WFRF:(Gaunt Tom R.)
Sökning: WFRF:(Gaunt Tom R.) > (2010-2014) > Blood Pressure Loci...
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| Fältnamn | Indikatorer | Metadata |
|---|---|---|
| 000 | 09039naa a2201657 4500 | |
| 001 | oai:gup.ub.gu.se/149718 | |
| 003 | SwePub | |
| 008 | 240528s2011 | |||||||||||000 ||eng| | |
| 009 | oai:lup.lub.lu.se:803eaa07-4d42-4102-970a-a6066864541d | |
| 009 | oai:prod.swepub.kib.ki.se:123740960 | |
| 024 | 7 | a https://gup.ub.gu.se/publication/1497182 URI |
| 024 | 7 | a https://doi.org/10.1016/j.ajhg.2011.10.0132 DOI |
| 024 | 7 | a https://lup.lub.lu.se/record/23206532 URI |
| 024 | 7 | a http://kipublications.ki.se/Default.aspx?queryparsed=id:1237409602 URI |
| 040 | a (SwePub)gud (SwePub)lud (SwePub)ki | |
| 041 | a eng | |
| 042 | 9 SwePub | |
| 072 | 7 | a ref2 swepub-contenttype |
| 072 | 7 | a art2 swepub-publicationtype |
| 100 | 1 | a Johnson, Toby4 aut |
| 245 | 1 0 | a Blood Pressure Loci Identified with a Gene-Centric Array. |
| 264 | 1 | b Elsevier BV,c 2011 |
| 520 | a Raised blood pressure (BP) is a major risk factor for cardiovascular disease. Previous studies have identified 47 distinct genetic variants robustly associated with BP, but collectively these explain only a few percent of the heritability for BP phenotypes. To find additional BP loci, we used a bespoke gene-centric array to genotype an independent discovery sample of 25,118 individuals that combined hypertensive case-control and general population samples. We followed up four SNPs associated with BP at our p < 8.56× 10(-7) study-specific significance threshold and six suggestively associated SNPs in a further 59,349 individuals. We identified and replicated a SNP at LSP1/TNNT3, a SNP at MTHFR-NPPB independent (r(2) = 0.33) of previous reports, and replicated SNPs at AGT and ATP2B1 reported previously. An analysis of combined discovery and follow-up data identified SNPs significantly associated with BP at p < 8.56× 10(-7) at four further loci (NPR3, HFE, NOS3, and SOX6). The high number of discoveries made with modest genotyping effort can be attributed to using a large-scale yet targeted genotyping array and to the development of a weighting scheme that maximized power when meta-analyzing results from samples ascertained with extreme phenotypes, in combination with results from nonascertained or population samples. Chromatin immunoprecipitation and transcript expression data highlight potential gene regulatory mechanisms at the MTHFR and NOS3 loci. These results provide candidates for further study to help dissect mechanisms affecting BP and highlight the utility of studying SNPs and samples that are independent of those studied previously even when the sample size is smaller than that in previous studies. | |
| 650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Medicinska och farmaceutiska grundvetenskaperx Medicinsk genetik0 (SwePub)301072 hsv//swe |
| 650 | 7 | a MEDICAL AND HEALTH SCIENCESx Basic Medicinex Medical Genetics0 (SwePub)301072 hsv//eng |
