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  • Marcotte, HaroldKarolinska Institutet (author)

Immunity to SARS-CoV-2 up to 15 months after infection

  • Article/chapterEnglish2022

Publisher, publication year, extent ...

  • Elsevier BV,2022
  • printrdacarrier

Numbers

  • LIBRIS-ID:oai:DiVA.org:su-203218
  • https://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-203218URI
  • https://doi.org/10.1016/j.isci.2022.103743DOI
  • http://kipublications.ki.se/Default.aspx?queryparsed=id:148957173URI

Supplementary language notes

  • Language:English
  • Summary in:English

Part of subdatabase

Classification

  • Subject category:ref swepub-contenttype
  • Subject category:art swepub-publicationtype

Notes

  • Information concerning the longevity of immunity to SARS-CoV-2 following natural infection may have considerable implications for durability of immunity induced by vaccines. Here, we monitored the SARS-CoV-2 specific immune response in COVID-19 patients followed up to 15 months after symptoms onset. Following a peak at day 15-28 postinfection, the IgG antibody response and plasma neutralizing titers gradually decreased over time but stabilized after 6 months. Compared to G614, plasma neutralizing titers were more than 8-fold lower against variants Beta, Gamma, and Delta. SARS-CoV-2-specific memory B and T cells persisted in the majority of patients up to 15 months although a significant decrease in specific T cells, but not B cells, was observed between 6 and 15 months. Antiviral specific immunity, especially memory B cells in COVID-19 convalescent patients, is long-lasting, but some variants of concern may at least partially escape the neutralizing activity of plasma antibodies.

Subject headings and genre

Added entries (persons, corporate bodies, meetings, titles ...)

  • Piralla, Antonio (author)
  • Zuo, FangleiKarolinska Institutet (author)
  • Du, LikunKarolinska Institutet (author)
  • Cassaniti, Irene (author)
  • Wan, HuiKarolinska Institutet (author)
  • Kumagai-Braesh, MakikoKarolinska Institutet (author)
  • Andréll, JuniStockholms universitet,Science for Life Laboratory (SciLifeLab),Institutionen för biokemi och biofysik(Swepub:su)juand (author)
  • Percivalle, Elena (author)
  • Sammartino, Josè Camilla (author)
  • Wang, YatingKarolinska Institutet (author)
  • Vlachiotis, SteliosKarolinska Institutet (author)
  • Attevall, Janine (author)
  • Bergami, Federica (author)
  • Ferrari, Alessandro (author)
  • Colaneri, Marta (author)
  • Vecchia, Marco (author)
  • Sambo, Margherita (author)
  • Zuccaro, Valentina (author)
  • Asperges, Erika (author)
  • Bruno, Raffaele (author)
  • Oggionni, Tiberio (author)
  • Meloni, Federica (author)
  • Abolhassani, HassanKarolinska Institutet (author)
  • Bertoglio, Federico (author)
  • Schubert, Maren (author)
  • Calzolai, Luigi (author)
  • Varani, Luca (author)
  • Hust, Michael (author)
  • Xue, Yintong (author)
  • Hammarström, LennartKarolinska Institutet (author)
  • Baldanti, Fausto (author)
  • Pan-Hammarström, QiangKarolinska Institutet (author)
  • Karolinska InstitutetScience for Life Laboratory (SciLifeLab) (creator_code:org_t)

Related titles

  • In:iScience: Elsevier BV25:22589-0042

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