The effect of alendronate on biomineralization at the bone/implant interface

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Fältnamn	Indikatorer	Metadata
000		04253naa a2200493 4500
001		oai:DiVA.org:uu-277970
003		SwePub
008		160223s2016 \| \|\|\|\|\|\|\|\|\|\|\|000 \|\|eng\|
009		oai:research.chalmers.se:c519a19c-00f7-49a6-83ed-d36127ea1fb5
024	7	a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-2779702 URI
024	7	a https://doi.org/10.1002/jbm.a.356022 DOI
024	7	a https://research.chalmers.se/publication/2300782 URI
040		a (SwePub)uud (SwePub)cth
041		a engb eng
042		9 SwePub
072	7	a ref2 swepub-contenttype
072	7	a art2 swepub-publicationtype
100	1	a Karlsson, Johan,d 1984u Chalmers, Dept Chem & Chem Engn, S-41296 Gothenburg, Sweden.,Chalmers tekniska högskola,Chalmers University of Technology4 aut0 (Swepub:cth)karjoha
245	1 0	a The effect of alendronate on biomineralization at the bone/implant interface
264		c 2015-11-12
264	1	b Wiley,c 2016
338		a print2 rdacarrier
520		a A recent approach to improve the osseointegration of implants is to utilize local drug administration. The presence of an osteoporosis drug may influence both bone quantity and quality at the bone/implant interface. Despite this, the performance of bone-anchoring implants is traditionally evaluated only by quantitative measurements. In the present study, the osteoporosis drug alendronate (ALN) was administrated from mesoporous titania thin films that were coated onto titanium implants. The effect that the drug had on biomineralization was explored both in vitro using simulated body fluid (SBF) and in vivo in a rat tibia model. The SBF study showed that the apatite formation was completely hindered at a high concentration of ALN (0.1 mg/mL). However, when ALN was administrated from the mesoporous coating the surface became completely covered with apatite. Ex vivo characterization of the bone/implant interface using Raman spectroscopy demonstrated that the presence of ALN enhanced the bone mineralization, and that the chemical signature of newly formed bone in the presence of ALN had a higher resemblance to the pre-existing mature bone than to the bone formed without drug. Taken together, this study demonstrates the importance of evaluating the quality of the formed bone to better understand the performance of implants.
650	7	a MEDICIN OCH HÄLSOVETENSKAPx Medicinsk bioteknologix Medicinsk bioteknologi0 (SwePub)304012 hsv//swe
650	7	a MEDICAL AND HEALTH SCIENCESx Medical Biotechnologyx Medical Biotechnology0 (SwePub)304012 hsv//eng
650	7	a MEDICIN OCH HÄLSOVETENSKAPx Medicinsk bioteknologix Biomaterialvetenskap0 (SwePub)304032 hsv//swe
650	7	a MEDICAL AND HEALTH SCIENCESx Medical Biotechnologyx Biomaterials Science0 (SwePub)304032 hsv//eng
650	7	a NATURVETENSKAPx Kemi0 (SwePub)1042 hsv//swe
650	7	a NATURAL SCIENCESx Chemical Sciences0 (SwePub)1042 hsv//eng
653		a implants
653		a mesoporous materials
653		a bone mineralization
653		a in vivo
653		a Raman spectroscopy
700	1	a Martinelli, Anna,d 1978u Chalmers, Dept Chem & Chem Engn, S-41296 Gothenburg, Sweden.,Chalmers tekniska högskola,Chalmers University of Technology4 aut0 (Swepub:cth)annamart
700	1	a Mashadi Fathali, Hoda,d 1983u Chalmers, Dept Chem & Chem Engn, S-41296 Gothenburg, Sweden.,Chalmers tekniska högskola,Chalmers University of Technology4 aut0 (Swepub:cth)mashadi
700	1	a Bielecki, Johanu Uppsala universitet,Molekylär biofysik,Uppsala University4 aut0 (Swepub:cth)bieljoha
700	1	a Andersson, Martin,d 1974u Chalmers, Dept Chem & Chem Engn, S-41296 Gothenburg, Sweden.,Chalmers tekniska högskola,Chalmers University of Technology4 aut0 (Swepub:cth)martina
710	2	a Chalmers, Dept Chem & Chem Engn, S-41296 Gothenburg, Sweden.b Chalmers tekniska högskola4 org
773	0	t Journal of Biomedical Materials Research. Part Ad : Wileyg 104:3, s. 620-629q 104:3<620-629x 1549-3296x 1552-4965
856	4	u http://dx.doi.org/10.1002/jbm.a.35602y FULLTEXT
856	4 8	u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-277970
856	4 8	u https://doi.org/10.1002/jbm.a.35602
856	4 8	u https://research.chalmers.se/publication/230078

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