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Circulating Osteopo...
Circulating Osteopontin and Prediction of Hepatocellular Carcinoma Development in a Large European Population
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- Duarte-Salles, Talita (author)
- Institut Universitari d’Investigació en Atenció Primària Jordi Gol
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- Misra, Sandeep (author)
- University of Texas
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- Stepien, Magdalena (author)
- International Agency for Research on Cancer, World Health Organization
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- Plymoth, Amelie (author)
- Karolinska Institutet,Karolinska Institute
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- Muller, David (author)
- International Agency for Research on Cancer, World Health Organization
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- Overvad, Kim (author)
- Aarhus University
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- Olsen, Anja (author)
- Danish Cancer Society
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- Tjonneland, Anne (author)
- Danish Cancer Society
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- Baglietto, Laura (author)
- University of Melbourne
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- Severi, Gianluca (author)
- Human Genetics Foundation (HuGeF)
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- Boutron-Ruault, Marie-Christine (author)
- Stabilite genetique et oncogenese
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- Turzanski-Fortner, Renee (author)
- German Cancer Research Centre
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- Kaaks, Rudolf (author)
- German Cancer Research Centre
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- Boeing, Heiner (author)
- German Institute of Human Nutrition,University of Malaya
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- Aleksandrova, Krasimira (author)
- German Institute of Human Nutrition
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- Trichopoulou, Antonia (author)
- National and Kapodistrian University of Athens
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- Lagiou, Pagona (author)
- National and Kapodistrian University of Athens
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- Bamia, Christina (author)
- National and Kapodistrian University of Athens
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- Pala, Valeria (author)
- Istituto Nazionale dei Tumori
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- Palli, Domenico (author)
- Cancer Research and Prevention Institute (ISPO)
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- Mattiello, Amalia (author)
- University of Naples Federico II
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- Tumino, Rosario (author)
- Civic and M.P Arezzo Hospital
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- Naccarati, Alessio (author)
- Human Genetics Foundation (HuGeF)
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Bueno-de-Mesquita, H. B(as). (author)
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- Peeters, Petra H. (author)
- Imperial College London
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- Weiderpass, Elisabete (author)
- Karolinska Institutet
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- Quiros, J. Ramon (author)
- Public Health Directorate
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- Agudo, Antonio (author)
- Bellvitge University Hospital-IDIBELL
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- Sanchez-Cantalejo, Emilio (author)
- CIBER Epidemiology and Public Health (CIBERESP)
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- Ardanaz, Eva (author)
- Health Research Institute of Navarra (IDISNA),CIBER Epidemiology and Public Health (CIBERESP)
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- Gavrila, Diana (author)
- Murcia Regional Health Council
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- Dorronsoro, Miren (author)
- CIBER Epidemiology and Public Health (CIBERESP)
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- Werner, Mårten (author)
- Umeå University,Umeå universitet,Medicin
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- Hemmingsson, Oskar (author)
- Umeå University,Umeå universitet,Kirurgi
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- Ohlsson, Bodil (author)
- Lund University,Lunds universitet,Internmedicin - epidemiologi,Forskargrupper vid Lunds universitet,Internal Medicine - Epidemiology,Lund University Research Groups,Skåne University Hospital
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- Sjöberg, Klas (author)
- Lund University,Lunds universitet,Gastroenterologi,Forskargrupper vid Lunds universitet,Gastroenterology,Lund University Research Groups,Skåne University Hospital
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- Wareham, Nicholas J. (author)
- Addenbrooke's Hospital
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- Khaw, Kay-Tee (author)
- University of Cambridge
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- Bradbury, Kathryn E. (author)
- University of Oxford
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- Gunter, Marc J. (author)
- Imperial College London
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- Cross, Amanda J. (author)
- Imperial College London,International Agency for Research on Cancer, World Health Organization
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- Riboli, Elio (author)
- Imperial College London
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Jenab, Mazda (author)
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- Hainaut, Pierre (author)
- University Grenoble Alpes
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- Beretta, Laura (author)
- University of Texas
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(creator_code:org_t)
- 2016
- 2016
- English.
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In: Cancer Prevention Research. - 1940-6207 .- 1940-6215. ; 9:9, s. 758-765
- Related links:
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http://dx.doi.org/10...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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https://lup.lub.lu.s...
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http://kipublication...
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Abstract
Subject headings
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- We previously identified osteopontin (OPN) as a promising marker for the early detection of hepatocellular carcinoma (HCC). In this study, we investigated the association between prediagnostic circulating OPN levels and HCC incidence in a large population-based cohort. A nested case-control study was conducted within the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort. During a mean follow-up of 4.8 years, 100 HCC cases were identified. Each case was matched to two controls and OPN levels were measured in baseline plasma samples. Viral hepatitis, liver function, and a-fetoprotein (AFP) tests were also conducted. Conditional logistic regression models were used to calculate multivariable odds ratio (OR) and 95% confidence intervals (95% CI) for OPN levels in relation to HCC. Receiver operating characteristics curves were constructed to determine the discriminatory accuracy of OPN alone or in combination with other liver biomarkers in the prediction of HCC. OPN levels were positively associated with HCC risk (per 10% increment, ORmultivariable = 1.30; 95% CI, 1.14-1.48). The association was stronger among cases diagnosed within 2 years of follow-up. Adding liver function tests to OPN improved the discriminatory performance for subjects who developed HCC (AUC = 0.86). For cases diagnosed within 2 years, the combination of OPN and AFP was best able to predict HCC risk (AUC = 0.88). The best predictive model for HCC in this low-risk population is OPN in combination with liver function tests. Within 2 years of diagnosis, the combination of OPN and AFP best predicted HCC development, suggesting that measuring OPN and AFP could identify high-risk groups independently of a liver disease diagnosis.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Kirurgi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Surgery (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Duarte-Salles, T ...
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Misra, Sandeep
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Stepien, Magdale ...
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Plymoth, Amelie
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Muller, David
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Overvad, Kim
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show more...
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Olsen, Anja
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Tjonneland, Anne
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Baglietto, Laura
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Severi, Gianluca
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Boutron-Ruault, ...
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Turzanski-Fortne ...
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Kaaks, Rudolf
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Boeing, Heiner
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Aleksandrova, Kr ...
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Trichopoulou, An ...
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Lagiou, Pagona
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Bamia, Christina
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Pala, Valeria
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Palli, Domenico
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Mattiello, Amali ...
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Tumino, Rosario
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Naccarati, Aless ...
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Bueno-de-Mesquit ...
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Peeters, Petra H ...
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Weiderpass, Elis ...
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Quiros, J. Ramon
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Agudo, Antonio
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Sanchez-Cantalej ...
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Ardanaz, Eva
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Gavrila, Diana
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Dorronsoro, Mire ...
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Werner, Mårten
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Hemmingsson, Osk ...
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Ohlsson, Bodil
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Sjöberg, Klas
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Wareham, Nichola ...
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Khaw, Kay-Tee
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Bradbury, Kathry ...
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Gunter, Marc J.
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Cross, Amanda J.
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Riboli, Elio
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Jenab, Mazda
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Hainaut, Pierre
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Beretta, Laura
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Surgery
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Cancer and Oncol ...
- Articles in the publication
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Cancer Preventio ...
- By the university
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Umeå University
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Lund University
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Karolinska Institutet