Synthesis of trifluoromethyl moieties by late-stage copper (I) mediated nucleophilic fluorination

• The nucleophilic fluorination of bromodifluoromethyl derivatives mediated by the complex (PPh3)(3)CuF is described. Under the reaction conditions, different trifluoroacetates, trifluorolcetones, trifluoroarenes and trifluoroacetamides were obtained in good yields.

Ämnesord

NATURVETENSKAP  -- Kemi -- Organisk kemi (hsv//swe)

NATURAL SCIENCES  -- Chemical Sciences -- Organic Chemistry (hsv//eng)

Nyckelord

Nucleophilic fluorination

Copper

Trifluoroacetate

Trifluoromethylarene

Trifluoroacetamide

organisk kemi

Organic Chemistry

Publikations- och innehållstyp

ref (ämneskategori)

art (ämneskategori)