A transcriptome-wide association study of 229,000 women identifies new candidate susceptibility genes for breast cancer.

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Wu, LangVanderbilt University (author)

A transcriptome-wide association study of 229,000 women identifies new candidate susceptibility genes for breast cancer.

Article/chapterEnglish2018

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2018-06-18
Springer Science and Business Media LLC,2018
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LIBRIS-ID:oai:DiVA.org:uu-368169
https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-368169URI
https://doi.org/10.1038/s41588-018-0132-xDOI
http://kipublications.ki.se/Default.aspx?queryparsed=id:138685389URI
https://lup.lub.lu.se/record/09fa405b-2621-4c16-bf29-0da6ec4158b3URI

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Language:English
Summary in:English

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Subject category:ref swepub-contenttype
Subject category:art swepub-publicationtype

Notes

, including 14 genes at loci not yet reported for breast cancer. We silenced 13 genes and showed an effect for 11 on cell proliferation and/or colony-forming efficiency. Our study provides new insights into breast cancer genetics and biology.

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Shi, WeiQIMR Berghofer Medical Research Institute (author)
Long, JirongVanderbilt University (author)
Guo, XingyiVanderbilt University (author)
Michailidou, KyriakiCyprus Institute of Neurology and Genetics,University of Cambridge (author)
Beesley, JonathanQIMR Berghofer Medical Research Institute (author)
Bolla, Manjeet KUniversity of Cambridge (author)
Shu, Xiao-OuVanderbilt University (author)
Lu, YingchangVanderbilt University (author)
Cai, QiuyinVanderbilt University (author)
Al-Ejeh, FaresQIMR Berghofer Medical Research Institute (author)
Rozali, EsdyQIMR Berghofer Medical Research Institute (author)
Wang, QinUniversity of Cambridge (author)
Dennis, JoeUniversity of Cambridge (author)
Li, BingshanVanderbilt University (author)
Zeng, ChenjieVanderbilt University (author)
Feng, HelianHarvard University (author)
Gusev, AlexanderBrigham and Women's Hospital / Harvard Medical School,Harvard Medical School,Dana-Farber Cancer Institute (author)
Barfield, Richard THarvard University (author)
Andrulis, Irene LMount Sinai Hospital of University of Toronto,University of Toronto (author)
Anton-Culver, HodaUniversity of California, Irvine (author)
Arndt, VolkerGerman Cancer Research Centre (author)
Aronson, Kristan JQueen's University at Kingston (author)
Auer, Paul LFred Hutchinson Cancer Research Center,University of Wisconsin-Milwaukee (author)
Barrdahl, MyrtoGerman Cancer Research Centre (author)
Baynes, CarolineUniversity of Cambridge (author)
Beckmann, Matthias WUniversity Hospital Erlangen (author)
Benitez, JavierSpanish National Cancer Research Center (CNIO) (author)
Bermisheva, MarinaInstitute of Biochemistry and Genetics, Ufa Scientific Center RAS,Hannover Medical School (author)
