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Sökning: WFRF:(Colombo Antonio) > (2020-2022) > Geographic disparit...

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FältnamnIndikatorerMetadata
00005781naa a2200553 4500
001oai:DiVA.org:uu-488572
003SwePub
008221118s2022 | |||||||||||000 ||eng|
0247 a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-4885722 URI
0247 a https://doi.org/10.1016/j.ijcard.2022.08.0132 DOI
040 a (SwePub)uu
041 a engb eng
042 9 SwePub
072 7a ref2 swepub-contenttype
072 7a art2 swepub-publicationtype
1001 a Kageyama, Shigetakau Natl Univ Ireland, Dept Cardiol, Galway NUIG, Galway, Ireland.4 aut
2451 0a Geographic disparity in 10-year mortality after coronary artery revascularization in the SYNTAXES trial
264 1b Elsevier,c 2022
338 a print2 rdacarrier
520 a Aims: To investigate geographic disparity in long-term mortality following revascularization in patients with complex coronary artery disease (CAD).Methods and results: The SYNTAXES trial randomized 1800 patients with three-vessel and/or left main CAD to percutaneous coronary intervention (PCI) or coronary artery bypass grafting (CABG) and assessed their survival at 10 years. Patients were stratified according to the region of recruitment: North America (N-A, n = 245), Eastern Europe (E-E, n = 189), Northern Europe (N-E, n = 425), Southern Europe (S-E, n = 263), and Western Europe (W-E, n = 678), which also served as the reference group. Compared to W-E, patients were younger in E-E (62 vs 65 years, p < 0.001), and less frequently male in N-A (65.3% vs 79.6%, p < 0.001). Diabetes (16.0% vs 25.4%, p < 0.001) and peripheral vascular disease (6.8% vs 10.9%, p = 0.025) were less frequent in N-E than W-E. Ejection fraction was highest in W-E (62% vs 56%, p < 0.001). Compared to W-E, the mean anatomic SYNTAX score was higher in S-E (29 vs 31, p = 0.008) and lower in N-A (26, p < 0.001). Crude ten-year mortality was similar in N-A (31.6%), and W-E (30.7%), and significantly lower in E-E (22.5%, p = 0.041), N-E (21.9%, p = 0.003) and S-E (22.0%, p = 0.014). Compared to W-E, adjusted mortality in N-E (HR 0.85, p = 0.019) and S-E (HR 0.72, p = 0.043) remain significantly lower after adjustment for pre-and peri-procedural factors, but no significant interaction (Pinteraction = 0.728) between region and modality of revascularization was seen.Conclusion: In the era of globalization, knowledge, and understanding of geographic disparity are of paramount importance for the correct interpretation of global studies.
650 7a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Kardiologi0 (SwePub)302062 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Cardiac and Cardiovascular Systems0 (SwePub)302062 hsv//eng
653 a Geographic disparity
653 a Revascularization
653 a Complex coronary artery disease
653 a Ten-year mortality
7001 a Serruys, Patrick W.u Natl Univ Ireland, Dept Cardiol, Galway NUIG, Galway, Ireland.;Imperial Coll London, Natl Heart & Lung Inst, London, England.4 aut
7001 a Garg, Scotu Royal Blackburn Hosp, Dept Cardiol, Blackburn, Lancs, England.4 aut
7001 a Ninomiya, Kaiu Natl Univ Ireland, Dept Cardiol, Galway NUIG, Galway, Ireland.4 aut
7001 a Masuda, Shinichirou Natl Univ Ireland, Dept Cardiol, Galway NUIG, Galway, Ireland.4 aut
7001 a Kotoku, Nozomiu Natl Univ Ireland, Dept Cardiol, Galway NUIG, Galway, Ireland.4 aut
7001 a Colombo, Antoniou Humanitas Univ, Dept Biomed Sci, Pieve Emanuele Milan, Italy.;Humanitas Clin & Res Ctr IRCCS, Rozzano Milan, Italy.4 aut
7001 a Mack, Michael J.u Baylor Univ, Med Ctr, Dept Cardiothorac Surg, Dallas, TX USA.4 aut
7001 a Banning, Adrian P.u Oxford Univ Hosp, John Radcliffe Hosp, Dept Cardiol, Oxford, England.4 aut
7001 a Morice, Marie-Claudeu Hop Prive Jacques Cartier, Gen Sante Massy, Dept Cardiol, Massy, France.4 aut
7001 a Witkowski, Adamu Natl Inst Cardiol, Dept Intervent Cardiol & Angiol, Warsaw, Poland.4 aut
7001 a Curzen, Nicku Univ Southampton, Fac Med, Southampton, Hants, England.;Univ Hosp Southampton NHS Trust, Cardiothorac Unit, Southampton, Hants, England.4 aut
7001 a Burzotta, Francescou Univ Cattolica Sacro Cuore, Fdn Policlin Univ A Gemelli IRCCS, Inst Cardiol, Rome, Italy.4 aut
7001 a James, Stefan,d 1964-u Uppsala universitet,Institutionen för medicinska vetenskaper4 aut0 (Swepub:uu)stjam367
7001 a van Geuns, Robert-Janu Radboud Univ Nijmegen, Dept Cardiol, Med Ctr, Nijmegen, Netherlands.4 aut
7001 a Davierwala, Piroze M.u Univ Toronto, Dept Surg, Toronto, ON, Canada.;Toronto Gen Hosp, Peter Munk Cardiac Ctr, Div Cardiovasc Surg, Toronto, ON, Canada.;Univ Hlth Network, Toronto, ON, Canada.4 aut
7001 a Holmes, David R., Jr.u Mayo Clin, Dept Cardiovasc Dis & Internal Med, Rochester, MN USA.4 aut
7001 a Wood, David A.u Imperial Coll London, Natl Heart & Lung Inst, London, England.;Natl Univ Ireland, Natl Inst Prevent & Cardiovasc Hlth, Galway, Ireland.4 aut
7001 a McEvoy, John Williamu Natl Univ Ireland, Dept Cardiol, Galway NUIG, Galway, Ireland.;Natl Univ Ireland, Natl Inst Prevent & Cardiovasc Hlth, Galway, Ireland.4 aut
7001 a Onuma, Yoshinobuu Natl Univ Ireland, Dept Cardiol, Galway NUIG, Galway, Ireland.4 aut
7102 a Natl Univ Ireland, Dept Cardiol, Galway NUIG, Galway, Ireland.b Natl Univ Ireland, Dept Cardiol, Galway NUIG, Galway, Ireland.;Imperial Coll London, Natl Heart & Lung Inst, London, England.4 org
7730 t International Journal of Cardiologyd : Elsevierg 368, s. 28-38q 368<28-38x 0167-5273x 1874-1754
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-488572
8564 8u https://doi.org/10.1016/j.ijcard.2022.08.013

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