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LIBRIS Formathandbok  (Information om MARC21)
FältnamnIndikatorerMetadata
00005506naa a2200613 4500
001oai:lup.lub.lu.se:41db50e3-4cf4-411b-9ffc-d794e4b75f62
003SwePub
008160401s2013 | |||||||||||000 ||eng|
009oai:DiVA.org:liu-104751
0247 a https://lup.lub.lu.se/record/40426202 URI
0247 a https://doi.org/10.1159/0003516382 DOI
0247 a https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-1047512 URI
040 a (SwePub)lud (SwePub)liu
041 a engb eng
042 9 SwePub
072 7a art2 swepub-publicationtype
072 7a ref2 swepub-contenttype
1001 a Verder, Henriku Department of Pediatrics, Holbæk Hospital, Holbæk, Denmark4 aut
2451 0a Early Surfactant Guided by Lamellar Body Counts on Gastric Aspirate in Very Preterm Infants
264 c 2013-07-09
264 1b S. Karger AG,c 2013
520 a Background: We have developed a rapid method, based on lamellar body counts (LBC) on gastric aspirate, for identifying newborns who will develop respiratory distress syndrome with a need for surfactant supplementation. Objective: We set out to test whether it was possible to improve the outcome when used in a clinical trial. Methods: We randomly assigned 380 infants born at 24-29 weeks' gestation and supported with nasal continuous positive airway pressure (nCPAP) to receive surfactant guided either by LBC (intervention group) or increasing need for oxygen (control group). The primary outcome was mechanical ventilation or death within 5 days. Secondary outcomes included need for oxygen expressed by arterial to alveolar oxygen tension ratio (a/APO(2)) at the age of 6 h and need for oxygen at day 28. Results: The primary outcomes were equal (25%) in the two groups. The intervention group had higher a/APO(2) than the control group at 6 h, median 0.64 versus 0.52 (p < 0.01), and the subgroup with gestational age 26-29 weeks needed fewer days of oxygen supplementation than the controls, median 2 vs. 9 days (p = 0.01), and fewer infants needed oxygen at day 28 (p = 0.04). Furthermore, there was a tendency in the intervention group towards a shorter duration of nCPAP. Too little or viscose aspirate in 23% of the cases was a limitation of the method. Conclusion: Using LBC test as indicator of lung maturity and early surfactant therapy in very preterm newborns, it is possible to reduce the need for oxygen supplementation. Copyright (C) 2013 S. Karger AG, Basel
650 7a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Pediatrik0 (SwePub)302212 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Pediatrics0 (SwePub)302212 hsv//eng
653 a Continuous positive airway pressure
653 a Nasal CPAP
653 a Premature infants
653 a Respiratory distress syndrome
653 a Pulmonary surfactant
653 a Lamellar bodies
653 a Continuous positive airway pressure; Nasal CPAP; Premature infants; Respiratory distress syndrome; Pulmonary surfactant; Lamellar bodies
7001 a Ebbesen, Finnu Department of Pediatrics, Aalborg Hospital, Aalborg, Denmark4 aut
7001 a Fenger-Gron, Jesperu Department of Pediatrics, Kolding Hospital, Aarhus University, Aarhus, Denmark4 aut
7001 a Henriksen, Tine Brinku Department of Pediatrics, Aarhus University Hospital, Skejby, Denmark4 aut
7001 a Andreasson, Bengtu Department of Neonatology, Malmö, Sweden4 aut
7001 a Bender, Larsu Department of Pediatrics, Aalborg Hospital, Aalborg, Denmark4 aut
7001 a Bertelsen, Akselu Department of Pediatrics, Holbæk Hospital, Holbæk, Denmark4 aut
7001 a Björklund, Larsu Lund University,Lunds universitet,Pediatrik, Lund,Sektion V,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Paediatrics (Lund),Section V,Department of Clinical Sciences, Lund,Faculty of Medicine,Department of Neonatology, Skåne University Hospital, University of Lund, Lund, Sweden4 aut0 (Swepub:lu)pedi-lbj
7001 a Dahl, Marianneu Department of Pediatrics, Odense Hospital, Odense, Denmark4 aut
7001 a Esberg, Gitteu Department of Pediatrics, Aarhus University Hospital, Skejby, Denmark4 aut
7001 a Eschen, Christianu Department of Pediatrics, Holbæk Hospital, Holbæk, Denmark4 aut
7001 a Hovring, Marieu Department of Pediatrics, Holbæk Hospital, Holbæk, Denmark4 aut
7001 a Kreft, Andreasu Department of Pediatrics, Sønderborg Hospital, University of South Denmark, Sønderborg, Denmark4 aut
7001 a Kroner, Jornu Department of Pediatrics, Odense Hospital, Odense, Denmark4 aut
7001 a Lundberg, Fredriku Department of Neonatology, Malmö, Sweden4 aut0 (Swepub:liu)frelu52
7001 a Pedersen, Pernilleu epartment of Pediatrics, Hvidovre Hospital, Hvidovre, Denmark4 aut
7001 a Reinholdt, Jesu Department of Neonatology, Rigshospitalet, Copenhagen, Denmark4 aut
7001 a Stanchev, Hristou Department of Pediatrics, University of Copenhagen, Næstved, Denmark4 aut
7102 a Department of Pediatrics, Holbæk Hospital, Holbæk, Denmarkb Department of Pediatrics, Aalborg Hospital, Aalborg, Denmark4 org
7730 t Neonatologyd : S. Karger AGg 104:2, s. 116-122q 104:2<116-122x 1661-7800x 1661-7819
8564 u http://dx.doi.org/10.1159/000351638y FULLTEXT
8564 8u https://lup.lub.lu.se/record/4042620
8564 8u https://doi.org/10.1159/000351638
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-104751

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