Blomqvist, CarlÖrebro University,Helsinki University Central Hospital (author)
Bogdanova, Natalia VN.N. Alexandrov Research Institute of Oncology and Medical Radiology,Hannover Medical School (author)
Bojesen, Stig EGentofte Hospital,University of Copenhagen (author)
Brauch, HiltrudGerman Cancer Research Centre,University of Tübingen (author)
Brenner, HermannGerman Cancer Research Centre (author)
Brinton, LouiseNational Cancer Institute, USA (author)
Broberg, PerLund University,Lunds universitet,Medicinsk onkologi,Sektion I,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Medical oncology,Section I,Department of Clinical Sciences, Lund,Faculty of Medicine(Swepub:lu)med-pbo (author)
Brucker, Sara YUniversity of Tübingen (author)
Burwinkel, BarbaraGerman Cancer Research Centre,Heidelberg University (author)
Caldés, TrinidadHospital Clinico San Carlos de Madrid (author)
Canzian, FedericoGerman Cancer Research Centre (author)
Carter, Brian DAmerican Cancer Society (author)
Castelao, J EstebanXerencia de Xestion Integrada de Vigo-SERGAS (author)
Chang-Claude, JennyUniversity Medical Center Hamburg-Eppendorf,German Cancer Research Centre (author)
Chen, XiaoqingQIMR Berghofer Medical Research Institute (author)
Cheng, Ting-Yuan DavidFlorida Museum Natural History (author)
Christiansen, HansHannover Medical School (author)
Clarke, Christine LUniversity of Sydney (author)
Collée, MargrietErasmus University Medical Center (author)
Cornelissen, Sten (author)
Couch, Fergus J (author)
Cox, David (author)
Cox, Angela (author)
Cross, Simon S (author)
Cunningham, Julie M (author)
Czene, KamilaKarolinska Institutet (author)
Daly, Mary B (author)
Devilee, Peter (author)
Doheny, Kimberly F (author)
Dörk, Thilo (author)
Dos-Santos-Silva, Isabel (author)
Dumont, Martine (author)
Dwek, Miriam (author)
Eccles, Diana M (author)
Eilber, Ursula (author)
Eliassen, A Heather (author)
Engel, Christoph (author)
Eriksson, MikaelKarolinska Institutet (author)
Fachal, Laura (author)
Fasching, Peter A (author)
Figueroa, Jonine (author)
Flesch-Janys, Dieter (author)
Fletcher, Olivia (author)
Flyger, Henrik (author)
Fritschi, Lin (author)
Gabrielson, MarikeKarolinska Institutet (author)
Gago-Dominguez, Manuela (author)
Gapstur, Susan MKarolinska Institutet (author)
García-Closas, Montserrat (author)
Gaudet, Mia M (author)
Ghoussaini, Maya (author)
Giles, Graham G (author)
Goldberg, Mark S (author)
Goldgar, David E (author)
González-Neira, Anna (author)
Guénel, Pascal (author)
Hahnen, Eric (author)
Haiman, Christopher A (author)
Håkansson, NiclasKarolinska Institutet (author)
Hall, PerKarolinska Institutet (author)
Hallberg, Emily (author)
Hamann, Ute (author)
Harrington, Patricia (author)
Hein, Alexander (author)
Hicks, Belynda (author)
Hillemanns, Peter (author)
Hollestelle, Antoinette (author)
Hoover, Robert N (author)
Hopper, John L (author)
Huang, Guanmengqian (author)
Humphreys, KeithKarolinska Institute,Karolinska Institutet(Swepub:lu)med-khu (author)
Hunter, David J (author)
Jakubowska, Anna (author)
Janni, Wolfgang (author)
John, Esther M (author)
Johnson, Nichola (author)
