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Sökning: WFRF:(Klein Pontus) > Loss of SNAP-25 and...

LIBRIS Formathandbok  (Information om MARC21)
FältnamnIndikatorerMetadata
00003572naa a2200409 4500
001oai:lup.lub.lu.se:bcf36e82-5012-48ff-b8f2-c3def8bb5dcf
003SwePub
008160401s2007 | |||||||||||000 ||eng|
0247 a https://lup.lub.lu.se/record/6076932 URI
0247 a https://doi.org/10.1111/j.1471-4159.2007.04703.x2 DOI
040 a (SwePub)lu
041 a engb eng
042 9 SwePub
072 7a art2 swepub-publicationtype
072 7a ref2 swepub-contenttype
1001 a Smith, Rubenu Lund University,Lunds universitet,Institutionen för experimentell medicinsk vetenskap,Medicinska fakulteten,Department of Experimental Medical Science,Faculty of Medicine4 aut0 (Swepub:lu)mphy-rsm
2451 0a Loss of SNAP-25 and rabphilin 3a in sensory-motor cortex in Huntington's disease.
264 c 2007-06-30
264 1b Wiley,c 2007
338 a electronic2 rdacarrier
520 a Huntington’s disease (HD) is an autosomal dominant neurodegenerative disorder caused by a CAG-expansion in the gene encoding the protein huntingtin. The disease is characterized by progressive motor disturbances, cognitive defects, dementia, and weight loss. Using western blotting and immunohistochemistry we have assessed the expression levels and patterns of a number of proteins involved in neurotransmitter release in post-mortem frontal cortex samples from 10 HD cases with different disease grades. We report a loss of the soluble N-ethylmaleimide-sensitive factor attachment protein receptor (SNARE) protein, synaptosome-associated protein 25 (SNAP 25) in HD brains of grades I–IV. Moreover, in brains of grade III and IV we found a reduction in rabphilin 3a, a protein involved in vesicle docking and recycling. These losses appear to be specific and not due to a general loss of synapses in the HD cortex. Thus, levels of synaptobrevin II, syntaxin 1, rab3a or synaptophysin are unaltered in the same patient samples. SNAP 25 and rabphilin 3a are crucial for neurotransmitter release. Therefore, we suggest that a deficient pre-synaptic transmitter release may underlie some of the symptoms of HD.
650 7a MEDICIN OCH HÄLSOVETENSKAPx Medicinska och farmaceutiska grundvetenskaperx Neurovetenskaper0 (SwePub)301052 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Basic Medicinex Neurosciences0 (SwePub)301052 hsv//eng
7001 a Klein, Pontusu Lund University,Lunds universitet,Institutionen för experimentell medicinsk vetenskap,Medicinska fakulteten,Department of Experimental Medical Science,Faculty of Medicine4 aut0 (Swepub:lu)med-pke
7001 a Koc-Schmitz, Yeliz4 aut
7001 a Waldvogel, Henry J4 aut
7001 a Faull, Richard L M4 aut
7001 a Brundin, Patriku Lund University,Lunds universitet,Institutionen för experimentell medicinsk vetenskap,Medicinska fakulteten,Department of Experimental Medical Science,Faculty of Medicine4 aut0 (Swepub:lu)mphy-pbr
7001 a Plomann, Markus4 aut
7001 a Li, Jia-Yi4 aut
7102 a Institutionen för experimentell medicinsk vetenskapb Medicinska fakulteten4 org
7730 t Journal of Neurochemistryd : Wileyg 103:1, s. 115-123q 103:1<115-123x 1471-4159x 0022-3042
8564 u https://portal.research.lu.se/files/4560701/626129.pdfx primaryx freey FULLTEXT
8564 u http://dx.doi.org/10.1111/j.1471-4159.2007.04703.xy FULLTEXT
8564 u https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/j.1471-4159.2007.04703.x
8564 8u https://lup.lub.lu.se/record/607693
8564 8u https://doi.org/10.1111/j.1471-4159.2007.04703.x

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