| 650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Kardiologi0 (SwePub)302062 hsv//swe |
| 650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Cardiac and Cardiovascular Systems0 (SwePub)302062 hsv//eng |
| 650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Hälsovetenskapx Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi0 (SwePub)303022 hsv//swe |
| 650 | 7 | a MEDICAL AND HEALTH SCIENCESx Health Sciencesx Public Health, Global Health, Social Medicine and Epidemiology0 (SwePub)303022 hsv//eng |
| 700 | 1 | a Gaunt, Tom R4 aut |
| 700 | 1 | a Newhouse, Stephen J4 aut |
| 700 | 1 | a Padmanabhan, Sandosh4 aut |
| 700 | 1 | a Tomaszewski, Maciej4 aut |
| 700 | 1 | a Kumari, Meena4 aut |
| 700 | 1 | a Morris, Richard W4 aut |
| 700 | 1 | a Tzoulaki, Ioanna4 aut |
| 700 | 1 | a O'Brien, Eoin T4 aut |
| 700 | 1 | a Poulter, Neil R4 aut |
| 700 | 1 | a Sever, Peter4 aut |
| 700 | 1 | a Shields, Denis C4 aut |
| 700 | 1 | a Thom, Simon4 aut |
| 700 | 1 | a Wannamethee, Sasiwarang G4 aut |
| 700 | 1 | a Whincup, Peter H4 aut |
| 700 | 1 | a Brown, Morris J4 aut |
| 700 | 1 | a Connell, John M4 aut |
| 700 | 1 | a Dobson, Richard J4 aut |
| 700 | 1 | a Howard, Philip J4 aut |
| 700 | 1 | a Mein, Charles A4 aut |
| 700 | 1 | a Onipinla, Abiodun4 aut |
| 700 | 1 | a Shaw-Hawkins, Sue4 aut |
| 700 | 1 | a Zhang, Yun4 aut |
| 700 | 1 | a Smith, George Davey4 aut |
| 700 | 1 | a Day, Ian N M4 aut |
| 700 | 1 | a Lawlor, Debbie A4 aut |
| 700 | 1 | a Goodall, Alison Hu Karolinska Institutet4 aut |
| 700 | 1 | a Fowkes, F Gerald4 aut |
| 700 | 1 | a Abecasis, Gonçalo R4 aut |
| 700 | 1 | a Elliott, Paul4 aut |
| 700 | 1 | a Gateva, Vesela4 aut |
| 700 | 1 | a Braund, Peter S4 aut |
| 700 | 1 | a Burton, Paul R4 aut |
| 700 | 1 | a Nelson, Christopher P4 aut |
| 700 | 1 | a Tobin, Martin D4 aut |
| 700 | 1 | a van der Harst, Pim4 aut |
| 700 | 1 | a Glorioso, Nicola4 aut |
| 700 | 1 | a Neuvrith, Hani4 aut |
| 700 | 1 | a Salvi, Erika4 aut |
| 700 | 1 | a Staessen, Jan A4 aut |
| 700 | 1 | a Stucchi, Andrea4 aut |
| 700 | 1 | a Devos, Nabila4 aut |
| 700 | 1 | a Jeunemaitre, Xavier4 aut |
| 700 | 1 | a Plouin, Pierre-François4 aut |
| 700 | 1 | a Tichet, Jean4 aut |
| 700 | 1 | a Juhanson, Peeter4 aut |
| 700 | 1 | a Org, Elin4 aut |
| 700 | 1 | a Putku, Margus4 aut |
| 700 | 1 | a Sõber, Siim4 aut |
| 700 | 1 | a Veldre, Gudrun4 aut |
| 700 | 1 | a Viigimaa, Margus4 aut |
| 700 | 1 | a Levinsson, Annau Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för samhällsmedicin och folkhälsa,Institute of Medicine, School of Public Health and Community Medicine4 aut |
| 700 | 1 | a Rosengren, Annika,d 1951u Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för akut och kardiovaskulär medicin,Institute of Medicine, Department of Emergeny and Cardiovascular Medicine4 aut0 (Swepub:gu)xrosan |
| 700 | 1 | a Thelle, Dag,d 19424 aut |
| 700 | 1 | a Hastie, Claire E4 aut |
| 700 | 1 | a Hedner, Thomas,d 1949u Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för invärtesmedicin,Institute of Medicine, Department of Internal Medicine4 aut0 (Swepub:gu)xhedto |