Jones, Kristine (author)
Jones, Michael E (author)
Jung, Audrey (author)
Kaaks, Rudolf (author)
Kerin, Michael J (author)
Khusnutdinova, Elza (author)
Kosma, Veli-Matti (author)
Kristensen, Vessela N (author)
Lambrechts, Diether (author)
Le Marchand, Loic (author)
Li, Jingmei (author)
Lindström, Sara (author)
Lissowska, Jolanta (author)
Lo, Wing-Yee (author)
Loibl, Sibylle (author)
Lubinski, Jan (author)
Luccarini, Craig (author)
Lux, Michael P (author)
MacInnis, Robert J (author)
Maishman, Tom (author)
Kostovska, Ivana Maleva (author)
Mannermaa, Arto (author)
Manson, JoAnn E (author)
Margolin, Sara (author)
Mavroudis, Dimitrios (author)
Meijers-Heijboer, Hanne (author)
Meindl, Alfons (author)
Menon, Usha (author)
Meyer, Jeffery (author)
Mulligan, Anna Marie (author)
Neuhausen, Susan L (author)
Nevanlinna, Heli (author)
Neven, Patrick (author)
Nielsen, Sune F (author)
Nordestgaard, Børge G (author)
Olopade, Olufunmilayo I (author)
Olson, Janet E (author)
Olsson, HåkanLund University,Lunds universitet,Medicinsk onkologi,Sektion I,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Medical oncology,Section I,Department of Clinical Sciences, Lund,Faculty of Medicine(Swepub:lu)onk-hol (author)
Peterlongo, Paolo (author)
Peto, Julian (author)
Plaseska-Karanfilska, Dijana (author)
Prentice, Ross (author)
Presneau, Nadege (author)
Pylkäs, Katri (author)
Rack, Brigitte (author)
Radice, Paolo (author)
Rahman, Nazneen (author)
Rennert, Gad (author)
Rennert, Hedy S (author)
Rhenius, Valerie (author)
Romero, Atocha (author)
Romm, Jane (author)
Rudolph, Anja (author)
Saloustros, Emmanouil (author)
Sandler, Dale P (author)
Sawyer, Elinor J (author)
Schmidt, Marjanka K (author)
Schmutzler, Rita K (author)
Schneeweiss, Andreas (author)
Scott, Rodney J (author)
Scott, Christopher G (author)
Seal, Sheila (author)
Shah, Mitul (author)
Shrubsole, Martha J (author)
Smeets, Ann (author)
Southey, Melissa C (author)
Spinelli, John J (author)
Stone, Jennifer (author)
Surowy, Harald (author)
Swerdlow, Anthony J (author)
Tamimi, Rulla M (author)
Tapper, William (author)
Taylor, Jack A (author)
Terry, Mary Beth (author)
Tessier, Daniel C (author)
Thomas, Abigail (author)
Thöne, Kathrin (author)
Tollenaar, Rob A E M (author)
Torres, Diana (author)
Truong, Thérèse (author)
Untch, Michael (author)
Vachon, Celine (author)
Van Den Berg, David (author)
Vincent, Daniel (author)
Waisfisz, Quinten (author)
Weinberg, Clarice R (author)
Wendt, Camilla (author)
Whittemore, Alice S (author)
Wildiers, Hans (author)
Willett, Walter C (author)
Winqvist, Robert (author)
Wolk, AlicjaKarolinska Institutet,Uppsala universitet,Ortopedi(Swepub:uu)alwol516 (author)
Xia, Lucy (author)
Yang, Xiaohong R (author)
Ziogas, Argyrios (author)
Ziv, Elad (author)
Dunning, Alison M (author)
Pharoah, Paul D P (author)
Simard, Jacques (author)
Milne, Roger L (author)
Edwards, Stacey L (author)
Kraft, Peter (author)
Easton, Douglas F (author)
Chenevix-Trench, Georgia (author)
Zheng, Wei (author)
Vanderbilt UniversityQIMR Berghofer Medical Research Institute (creator_code:org_t)

