WFRF:(Brodtmann A.)
Sökning: WFRF:(Brodtmann A.) > Plasma neurofilamen...
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| Fältnamn | Indikatorer | Metadata |
|---|---|---|
| 000 | 07615naa a2200829 4500 | |
| 001 | oai:gup.ub.gu.se/328478 | |
| 003 | SwePub | |
| 008 | 240528s2023 | |||||||||||000 ||eng| | |
| 009 | oai:lup.lub.lu.se:414814e7-8b27-466b-8ad0-6ad9f8eaedcd | |
| 024 | 7 | a https://gup.ub.gu.se/publication/3284782 URI |
| 024 | 7 | a https://doi.org/10.1177/000486742311873122 DOI |
| 024 | 7 | a https://lup.lub.lu.se/record/414814e7-8b27-466b-8ad0-6ad9f8eaedcd2 URI |
| 040 | a (SwePub)gud (SwePub)lu | |
| 041 | a eng | |
| 042 | 9 SwePub | |
| 072 | 7 | a ref2 swepub-contenttype |
| 072 | 7 | a art2 swepub-publicationtype |
| 100 | 1 | a Eratne, D.u University of Melbourne,Royal Melbourne Hospital4 aut |
| 245 | 1 0 | a Plasma neurofilament light in behavioural variant frontotemporal dementia compared to mood and psychotic disorders |
| 264 | 1 | c 2023 |
| 520 | a Objective: Blood biomarkers of neuronal injury such as neurofilament light (NfL) show promise to improve diagnosis of neurodegenerative disorders and distinguish neurodegenerative from primary psychiatric disorders (PPD). This study investigated the diagnostic utility of plasma NfL to differentiate behavioural variant frontotemporal dementia (bvFTD, a neurodegenerative disorder commonly misdiagnosed initially as PPD), from PPD, and performance of large normative/reference data sets and models. Methods: Plasma NfL was analysed in major depressive disorder (MDD, n = 42), bipolar affective disorder (BPAD, n = 121), treatment-resistant schizophrenia (TRS, n = 82), bvFTD (n = 22), and compared to the reference cohort (Control Group 2, n = 1926, using GAMLSS modelling), and age-matched controls (Control Group 1, n = 96, using general linear models). Results: Large differences were seen between bvFTD (mean NfL 34.9 pg/mL) and all PPDs and controls (all < 11 pg/mL). NfL distinguished bvFTD from PPD with high accuracy, sensitivity (86%), and specificity (88%). GAMLSS models using reference Control Group 2 facilitated precision interpretation of individual levels, while performing equally to or outperforming models using local controls. Slightly higher NfL levels were found in BPAD, compared to controls and TRS. Conclusions: This study adds further evidence on the diagnostic utility of NfL to distinguish bvFTD from PPD of high clinical relevance to a bvFTD differential diagnosis, and includes the largest cohort of BPAD to date. Using large reference cohorts, GAMLSS modelling and the interactive Internet-based application we developed, may have important implications for future research and clinical translation. Studies are underway investigating utility of plasma NfL in diverse neurodegenerative and primary psychiatric conditions in real-world clinical settings. | |
| 650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Psykiatri0 (SwePub)302152 hsv//swe |
| 650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Psychiatry0 (SwePub)302152 hsv//eng |
| 650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Medicinska och farmaceutiska grundvetenskaperx Neurovetenskaper0 (SwePub)301052 hsv//swe |
| 650 | 7 | a MEDICAL AND HEALTH SCIENCESx Basic Medicinex Neurosciences0 (SwePub)301052 hsv//eng |
| 653 | a Behavioural variant frontotemporal dementia | |
| 653 | a bvFTD | |
| 653 | a diagnosis | |
| 653 | a neurofilament | |
| 653 | a psychiatry | |
| 653 | a psychiatric disorders | |
| 653 | a bipolar | |
| 653 | a depression | |
| 653 | a schizophrenia | |
| 653 | a major depressive disorder | |
| 653 | a chain | |
| 653 | a Psychiatry | |
| 700 | 1 | a Kang, M.u Royal Melbourne Hospital,University of Melbourne4 aut |
