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WFRF:(Horwitz M)
 

Sökning: WFRF:(Horwitz M) > (2010-2014) > Long-Term Survival ...

LIBRIS Formathandbok  (Information om MARC21)
FältnamnIndikatorerMetadata
00003430naa a2200469 4500
001oai:gup.ub.gu.se/160396
003SwePub
008240528s2012 | |||||||||||000 ||eng|
0247 a https://gup.ub.gu.se/publication/1603962 URI
040 a (SwePub)gu
041 a eng
042 9 SwePub
072 7a ref2 swepub-contenttype
072 7a art2 swepub-publicationtype
1001 a Eapen, Mary4 aut
2451 0a Long-Term Survival and Late Deaths after Hematopoietic Cell Transplantation for Primary Immunodeficiency Diseases and Inborn Errors of Metabolism.
264 1c 2012
520 a It is uncertain whether late mortality rates after hematopoietic cell transplantation for severe combined immunodeficiency (SCID), non-SCID primary immunodeficiency diseases (non-SCID PIDD), and inborn errors of metabolism (IEM) return to rates observed in the general population, matched for age, sex, and nationality. We studied patients with SCID (n = 201), non-SCID PIDD (n = 405), and IEM (n = 348) who survived for at least 2 years after transplantation with normal T cell function (SCID) or >95% donor chimerism (non-SCID PIDD and IEM). Importantly, mortality rate was significantly higher in these patients compared with the general population for several years after transplantation. The rate decreased toward the normal rate in patients with SCID and non-SCID PIDD beyond 6 years after transplantation, but not in patients with IEM. Active chronic graft-versus-host disease at 2 years was associated with increased risk of late mortality for all diseases (hazard ratio [HR], 1.87; P = .05). In addition, late mortality was higher in patients with non-SCID PIDD who received T cell-depleted grafts (HR 4.16; P = .007) and in patients with IEM who received unrelated donor grafts (HR, 2.72; P = .03) or mismatched related donor grafts (HR, 3.76; P = .01). The finding of higher mortality rates in these long-term survivors for many years after transplantation confirms the need for long-term surveillance.
650 7a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Pediatrik0 (SwePub)302212 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Pediatrics0 (SwePub)302212 hsv//eng
7001 a Ahn, Kwang Woo4 aut
7001 a Orchard, Paul J4 aut
7001 a Cowan, Morton J4 aut
7001 a Davies, Stella M4 aut
7001 a Fasth, Anders,d 1945u Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper, Avdelningen för pediatrik,Institute of Clinical Sciences, Department of Pediatrics4 aut0 (Swepub:gu)xfasan
7001 a Hassebroek, Anna4 aut
7001 a Ayas, Mouhab4 aut
7001 a Bonfim, Carmem4 aut
7001 a O'Brien, Tracey A4 aut
7001 a Gross, Thomas G4 aut
7001 a Horwitz, Mitchell4 aut
7001 a Horwitz, Edwin4 aut
7001 a Kapoor, Neena4 aut
7001 a Kurtzberg, Joanne4 aut
7001 a Majhail, Navneet4 aut
7001 a Ringden, Olle4 aut
7001 a Szabolcs, Paul4 aut
7001 a Veys, Paul4 aut
7001 a Scott Baker, K4 aut
7102 a Göteborgs universitetb Institutionen för kliniska vetenskaper, Avdelningen för pediatrik4 org
7730 t Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantationg 18:9, s. 1438-1445q 18:9<1438-1445x 1523-6536
8564 8u https://gup.ub.gu.se/publication/160396

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