Sökning: WFRF:(Karlsson Johan 1984) > The effect of alend...
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000 | 04253naa a2200493 4500 | |
001 | oai:DiVA.org:uu-277970 | |
003 | SwePub | |
008 | 160223s2016 | |||||||||||000 ||eng| | |
009 | oai:research.chalmers.se:c519a19c-00f7-49a6-83ed-d36127ea1fb5 | |
024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-2779702 URI |
024 | 7 | a https://doi.org/10.1002/jbm.a.356022 DOI |
024 | 7 | a https://research.chalmers.se/publication/2300782 URI |
040 | a (SwePub)uud (SwePub)cth | |
041 | a engb eng | |
042 | 9 SwePub | |
072 | 7 | a ref2 swepub-contenttype |
072 | 7 | a art2 swepub-publicationtype |
100 | 1 | a Karlsson, Johan,d 1984u Chalmers, Dept Chem & Chem Engn, S-41296 Gothenburg, Sweden.,Chalmers tekniska högskola,Chalmers University of Technology4 aut0 (Swepub:cth)karjoha |
245 | 1 0 | a The effect of alendronate on biomineralization at the bone/implant interface |
264 | c 2015-11-12 | |
264 | 1 | b Wiley,c 2016 |
338 | a print2 rdacarrier | |
520 | a A recent approach to improve the osseointegration of implants is to utilize local drug administration. The presence of an osteoporosis drug may influence both bone quantity and quality at the bone/implant interface. Despite this, the performance of bone-anchoring implants is traditionally evaluated only by quantitative measurements. In the present study, the osteoporosis drug alendronate (ALN) was administrated from mesoporous titania thin films that were coated onto titanium implants. The effect that the drug had on biomineralization was explored both in vitro using simulated body fluid (SBF) and in vivo in a rat tibia model. The SBF study showed that the apatite formation was completely hindered at a high concentration of ALN (0.1 mg/mL). However, when ALN was administrated from the mesoporous coating the surface became completely covered with apatite. Ex vivo characterization of the bone/implant interface using Raman spectroscopy demonstrated that the presence of ALN enhanced the bone mineralization, and that the chemical signature of newly formed bone in the presence of ALN had a higher resemblance to the pre-existing mature bone than to the bone formed without drug. Taken together, this study demonstrates the importance of evaluating the quality of the formed bone to better understand the performance of implants. | |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Medicinsk bioteknologix Medicinsk bioteknologi0 (SwePub)304012 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Medical Biotechnologyx Medical Biotechnology0 (SwePub)304012 hsv//eng |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Medicinsk bioteknologix Biomaterialvetenskap0 (SwePub)304032 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Medical Biotechnologyx Biomaterials Science0 (SwePub)304032 hsv//eng |
650 | 7 | a NATURVETENSKAPx Kemi0 (SwePub)1042 hsv//swe |
650 | 7 | a NATURAL SCIENCESx Chemical Sciences0 (SwePub)1042 hsv//eng |
653 | a implants | |
653 | a mesoporous materials | |
653 | a bone mineralization | |
653 | a in vivo | |
653 | a Raman spectroscopy | |
700 | 1 | a Martinelli, Anna,d 1978u Chalmers, Dept Chem & Chem Engn, S-41296 Gothenburg, Sweden.,Chalmers tekniska högskola,Chalmers University of Technology4 aut0 (Swepub:cth)annamart |
700 | 1 | a Mashadi Fathali, Hoda,d 1983u Chalmers, Dept Chem & Chem Engn, S-41296 Gothenburg, Sweden.,Chalmers tekniska högskola,Chalmers University of Technology4 aut0 (Swepub:cth)mashadi |
700 | 1 | a Bielecki, Johanu Uppsala universitet,Molekylär biofysik,Uppsala University4 aut0 (Swepub:cth)bieljoha |
700 | 1 | a Andersson, Martin,d 1974u Chalmers, Dept Chem & Chem Engn, S-41296 Gothenburg, Sweden.,Chalmers tekniska högskola,Chalmers University of Technology4 aut0 (Swepub:cth)martina |
710 | 2 | a Chalmers, Dept Chem & Chem Engn, S-41296 Gothenburg, Sweden.b Chalmers tekniska högskola4 org |
773 | 0 | t Journal of Biomedical Materials Research. Part Ad : Wileyg 104:3, s. 620-629q 104:3<620-629x 1549-3296x 1552-4965 |
856 | 4 | u http://dx.doi.org/10.1002/jbm.a.35602y FULLTEXT |
856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-277970 |
856 | 4 8 | u https://doi.org/10.1002/jbm.a.35602 |
856 | 4 8 | u https://research.chalmers.se/publication/230078 |
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