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Role of Endothelial...
Role of Endothelial Cell Lipoprotein Lipase for Brown Adipose Tissue Lipid and Glucose Handling
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- Thiemann, Ellen (författare)
- Department of Biochemistry and Molecular Cell Biology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany
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- Schwaerzer, Gerburg K. (författare)
- Institute of Pharmacology and Toxicology, University Hospital, University of Bonn, Bonn, Germany
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- Evangelakos, Ioannis (författare)
- rsity Medical Center Hamburg-Eppendorf, Hamburg, Germany
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- Fuh, Marceline M. (författare)
- rsity Medical Center Hamburg-Eppendorf, Hamburg, Germany
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- Jaeckstein, Michelle Y. (författare)
- rsity Medical Center Hamburg-Eppendorf, Hamburg, Germany
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- Behrens, Janina (författare)
- rsity Medical Center Hamburg-Eppendorf, Hamburg, Germany
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- Nilsson, Stefan K., 1979- (författare)
- Umeå universitet,Fysiologisk kemi
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- Kumari, Manju (författare)
- Department of Biochemistry and Molecular Cell Biology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany; Department of Internal Medicine III, Heidelberg University, Heidelberg, Germany
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- Scheja, Ludger (författare)
- Department of Biochemistry and Molecular Cell Biology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany
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- Pfeifer, Alexander (författare)
- Institute of Pharmacology and Toxicology, University Hospital, University of Bonn, Bonn, Germany
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- Heeren, Joerg (författare)
- Department of Biochemistry and Molecular Cell Biology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany
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- Heine, Markus (författare)
- Department of Biochemistry and Molecular Cell Biology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany
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(creator_code:org_t)
- 2022-03-29
- 2022
- Engelska.
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Ingår i: Frontiers in Physiology. - : Frontiers Media S.A.. - 1664-042X. ; 13
- Relaterad länk:
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https://doi.org/10.3...
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https://umu.diva-por... (primary) (Raw object)
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https://urn.kb.se/re...
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https://doi.org/10.3...
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Abstract
Ämnesord
Stäng
- Cold-induced activation of brown adipose tissue (BAT) has an important impact on systemic lipoprotein metabolism by accelerating the processing of circulating triglyceride-rich lipoproteins (TRL). Lipoprotein lipase (LPL) expressed by adipocytes is translocated via endothelial to the capillary lumen, where LPL acts as the central enzyme for the vascular lipoprotein processing. Based on preliminary data showing that LPL is not only expressed in adipocytes but also in endothelial cells of cold-activated BAT, we aimed to dissect the relevance of endothelial versus adipocyte LPL for lipid and energy metabolism in the context of adaptive thermogenesis. By metabolic studies we found that cold-induced triglyceride uptake into BAT, lipoprotein disposal, glucose uptake and adaptive thermogenesis were not impaired in mice lacking Lpl exclusively in endothelial cells. This finding may be explained by a compensatory upregulation in the expression of adipocyte-derived Lpl and endothelial lipase (Lipg).
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Endokrinologi och diabetes (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Endocrinology and Diabetes (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Cell- och molekylärbiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Cell and Molecular Biology (hsv//eng)
Nyckelord
- lipoprotein lipase
- triglycerides
- endothelial cells
- adipocytes
- lipoproteins
- adipose tissue
- thermogenesis
- de novo lipogenesis
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Thiemann, Ellen
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Schwaerzer, Gerb ...
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Evangelakos, Ioa ...
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Fuh, Marceline M ...
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Jaeckstein, Mich ...
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Behrens, Janina
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Nilsson, Stefan ...
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Kumari, Manju
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Scheja, Ludger
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Pfeifer, Alexand ...
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Heeren, Joerg
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Heine, Markus
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visa färre...
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