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Increased carotid i...
Increased carotid intima-media thickness in patients with radiographic axial spondyloarthritis compared to controls and associations with markers of inflammation
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- Law, Lucy (author)
- Umeå University,Umeå universitet,Avdelningen för medicin
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- Lindqvist, Per (author)
- Umeå University,Umeå universitet,Klinisk fysiologi
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- Liv, Per, 1979- (author)
- Umeå University,Umeå universitet,Avdelningen för hållbar hälsa
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- Hellman, Urban, 1966- (author)
- Umeå universitet,Avdelningen för medicin
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- Lejon, Kristina, 1967- (author)
- Umeå University,Umeå universitet,Institutionen för klinisk mikrobiologi
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- Geijer, Mats, 1957 (author)
- Lund University,Lunds universitet,Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper, Avdelningen för radiologi,Institute of Clinical Sciences, Department of Radiology,Department of Radiology, Institute of Clinical Sciences, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden; Department of Radiology, Region Västra Götaland, Sahlgrenska University Hospital, Gothenburg, Sweden; Department of Clinical Sciences, Lund University, Lund, Sweden,Diagnostisk radiologi, Lund,Sektion V,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Diagnostic Radiology, (Lund),Section V,Department of Clinical Sciences, Lund,Faculty of Medicine
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- Söderberg, Stefan (author)
- Umeå University,Umeå universitet,Avdelningen för medicin
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- Forsblad d'Elia, Helena, 1961 (author)
- Umeå universitet,Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för reumatologi och inflammationsforskning,Institute of Medicine, Department of Rheumatology and Inflammation Research,Avdelningen för medicin,Department of Rheumatology and Inflammation Research, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden; Clinic of Rheumatology, Sahlgrenska University Hospital, Gothenburg, Sweden
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(creator_code:org_t)
- Springer Nature, 2024
- 2024
- English.
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In: CLINICAL RHEUMATOLOGY. - : Springer Nature. - 0770-3198 .- 1434-9949.
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Abstract
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- Objective There is an increased risk for cardiovascular disease (CVD) in patients with radiographic axial spondyloarthritis (r-axSpA). In this cross-sectional study, we aimed to, overall and stratified by sex, (i) compare ultrasound derived carotid intima media thickness (cIMT), between patients and controls, and (ii) investigate associations between cIMT, clinical disease activity and inflammation-related laboratory markers in patients with r-axSpA. Method In total, 155 patients diagnosed with r-axSpA using the modified New York criteria and 400 controls were included. Bilateral carotid ultrasound, laboratory testing, and questionaries were acquired. Disease-specific assessments were carried out for patients. Linear regression analysis was used to assess associations. Results Linear regression analyses showed that patients with r-axSpA had increased mean cIMT compared to controls (mean +/- SD, 0.8 +/- 0.1 mm vs 0.7 +/- 0.1 mm, respectively, unstandardized beta (95% CI) -0.076 (-0.10, -0.052), P < 0.001) adjusted for smoking status and age. Linear regression analyses for patients with r-axSpA showed that only males presented significant associations between cIMT and inflammation-related laboratory markers, white blood cell (WBC) count (mean +/- SD, 6.8 +/- 1.6 10(9)/L) and monocytes (0.6 +/- 0.2 10(9)/L); WBC count (unstandardized beta (95% CI) 0.019 (0.0065, 0.031), P = 0.003, R-2 = 0.57) and monocytes (0.13 (0.0047, 0.26), P = 0.041, R-2 = 0.55), adjusted for age, smoking status, body mass index, hypertension, dyslipidemia, diabetes mellitus, ASDAS-CRP, and treatment with DMARDs and glucocorticoids. No significant association was found between cIMT and clinical disease activity assessed by ASDAS-CRP. Conclusion Patients with r-axSpA had significantly increased cIMT compared to controls. In male patients, higher WBC and monocyte count were associated with an increase in cIMT suggesting the role of inflammation in the development of atherosclerosis.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Reumatologi och inflammation (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Rheumatology and Autoimmunity (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Kardiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cardiac and Cardiovascular Systems (hsv//eng)
Keyword
- Cardiovascular disease (CVD)
- Carotid intima-media thickness (cIMT)
- Radiographic axial spondyloarthritis (r-axSpA)
- Ultrasound
- Cardiovascular disease (CVD)
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Law, Lucy
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Lindqvist, Per
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Liv, Per, 1979-
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Hellman, Urban, ...
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Lejon, Kristina, ...
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Geijer, Mats, 19 ...
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Söderberg, Stefa ...
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Forsblad d'Elia, ...
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Rheumatology and ...
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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- Articles in the publication
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CLINICAL RHEUMAT ...
- By the university
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University of Gothenburg
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Umeå University
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Lund University