Integrated metagenomics/metaproteomics reveals human host-microbiota signatures of Crohn's disease

Erickson, Alison R (author)

Cantarel, Brandi L (author)

Lamendella, Regina (author)

Darzi, Youssef (author)

Mongodin, Emmanuel F (author)

Pan, Chongle (author)

Shah, Manesh (author)

Halfvarson, Jonas, 1970- (author): Örebro universitet,Institutionen för hälsovetenskap och medicin,Department of Internal Medicine, Division of Gastroenterology, Örebro University Hospital, Örebro, Sweden

Tysk, Curt, 1949- (author): Örebro universitet,Institutionen för hälsovetenskap och medicin,Department of Internal Medicine, Division of Gastroenterology, Örebro University Hospital, Örebro, Sweden

Henrissat, Bernard (author)

Raes, Jeroen (author)

Verberkmoes, Nathan C (author)

Fraser, Claire M (author)

Hettich, Robert L (author)

Jansson, Janet K (author)

(creator_code:org_t)

2012-11-28
2012
English.
In: PLOS ONE. - San Francisco : Public Library Science. - 1932-6203. ; 7:11

Related links:: https://doi.org/10.1...; show more...; https://doi.org/10.1...; https://urn.kb.se/re...; https://doi.org/10.1...; show less...

Abstract Subject headings

Crohn's disease (CD) is an inflammatory bowel disease of complex etiology, although dysbiosis of the gut microbiota has been implicated in chronic immune-mediated inflammation associated with CD. Here we combined shotgun metagenomic and metaproteomic approaches to identify potential functional signatures of CD in stool samples from six twin pairs that were either healthy, or that had CD in the ileum (ICD) or colon (CCD). Integration of these omics approaches revealed several genes, proteins, and pathways that primarily differentiated ICD from healthy subjects, including depletion of many proteins in ICD. In addition, the ICD phenotype was associated with alterations in bacterial carbohydrate metabolism, bacterial-host interactions, as well as human host-secreted enzymes. This eco-systems biology approach underscores the link between the gut microbiota and functional alterations in the pathophysiology of Crohn's disease and aids in identification of novel diagnostic targets and disease specific biomarkers.

By the author/editor: Erickson, Alison ...; Cantarel, Brandi ...; Lamendella, Regi ...; Darzi, Youssef; Mongodin, Emmanu ...; Pan, Chongle; show more...; Shah, Manesh; Halfvarson, Jona ...; Tysk, Curt, 1949 ...; Henrissat, Berna ...; Raes, Jeroen; Verberkmoes, Nat ...; Fraser, Claire M; Hettich, Robert ...; Jansson, Janet K; show less...

About the subject

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.