; Tromp, Gerard; Ronkainen, Antti; Ruigrok, Ynte M.; Blankensteijn, J ...; Mueller, Thomas; Wells, Philip S.; Corral, Javier; Manuel Soria, Jo ...; Carlos Souto, Ju ...; Peden, John F.; Jalilzadeh, Shap ...; Mayosi, Bongani ...; Keavney, Bernard; Strawbridge, Ron ...; Sabater-Lleal, M ...; Gertow, Karl; Baldassarre, Dam ...; Nyyssonen, Krist ...; Rauramaa, Rainer; Smit, Andries J.; Mannarino, Elmo; Giral, Philippe; Tremoli, Elena; de Faire, Ulf; Humphries, Steve ...; Hamsten, Anders; Haraldsdottir, V ...; Olafsson, Isleif ...; Magnusson, Magnu ...; Samani, Nilesh J ...; Levey, Allan I.; Markus, Hugh S.; Kostulas, Konsta ...; Dichgans, Martin; Berger, Klaus; Kuhlenbaeumer, G ...; Ringelstein, E. ...; Stoll, Monika; Seedorf, Udo; Rothwell, Peter ...; Powell, Janet T.; Kuivaniemi, Hele ...; Onundarson, Pall ...; Valdimarsson, Ei ...; Matthiasson, Ste ...; Gudbjartsson, Da ...; Thorgeirsson, Gu ...; Quyyumi, Arshed ...; Watkins, Hugh; Farrall, Martin; Thorsteinsdottir ...; Stefansson, Kari; visa färre...

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