CCL2 mediates anti-fibrotic effects in human fibroblasts independently of CCR2

QC 20140624
CCL2 is known for its major role as a chemoattractant of monocytes for immunological surveillance and to site of inflammation. CCL2 acts mainly through the G-protein-coupled receptor CCR2 but has also been described to mediate its effects independently of this receptor in vitro and in vivo. Emerging pieces of evidence indicate that the CCL2/CCR2 axis is involved in fibrotic diseases, such as increased plasma levels of CCL2 and the presence of CCL2-hyperresponsive fibroblasts explanted from patients with systemic sclerosis and idiopathic pulmonary fibrosis. One of the profibrotic key mediators is the myofibroblast characterized by overexpression of alpha-smooth muscle actin and collagen I. However, the correlation between the CCL2/CCR2 axis and the activation of fibroblasts is not yet fully understood. We have screened human fibroblasts of various origins, human pulmonary fibroblasts (HPF), human fetal lung fibroblasts (HFL-1) and primary preadipocytes (SPF-1) in regard to CCL2 stimulated fibrotic responses. Surprisingly we found that CCL2 mediates anti-fibrotic effects independently of CCR2 in human fibroblasts of different origins.

Stadler, CharlotteKTH,Proteomik och nanobioteknologi,Science for Life Laboratory, SciLifeLab(Swepub:kth)u1r100ik (författare)
Forsgren, Margareta (författare)
Kvastad, LindaKTH,Genteknologi,Science for Life Laboratory, SciLifeLab(Swepub:kth)u1fok912 (författare)
Johansson, ElinKTH,Genteknologi,Science for Life Laboratory, SciLifeLab(Swepub:kth)u151qhvp (författare)
Sydow-Bäckman, Mona (författare)
Gelius, Stefan Svensson (författare)
Karolinska InstitutetProteomik och nanobioteknologi (creator_code:org_t)

Ingår i:International Immunopharmacology: Elsevier BV20:1, s. 66-731567-57691878-1705

Av författaren/redakt...: Kalderén, Christ ...; Stadler, Charlot ...; Forsgren, Margar ...; Kvastad, Linda; Johansson, Elin; Sydow-Bäckman, M ...; visa fler...; Gelius, Stefan S ...; visa färre...

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