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In:Nature Genetics: Springer Science and Business Media LLC50:7, s. 968-9781061-40361546-1718

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By the author/editor: Wu, Lang; Shi, Wei; Long, Jirong; Guo, Xingyi; Michailidou, Kyr ...; Beesley, Jonatha ...; show more...; Bolla, Manjeet K; Shu, Xiao-Ou; Lu, Yingchang; Cai, Qiuyin; Al-Ejeh, Fares; Rozali, Esdy; Wang, Qin; Dennis, Joe; Li, Bingshan; Zeng, Chenjie; Feng, Helian; Gusev, Alexander; Barfield, Richar ...; Andrulis, Irene ...; Anton-Culver, Ho ...; Arndt, Volker; Aronson, Kristan ...; Auer, Paul L; Barrdahl, Myrto; Baynes, Caroline; Beckmann, Matthi ...; Benitez, Javier; Bermisheva, Mari ...; Blomqvist, Carl; Bogdanova, Natal ...; Bojesen, Stig E; Brauch, Hiltrud; Brenner, Hermann; Brinton, Louise; Broberg, Per; Brucker, Sara Y; Burwinkel, Barba ...; Caldés, Trinidad; Canzian, Federic ...; Carter, Brian D; Castelao, J Este ...; Chang-Claude, Je ...; Chen, Xiaoqing; Cheng, Ting-Yuan ...; Christiansen, Ha ...; Clarke, Christin ...; Collée, Margriet; Cornelissen, Ste ...; Couch, Fergus J; Cox, David; Cox, Angela; Cross, Simon S; Cunningham, Juli ...; Czene, Kamila; Daly, Mary B; Devilee, Peter; Doheny, Kimberly ...; Dörk, Thilo; Dos-Santos-Silva ...; Dumont, Martine; Dwek, Miriam; Eccles, Diana M; Eilber, Ursula; Eliassen, A Heat ...; Engel, Christoph; Eriksson, Mikael; Fachal, Laura; Fasching, Peter ...; Figueroa, Jonine; Flesch-Janys, Di ...; Fletcher, Olivia; Flyger, Henrik; Fritschi, Lin; Gabrielson, Mari ...; Gago-Dominguez, ...; Gapstur, Susan M; García-Closas, M ...; Gaudet, Mia M; Ghoussaini, Maya; Giles, Graham G; Goldberg, Mark S; Goldgar, David E; González-Neira, ...; Guénel, Pascal; Hahnen, Eric; Haiman, Christop ...; Håkansson, Nicla ...; Hall, Per; Hallberg, Emily; Hamann, Ute; Harrington, Patr ...; Hein, Alexander; Hicks, Belynda; Hillemanns, Pete ...; Hollestelle, Ant ...; Hoover, Robert N; Hopper, John L; Huang, Guanmengq ...; Humphreys, Keith; Hunter, David J; Jakubowska, Anna; Janni, Wolfgang; John, Esther M; Johnson, Nichola; Jones, Kristine; Jones, Michael E; Jung, Audrey; Kaaks, Rudolf; Kerin, Michael J; Khusnutdinova, E ...; Kosma, Veli-Matt ...; Kristensen, Vess ...; Lambrechts, Diet ...; Le Marchand, Loi ...; Li, Jingmei; Lindström, Sara; Lissowska, Jolan ...; Lo, Wing-Yee; Loibl, Sibylle; Lubinski, Jan; Luccarini, Craig; Lux, Michael P; MacInnis, Robert ...; Maishman, Tom; Kostovska, Ivana ...; Mannermaa, Arto; Manson, JoAnn E; Margolin, Sara; Mavroudis, Dimit ...; Meijers-Heijboer ...; Meindl, Alfons; Menon, Usha; Meyer, Jeffery; Mulligan, Anna M ...; Neuhausen, Susan ...; Nevanlinna, Heli; Neven, Patrick; Nielsen, Sune F; Nordestgaard, Bø ...; Olopade, Olufunm ...; Olson, Janet E; Olsson, Håkan; Peterlongo, Paol ...; Peto, Julian; Plaseska-Karanfi ...; Prentice, Ross; Presneau, Nadege; Pylkäs, Katri; Rack, Brigitte; Radice, Paolo; Rahman, Nazneen; Rennert, Gad; Rennert, Hedy S; Rhenius, Valerie; Romero, Atocha; Romm, Jane; Rudolph, Anja; Saloustros, Emma ...; Sandler, Dale P; Sawyer, Elinor J; Schmidt, Marjank ...; Schmutzler, Rita ...; Schneeweiss, And ...; Scott, Rodney J; Scott, Christoph ...; Seal, Sheila; Shah, Mitul; Shrubsole, Marth ...; Smeets, Ann; Southey, Melissa ...; Spinelli, John J; Stone, Jennifer; Surowy, Harald; Swerdlow, Anthon ...; Tamimi, Rulla M; Tapper, William; Taylor, Jack A; Terry, Mary Beth; Tessier, Daniel ...; Thomas, Abigail; Thöne, Kathrin; Tollenaar, Rob A ...; Torres, Diana; Truong, Thérèse; Untch, Michael; Vachon, Celine; Van Den Berg, Da ...; Vincent, Daniel; Waisfisz, Quinte ...; Weinberg, Claric ...; Wendt, Camilla; Whittemore, Alic ...; Wildiers, Hans; Willett, Walter ...; Winqvist, Robert; Wolk, Alicja; Xia, Lucy; Yang, Xiaohong R; Ziogas, Argyrios; Ziv, Elad; Dunning, Alison ...; Pharoah, Paul D ...; Simard, Jacques; Milne, Roger L; Edwards, Stacey ...; Kraft, Peter; Easton, Douglas ...; Chenevix-Trench, ...; Zheng, Wei; show less...

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