WFRF:(Ghanipour Lana)
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No Indication for Routine Resection of Surgical Scars during Cytoreductive Surgery and HIPEC
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- Enblad, Malin (författare)
- Uppsala universitet,Gastrointestinalkirurgi,Colorectal surgery
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- Ghanipour, Lana (författare)
- Uppsala universitet,Gastrointestinalkirurgi,Colorectal surgery
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- Cashin, Peter, 1984- (författare)
- Uppsala universitet,Gastrointestinalkirurgi,Colorectal surgery
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- MDPI, 2024
- 2024
- Engelska.
- Ingår i: Cancers. - : MDPI. - 2072-6694. ; 16:11
- Tidskriftsartikel (refereegranskat)
Abstract
Ämnesord
Stäng
- Background: Careful macroscopic assessment of surgical scars is needed to avoid routine scar resection during cytoreductive surgery (CRS) for peritoneal metastases (PM). This study aimed to analyze the correlation between macroscopically suspected and microscopically confirmed scar metastases (SMs), and to analyze the prognostic impact of not undergoing routine scar resection.Method: All patients with previous surgery, treated with CRS and hyperthermic intraperitoneal chemotherapy, for colorectal PM or pseudomyxoma peritonei (PMP), at Uppsala University Hospital in 2013–2021, were included. Macroscopic SMs in surgical reports were compared with histopathological analyses.Results: In total, 227 patients were included. Among colorectal PM patients (n = 156), SM was macroscopically suspected in 41 (26%) patients, and 63 (40%) underwent scar resection. SM was confirmed in 19 (30%). Among patients with macroscopic suspicion, 45% had confirmed SM (positive predictive value, PPV). A total of 1 of 23 (4%) patients with no macroscopic suspicion had SM (negative predictive value, NPV = 96%). Among the PMP patients (n = 71), SM was macroscopically suspected in 13 (18%), and 28 (39%) underwent scar resection, of whom 12 (43%) had SM. The PPV was 77%. Occult SM was found in 1 of 14 (NPV = 93%). Not undergoing routine scar resection did not affect recurrence-free survival (RFS, p = 0.2) or overall survival (OS, p = 0.1) in colorectal PM patients or PMP patients (RFS p = 0.7, OS p = 0.7).Conclusion: Occult SM is uncommon and scar resection does not affect RFS or OS. Therefore, macroscopically benign-appearing scars can be left without resection, though resection should be performed upon suspicion or uncertainty.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Kirurgi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Surgery (hsv//eng)
Nyckelord
- scar metastases
- peritoneal metastases
- cytoreductive surgery
- HIPEC
- pseudomyxoma peritonei
- colorectal cancer
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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- Av författaren/redakt...
- Enblad, Malin
- Ghanipour, Lana
- Cashin, Peter, 1 ...
- Birgisson, Helgi
- Graf, Wilhelm
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- MEDICIN OCH HÄLSOVETENSKAP
- MEDICIN OCH HÄLS ...
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- och Kirurgi
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- Cancers
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- Uppsala universitet
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