WFRF:(Idevall Hagren Olof 1980 )
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Keeping pace : the primary cilium as the conducting baton of the islet
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- Idevall Hagren, Olof, 1980- (author)
- Uppsala universitet,Institutionen för medicinsk cellbiologi
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- Incedal Nilsson, Ceren (author)
- Uppsala universitet,Institutionen för medicinsk cellbiologi
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- Sanchez, Gonzalo (author)
- Uppsala universitet,Institutionen för medicinsk cellbiologi
- (creator_code:org_t)
- Springer, 2024
- 2024
- English.
- In: Diabetologia. - : Springer. - 0012-186X .- 1432-0428. ; 67, s. 773-782
- Research review (peer-reviewed)
Abstract
Subject headings
Close
- Primary cilia are rod-like sensory organelles that protrude from the surface of most mammalian cells, including the cells of the islet, and mounting evidence supports important roles of these structures in the regulation of beta cell function and insulin secretion. The sensory abilities of the cilium arise from local receptor activation that is coupled to intrinsic signal transduction, and ciliary signals can propagate into the cell and influence cell function. Here, we review recent advances and studies that provide insights into intra-islet cues that trigger primary cilia signalling; how second messenger signals are generated and propagated within cilia; and how ciliary signalling affects beta cell function. We also discuss the potential involvement of primary cilia and ciliary signalling in the development and progression of type 2 diabetes, identify gaps in our current understanding of islet cell cilia function and provide suggestions on how to further our understanding of this intriguing structure.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Cell- och molekylärbiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Cell and Molecular Biology (hsv//eng)
- NATURVETENSKAP -- Biologi -- Cellbiologi (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences -- Cell Biology (hsv//eng)
Keyword
- Beta cell
- Ca2
- cAMP
- G protein-coupled receptor
- Hedgehog
- Primary cilium
- Somatostatin
- Type 2 diabetes
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