| 700 | 1 | a Malpas, C.u Royal Melbourne Hospital,University of Melbourne4 aut |
| 700 | 1 | a Simpson-Yap, S.u Royal Melbourne Hospital,University of Melbourne4 aut |
| 700 | 1 | a Lewis, C.u University of Melbourne,Royal Melbourne Hospital4 aut |
| 700 | 1 | a Dang, C.u University of Melbourne,National Ageing Research Institute, Australia4 aut |
| 700 | 1 | a Grewal, J.u Alfred Hospital4 aut |
| 700 | 1 | a Coe, A.u University of Melbourne4 aut |
| 700 | 1 | a Dobson, H.u Royal Melbourne Hospital,University of Melbourne4 aut |
| 700 | 1 | a Keem, M.u Royal Melbourne Hospital4 aut |
| 700 | 1 | a Chiu, W. H.u University of Melbourne4 aut |
| 700 | 1 | a Kalincik, T.u University of Melbourne,Royal Melbourne Hospital4 aut |
| 700 | 1 | a Ooi, S.u The Florey Institute of Neuroscience and Mental Health,University of Melbourne,Royal Melbourne Hospital4 aut |
| 700 | 1 | a Darby, D.u Alfred Health,Box Hill Hospital,Monash University4 aut |
| 700 | 1 | a Brodtmann, A.u Royal Melbourne Hospital,Monash University,Box Hill Hospital4 aut |
| 700 | 1 | a Hansson, Oskaru Lund University,Lunds universitet,Klinisk minnesforskning,Forskargrupper vid Lunds universitet,LU profilområde: Proaktivt åldrande,Lunds universitets profilområden,Clinical Memory Research,Lund University Research Groups,LU Profile Area: Proactive Ageing,Lund University Profile areas,Skåne University Hospital4 aut0 (Swepub:lu)mphy-ohn |
| 700 | 1 | a Janelidze, Shorenau Lund University,Lunds universitet,Klinisk minnesforskning,Forskargrupper vid Lunds universitet,LU profilområde: Proaktivt åldrande,Lunds universitets profilområden,Clinical Memory Research,Lund University Research Groups,LU Profile Area: Proactive Ageing,Lund University Profile areas4 aut0 (Swepub:lu)nkir-sje |
| 700 | 1 | a Blennow, Kaj,d 1958u University of Gothenburg,Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry,Sahlgrenska University Hospital4 aut0 (Swepub:lu)med-kbw |
| 700 | 1 | a Zetterberg, Henrik,d 1973u University of Gothenburg,Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry,Sahlgrenska University Hospital,Hong Kong Center for Neurodegenerative Diseases,University College London,University of Wisconsin-Madison4 aut0 (Swepub:lu)med-hiz |
| 700 | 1 | a Walker, A.u Deakin University4 aut |
| 700 | 1 | a Dean, O.u Deakin University4 aut |
| 700 | 1 | a Berk, M.u Deakin University4 aut |
| 700 | 1 | a Wannan, C.u University of Melbourne,Orygen - National Centre for Excellence in Youth Mental Health4 aut |
| 700 | 1 | a Pantelis, C.u University of Melbourne,Sunshine Hospital, St Albans4 aut |
| 700 | 1 | a Loi, S. M.4 aut |
| 700 | 1 | a Walterfang, M.u Royal Melbourne Hospital,University of Melbourne4 aut |
| 700 | 1 | a Berkovic, S. F.u University of Melbourne4 aut |
| 700 | 1 | a Santillo, Alexander F.u Lund University,Lunds universitet,Klinisk minnesforskning,Forskargrupper vid Lunds universitet,LU profilområde: Proaktivt åldrande,Lunds universitets profilområden,Clinical Memory Research,Lund University Research Groups,LU Profile Area: Proactive Ageing,Lund University Profile areas4 aut0 (Swepub:lu)med-ast |
| 700 | 1 | a Velakoulis, D.u University of Melbourne,Royal Melbourne Hospital4 aut |
| 700 | 1 | a Mi, N. D. Study Grp4 aut |
| 710 | 2 | a University of Melbourneb Royal Melbourne Hospital4 org |
| 773 | 0 | t Australian and New Zealand Journal of Psychiatryg 58:1, s. 70-81q 58:1<70-81x 0004-8674 |
| 856 | 4 | u http://dx.doi.org/10.1177/00048674231187312y FULLTEXT |
| 856 | 4 8 | u https://gup.ub.gu.se/publication/328478 |
| 856 | 4 8 | u https://doi.org/10.1177/00048674231187312 |
| 856 | 4 8 | u https://lup.lub.lu.se/record/414814e7-8b27-466b-8ad0-6ad9f8eaedcd |
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