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LIBRIS Formathandbok  (Information om MARC21)
FältnamnIndikatorerMetadata
00003393nam a2200445 4500
001oai:DiVA.org:kth-291752
003SwePub
008210318| | |||||||||||000 ||eng|
0247 a https://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-2917522 URI
040 a (SwePub)kth
041 a engb eng
042 9 SwePub
072 7a vet2 swepub-contenttype
072 7a ovr2 swepub-publicationtype
1001 a Carlberg, Konstantinu KTH,Genteknologi,Science for Life Laboratory, SciLifeLab4 aut0 (Swepub:kth)u15np845
2451 0a Integrated Single Cell and Spatial Transcriptomics Reveal Autoreactive Differentiated B Cells in Joints of Early Rheumatoid Arthritis
338 a print2 rdacarrier
500 a QC 20210322
520 a Rheumatoid Arthritis (RA) is a prevalent autoimmune disease characterized by inflammation of peripheral joints. Patients can be subdivided by the presence or absence of Rheumatoid Factor and anti-citrullinated protein antibodies (ACPA) in their circulation. Inflammation of the joint tissue is associated with infiltration of leukocytes from the blood, which can result in generation of lymphoid structures composed of B and T cells. Previous studies have shown that both memory B cells and antibody-secreting plasma cells populate the rheumatic joint tissue when captured from established and often long-standing disease. However, it has remained unclear, whether these cells are autoreactive and whether the associated lymphoid structures are present at the site of inflammation already at the time of diagnosis. Here, we used an integrated single cell and spatial transcriptomic approach to study B and plasma cells in synovial tissue of ACPA- and ACPA+ RA patients at this early time point. We found evidence for T cell help to B cells and presence of memory B and plasma cell pools in ACPA- as well as in ACPA+ RA. Our results demonstrated common supportive microenvironments in both patient subgroups, clonal relationships between the memory B and plasma cell pools and autoreactivity within the plasma cell compartment. These findings challenge our understanding of the dynamics of local adaptive immune responses in the RA joint of ACPA- and ACPA+ patients at the time of diagnosis, with direct implications for B and T cell targeting therapies for both patient subgroups. 
650 7a NATURVETENSKAPx Biologix Immunologi0 (SwePub)106052 hsv//swe
650 7a NATURAL SCIENCESx Biological Sciencesx Immunology0 (SwePub)106052 hsv//eng
653 a Bioteknologi
653 a Biotechnology
7001 a Hardt, Uta4 aut
7001 a af Klint, Erik4 aut
7001 a Sahlström, Peter4 aut
7001 a Larsson, Ludvigu KTH,Genteknologi,Science for Life Laboratory, SciLifeLab4 aut0 (Swepub:kth)u13lw4hm
7001 a van Vollenhoven, Annika4 aut
7001 a Hernandez Machado, Susana4 aut
7001 a Israelsson, Lena4 aut
7001 a Amara, Khaled4 aut
7001 a Chemin, Karine4 aut
7001 a Korotkova, Marina4 aut
7001 a Karlsson Hedestam, Gunilla4 aut
7001 a Catrina, Anca4 aut
7001 a Teichmann, Sarah4 aut
7001 a Ståhl, Patrik,c Dr.u KTH,Science for Life Laboratory, SciLifeLab,Genteknologi4 aut0 (Swepub:kth)u1rstx38
7001 a Malmström, Vivianne4 aut
7102 a KTHb Genteknologi4 org
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-291752

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