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Exercise and intern...
Exercise and internet-based cognitive-behavioural therapy for depression : Multicentre randomized controlled trial with 12-month follow-up
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- Hallgren, Mats (författare)
- Karolinska Institutet,Division of Epidemiology and Public Health Intervention Research (EPHIR), Department of Public Health Sciences, Karolinska Institute, Solna, Sweden,Karolinska Institute, Stockholm, Sweden
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- Helgadóttir, Björg (författare)
- Karolinska Institutet,Division of Epidemiology and Public Health Intervention Research (EPHIR), Department of Public Health Sciences, Karolinska Institute, Solna, Sweden,Karolinska Institute, Stockholm, Sweden
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- Herring, Matthew P. (författare)
- Department of Physical Education and Sport Sciences, Health Research Institute, University of Limerick, Ireland,Univ Limerick, Ireland
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- Zeebari, Zangin (författare)
- Karolinska Institutet,Division of Epidemiology and Public Health Intervention Research (EPHIR), Department of Public Health Sciences, Karolinska Institute, Solna, Sweden,Karolinska Institute, Stockholm, Sweden
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- Lindefors, Nils (författare)
- Karolinska Institutet,Department of Clinical Neuroscience, Karolinska Institute, Huddinge, Sweden,Karolinska Institute, Stockholm, Sweden
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- Kaldo, Viktor (författare)
- Karolinska Institutet,Karolinska Institute, Stockholm, Sweden
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- Öjehagen, Agneta (författare)
- Lund University,Lunds universitet,Psykiatri, Lund,Sektion IV,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Psychiatry (Lund),Section IV,Department of Clinical Sciences, Lund,Faculty of Medicine,Department of Clinical Sciences, Psychiatry, Lund University, Lund, Sweden
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- Forsell, Yvonne (författare)
- Karolinska Institutet,Division of Epidemiology and Public Health Intervention Research (EPHIR), Department of Public Health Sciences, Karolinska Institute, Solna, Sweden,Karolinska Institute, Stockholm, Sweden
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(creator_code:org_t)
- 2018-01-02
- 2016
- Engelska.
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Ingår i: British Journal of Psychiatry. - : Cambridge University Press. - 0007-1250 .- 1472-1465. ; 209:5, s. 414-420
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Abstract
Ämnesord
Stäng
- Background Evidence-based treatment of depression continues to grow, but successful treatment and maintenance of treatment response remains limited.Aims To compare the effectiveness of exercise, internet-based cognitive-behavioural therapy (ICBT) and usual care for depression.Method A multicentre, three-group parallel, randomised controlled trial was conducted with assessment at 3 months (posttreatment) and 12 months (primary end-point). Outcome assessors were masked to group allocation. Computer-generated allocation was performed externally in blocks of 36 and the ratio of participants per group was 1:1:1. In total, 945 adults with mild to moderate depression aged 18-71 years were recruited from primary healthcare centres located throughout Sweden. Participants were randomly assigned to one of three 12-week interventions: supervised group exercise, clinician-supported ICBT or usual care by a physician. The primary outcome was depression severity assessed by the Montgomery-Åsberg Depression Rating Scale (MADRS).Results The response rate at 12-month follow-up was 84%. Depression severity reduced significantly in all three treatment groups in a quadratic trend over time. Mean differences in MADRS score at 12 months were 12.1 (ICBT), 11.4 (exercise) and 9.7 (usual care). At the primary end-point the group x time interaction was significant for both exercise and ICBT. Effect sizes for both interventions were small to moderate.Conclusions The long-term treatment effects reported here suggest that prescribed exercise and clinician-supported ICBT should be considered for the treatment of mild to moderate depression in adults.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Psykiatri (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Psychiatry (hsv//eng)
- SAMHÄLLSVETENSKAP -- Psykologi -- Tillämpad psykologi (hsv//swe)
- SOCIAL SCIENCES -- Psychology -- Applied Psychology (hsv//eng)
Nyckelord
- adult
- clinical trial
- cognitive behavioral therapy
- controlled clinical trial
- controlled study
- effect size
- exercise
- follow up
- human
- Internet
- major clinical study
- Montgomery Asberg Depression Rating Scale
- multicenter study
- physician
- primary health care
- randomized controlled trial
- Sweden
- young adult
- adolescent
- aged
- cognitive therapy
- comparative study
- depression
- female
- kinesiotherapy
- male
- middle aged
- outcome assessment
- procedures
- severity of illness index
- Exercise Therapy
- Follow-Up Studies
- Humans
- Outcome Assessment (Health Care)
- Psychology
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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