| 700 | 1 | a Lee, Wai K4 aut |
| 700 | 1 | a Melander, Olleu Lund University,Lunds universitet,Kardiovaskulär forskning - hypertoni,Forskargrupper vid Lunds universitet,Cardiovascular Research - Hypertension,Lund University Research Groups4 aut0 (Swepub:lu)endo-ome |
| 700 | 1 | a Wahlstrand, Björn,d 1970u Gothenburg University,Göteborgs universitet,Institutionen för medicin,Institute of Medicine4 aut0 (Swepub:gu)xwahlb |
| 700 | 1 | a Hardy, Rebecca4 aut |
| 700 | 1 | a Wong, Andrew4 aut |
| 700 | 1 | a Cooper, Jackie A4 aut |
| 700 | 1 | a Palmen, Jutta4 aut |
| 700 | 1 | a Chen, Li4 aut |
| 700 | 1 | a Stewart, Alexandre F R4 aut |
| 700 | 1 | a Wells, George A4 aut |
| 700 | 1 | a Westra, Harm-Jan4 aut |
| 700 | 1 | a Wolfs, Marcel G M4 aut |
| 700 | 1 | a Clarke, Robert4 aut |
| 700 | 1 | a Franzosi, Maria Grazia4 aut |
| 700 | 1 | a Goel, Anuj4 aut |
| 700 | 1 | a Hamsten, Anders4 aut |
| 700 | 1 | a Lathrop, Mark4 aut |
| 700 | 1 | a Peden, John F4 aut |
| 700 | 1 | a Seedorf, Udo4 aut |
| 700 | 1 | a Watkins, Hugh4 aut |
| 700 | 1 | a Ouwehand, Willem H4 aut |
| 700 | 1 | a Sambrook, Jennifer4 aut |
| 700 | 1 | a Stephens, Jonathan4 aut |
| 700 | 1 | a Casas, Juan-Pablo4 aut |
| 700 | 1 | a Drenos, Fotios4 aut |
| 700 | 1 | a Holmes, Michael V4 aut |
| 700 | 1 | a Kivimaki, Mika4 aut |
| 700 | 1 | a Shah, Sonia4 aut |
| 700 | 1 | a Shah, Tina4 aut |
| 700 | 1 | a Talmud, Philippa J4 aut |
| 700 | 1 | a Whittaker, John4 aut |
| 700 | 1 | a Wallace, Chris4 aut |
| 700 | 1 | a Delles, Christian4 aut |
| 700 | 1 | a Laan, Maris4 aut |
| 700 | 1 | a Kuh, Diana4 aut |
| 700 | 1 | a Humphries, Steve E4 aut |
| 700 | 1 | a Nyberg, Fredrik,d 1961u Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för samhällsmedicin och folkhälsa,Institute of Medicine, School of Public Health and Community Medicine4 aut0 (Swepub:gu)xnybef |
| 700 | 1 | a Cusi, Daniele4 aut |
| 700 | 1 | a Roberts, Robert4 aut |
| 700 | 1 | a Newton-Cheh, Christopher4 aut |
| 700 | 1 | a Franke, Lude4 aut |
| 700 | 1 | a Stanton, Alice V4 aut |
| 700 | 1 | a Dominiczak, Anna F4 aut |
| 700 | 1 | a Farrall, Martin4 aut |
| 700 | 1 | a Hingorani, Aroon D4 aut |
| 700 | 1 | a Samani, Nilesh J4 aut |
| 700 | 1 | a Caulfield, Mark J4 aut |
| 700 | 1 | a Munroe, Patricia B4 aut |
| 700 | 1 | a Laan, Mans4 aut |
| 710 | 2 | a Karolinska Institutetb Institutionen för medicin, avdelningen för samhällsmedicin och folkhälsa4 org |
| 773 | 0 | t American Journal of Human Geneticsd : Elsevier BVg 89:6, s. 688-700q 89:6<688-700x 1537-6605x 0002-9297 |
| 856 | 4 | u http://www.cell.com/article/S0002929711004472/pdf |
| 856 | 4 | u http://dx.doi.org/10.1016/j.ajhg.2011.10.013y FULLTEXT |
| 856 | 4 8 | u https://gup.ub.gu.se/publication/149718 |
| 856 | 4 8 | u https://doi.org/10.1016/j.ajhg.2011.10.013 |
| 856 | 4 8 | u https://lup.lub.lu.se/record/2320653 |
| 856 | 4 8 | u http://kipublications.ki.se/Default.aspx?queryparsed=id:123740960 |
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