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Outcome after surge...
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Arnesen, ThomasHaukeland Hospital, Norway
(author)
Outcome after surgery for primary hyperaldosteronism may depend on KCNJ5 tumor mutation status: a population-based study from Western Norway
- Article/chapterEnglish2013
Publisher, publication year, extent ...
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2013-06-19
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Springer Verlag (Germany),2013
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printrdacarrier
Numbers
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LIBRIS-ID:oai:DiVA.org:liu-96978
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https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-96978URI
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https://doi.org/10.1007/s00423-013-1093-2DOI
Supplementary language notes
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Language:English
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Summary in:English
Part of subdatabase
Classification
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Subject category:ref swepub-contenttype
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Subject category:art swepub-publicationtype
Notes
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Funding Agencies|Western Norway Regional Health Authority||
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Primary aldosteronism (PA) is a frequent cause (about 10 %) of hypertension. Some cases of PA were recently found to be caused by mutations in the potassium channel KCNJ5. Our objective was to determine the mutation status of KCNJ5 and seven additional candidate genes for tumorigenesis: YY1, FZD4, ARHGAP9, ZFP37, KDM5C, LRP1B, and PDE9A and, furthermore, the surgical outcome of PA patients who underwent surgery in Western Norway. less thanbrgreater than less thanbrgreater thanTwenty-eight consecutive patients with aldosterone-producing adrenal tumors (20 patients with single adenoma, 8 patients with unilateral multiple adenomas or hyperplasia) who underwent surgery were included in this study. All patients were operated on by uncomplicated laparoscopic total adrenalectomy. Genomic DNA was isolated from tumor and non-tumor adrenocortical tissue, and DNA sequencing revealed the mutation status. less thanbrgreater than less thanbrgreater thanTen out of 28 (36 %) patients with PA displayed tumor mutations in KCNJ5 (p. G151R and L168R) while none were found in the corresponding non-tumor samples. No mutations were found in the other seven candidate genes screened. The presence of KCNJ5 mutations was associated with lower blood pressure and a higher chance for cure by surgery when compared to patients harboring the KCNJ5 wild type. less thanbrgreater than less thanbrgreater thanKCNJ5 mutations are associated with a better surgical outcome. Preoperative identification of the mutation status might have impact on surgical strategy (total vs. subtotal adrenalectomy).
Subject headings and genre
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Primary aldosteronism
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Aldosterone-producing tumors
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Conns syndrome
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KCNJ5
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Somatic mutations
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Western Norway
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MEDICINE
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MEDICIN
Added entries (persons, corporate bodies, meetings, titles ...)
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Glomnes, NinaUniversity of Bergen, Norway
(author)
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Stromsoy, SiriUniversity of Bergen, Norway
(author)
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Knappskog, StianUniversity of Bergen, Norway
(author)
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Heie, AnetteHaukeland Hospital, Norway
(author)
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Akslen, Lars A.University of Bergen, Norway
(author)
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Grytaas, MarianneHaukeland Hospital, Norway
(author)
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Varhaug, Jan ErikHaukeland Hospital, Norway
(author)
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Gimm, OliverÖstergötlands Läns Landsting,Linköpings universitet,Avdelningen för kliniska vetenskaper,Hälsouniversitetet,Kirurgiska kliniken US(Swepub:liu)oligi51
(author)
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Brauckhoff, MichaelHaukeland Hospital, Norway
(author)
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Haukeland Hospital, NorwayUniversity of Bergen, Norway
(creator_code:org_t)
Related titles
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In:Langenbeck's archives of surgery (Print): Springer Verlag (Germany)398:6, s. 869-8741435-24431435-2451
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Arnesen, Thomas
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Glomnes, Nina
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Stromsoy, Siri
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Knappskog, Stian
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Heie, Anette
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Akslen, Lars A.
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Grytaas, Mariann ...
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Varhaug, Jan Eri ...
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Gimm, Oliver
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Brauckhoff, Mich ...
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Linköping University