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Protocol for an ind...
Protocol for an individual patient data meta-analysis on blood pressure targets after cardiac arrest
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- Skrifvars, Markus B. (author)
- Helsinki University Central Hospital
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- Ameloot, Koen (author)
- University Hospitals Leuven,Hospital Oost-Limburg,Hasselt University
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- Grand, Johannes (author)
- Copenhagen University Hospital
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- Reinikainen, Matti (author)
- University of Eastern Finland
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- Hästbacka, Johanna (author)
- Helsinki University Central Hospital
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- Niemelä, Ville (author)
- Helsinki University Central Hospital
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- Hassager, Christian (author)
- Copenhagen University Hospital
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- Kjaergaard, Jesper (author)
- Copenhagen University Hospital
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- Åneman, Anders (author)
- South Western Sydney Local Health District,Macquarie University, Sydney,University of New South Wales
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- Tiainen, Marjaana (author)
- Helsinki University Central Hospital
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- Nielsen, Niklas (author)
- Lund University,Lunds universitet,Anestesiologi och intensivvård,Sektion II,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Kliniska Vetenskaper, Helsingborg,Institutionen för kliniska vetenskaper, Lund,Centrum för hjärtstopp,Forskargrupper vid Lunds universitet,Anesthesiology and Intensive Care,Section II,Department of Clinical Sciences, Lund,Faculty of Medicine,Clinical Sciences, Helsingborg,Department of Clinical Sciences, Lund,Center for cardiac arrest,Lund University Research Groups,Helsingborg Hospital
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- Ullen, Susann (author)
- Clinical Studies Sweden-Forum South,Skåne University Hospital
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- Dankiewicz, Josef (author)
- Lund University,Lunds universitet,Kardiologi,Sektion II,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Cardiology,Section II,Department of Clinical Sciences, Lund,Faculty of Medicine,Skåne University Hospital
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- Olsen, Markus Harboe (author)
- Copenhagen University Hospital
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- Jørgensen, Caroline Kamp (author)
- Copenhagen University Hospital
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- Saxena, Manoj (author)
- University of New South Wales
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- Jakobsen, Janus C. (author)
- University of Southern Denmark,Copenhagen University Hospital
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(creator_code:org_t)
- 2022-06-09
- 2022
- English.
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In: Acta Anaesthesiologica Scandinavica. - : Wiley. - 0001-5172 .- 1399-6576. ; 66:7, s. 890-897
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http://dx.doi.org/10... (free)
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Abstract
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- Background: Hypotension is common after cardiac arrest (CA), and current guidelines recommend using vasopressors to target mean arterial blood pressure (MAP) higher than 65 mmHg. Pilot trials have compared higher and lower MAP targets. We will review the evidence on whether higher MAP improves outcome after cardiac arrest. Methods: This systematic review and meta-analysis will be conducted based on a systematic search of relevant major medical databases from their inception onwards, including MEDLINE, Embase and the Cochrane Central Register of Controlled Trials (CENTRAL), as well as clinical trial registries. We will identify randomised controlled trials published in the English language that compare targeting a MAP higher than 65–70 mmHg in CA patients using vasopressors, inotropes and intravenous fluids. The data extraction will be performed separately by two authors (a third author will be involved in case of disagreement), followed by a bias assessment with the Cochrane Risk of Bias tool using an eight-step procedure for assessing if thresholds for clinical significance are crossed. The outcomes will be all-cause mortality, functional long-term outcomes and serious adverse events. We will contact the authors of the identified trials to request individual anonymised patient data to enable individual patient data meta-analysis, aggregate data meta-analyses, trial sequential analyses and multivariable regression, controlling for baseline characteristics. The certainty of the evidence will be assessed by the Grading of Recommendations, Assessment, Development and Evaluation (GRADE) system. We will register this systematic review with Prospero and aim to redo it when larger trials are published in the near future. Conclusions: This protocol defines the performance of a systematic review on whether a higher MAP after cardiac arrest improves patient outcome. Repeating this systematic review including more data likely will allow for more certainty regarding the effect of the intervention and possible sub-groups differences.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Anestesi och intensivvård (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Anesthesiology and Intensive Care (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Kardiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cardiac and Cardiovascular Systems (hsv//eng)
Keyword
- cardiac arrest
- cardiopulmonary resuscitation
- mean arterial blood pressure
Publication and Content Type
- art (subject category)
- ref (subject category)
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Skrifvars, Marku ...
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Ameloot, Koen
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Grand, Johannes
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Reinikainen, Mat ...
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Hästbacka, Johan ...
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Niemelä, Ville
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Hassager, Christ ...
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Kjaergaard, Jesp ...
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Åneman, Anders
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Tiainen, Marjaan ...
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Nielsen, Niklas
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Ullen, Susann
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Dankiewicz, Jose ...
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Olsen, Markus Ha ...
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Jørgensen, Carol ...
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Saxena, Manoj
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Jakobsen, Janus ...
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- MEDICAL AND HEALTH SCIENCES
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and Anesthesiology a ...
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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Acta Anaesthesio ...
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Lund University