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| Fältnamn | Indikatorer | Metadata |
|---|---|---|
| 000 | 09658naa a2203001 4500 | |
| 001 | oai:prod.swepub.kib.ki.se:141080484 | |
| 003 | SwePub | |
| 008 | 240701s2019 | |||||||||||000 ||eng| | |
| 024 | 7 | a http://kipublications.ki.se/Default.aspx?queryparsed=id:1410804842 URI |
| 024 | 7 | a https://doi.org/10.1038/s41467-019-10461-02 DOI |
| 040 | a (SwePub)ki | |
| 041 | a engb eng | |
| 042 | 9 SwePub | |
| 072 | 7 | a ref2 swepub-contenttype |
| 072 | 7 | a art2 swepub-publicationtype |
| 100 | 1 | a Czamara, D4 aut |
| 245 | 1 0 | a Integrated analysis of environmental and genetic influences on cord blood DNA methylation in new-borns |
| 264 | c 2019-06-11 | |
| 264 | 1 | b Springer Science and Business Media LLC,c 2019 |
| 520 | a Epigenetic processes, including DNA methylation (DNAm), are among the mechanisms allowing integration of genetic and environmental factors to shape cellular function. While many studies have investigated either environmental or genetic contributions to DNAm, few have assessed their integrated effects. Here we examine the relative contributions of prenatal environmental factors and genotype on DNA methylation in neonatal blood at variably methylated regions (VMRs) in 4 independent cohorts (overall n = 2365). We use Akaike’s information criterion to test which factors best explain variability of methylation in the cohort-specific VMRs: several prenatal environmental factors (E), genotypes in cis (G), or their additive (G + E) or interaction (GxE) effects. Genetic and environmental factors in combination best explain DNAm at the majority of VMRs. The CpGs best explained by either G, G + E or GxE are functionally distinct. The enrichment of genetic variants from GxE models in GWAS for complex disorders supports their importance for disease risk. | |
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| 700 | 1 | a Viktorin, Au Karolinska Institutet4 aut |
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| 700 | 1 | a Lewis, G4 aut |
| 700 | 1 | a Li, QQS4 aut |
| 700 | 1 | a Lucae, S4 aut |
| 700 | 1 | a Madden, PAF4 aut |
| 700 | 1 | a Magnusson, PKu Karolinska Institutet4 aut |
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| 700 | 1 | a Mors, O4 aut |
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| 700 | 1 | a Muller-Myhsok, B4 aut |
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| 700 | 1 | a Nothen, MM4 aut |
| 700 | 1 | a O'Donovan, MC4 aut |
| 700 | 1 | a Paciga, SA4 aut |
| 700 | 1 | a Pedersen, NLu Karolinska Institutet4 aut |
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| 700 | 1 | a Sullivan, PF4 aut |
| 710 | 2 | a Karolinska Institutet4 org |
| 773 | 0 | t Nature communicationsd : Springer Science and Business Media LLCg 10:1, s. 2548-q 10:1<2548-x 2041-1723 |
| 856 | 4 | u https://www.nature.com/articles/s41467-019-10461-0.pdf |
| 856 | 4 8 | u http://kipublications.ki.se/Default.aspx?queryparsed=id:141080484 |
| 856 | 4 8 | u https://doi.org/10.1038/s41467-019-10461-0 |
Hitta mer i SwePub
- Av författaren/redakt...
- Czamara, D
- Eraslan, G
- Page, CM
- Lahti, J
- Lahti-Pulkkinen, ...
- Hamalainen, E
- visa fler...
- Kajantie, E
- Laivuori, H
- Villa, PM
- Reynolds, RM
- Nystad, W
- Haberg, SE
- London, SJ
- O'Donnell, KJ
- Garg, E
- Meaney, MJ
- Entringer, S
- Wadhwa, PD
- Buss, C
- Jones, MJ
- Lin, DTS
- MacIsaac, JL
- Kobor, MS
- Koen, N
- Zar, HJ
- Koenen, KC
- Dalvie, S
- Stein, DJ
- Kondofersky, I
- Muller, NS
- Theis, FJ
- Raikkonen, K
- Binder, EB
- Wray, NR
- Ripke, S
- Mattheisen, M
- Trzaskowski, M
- Byrne, EM
- Abdellaoui, A
- Adams, MJ
- Agerbo, E
- Air, TM
- Andlauer, TFM
- Bacanu, SA
- Baekvad-Hansen, ...
- Beekman, ATF
- Bigdeli, TB
- Blackwood, DHR
- Bryois, J
- Buttenschon, HN
- Bybjerg-Grauholm ...
- Cai, N
- Castelao, E
- Christensen, JH
- Clarke, TK
- Coleman, JR
- Colodro-Conde, L
- Couvy-Duchesne, ...
- Craddock, N
- Crawford, GE
- Davies, G
- Deary, IJ
- Degenhardt, F
- Derks, EM
- Direk, N
- Dolan, C
- Dunn, EC
- Eley, TC
- Escott-Price, V
- Kiadeh, FFH
- Finucane, HK
- Forstner, AJ
- Frank, J
- Gaspar, HA
- Gill, M
- Goes, FS
- Gordon, SD
- Grove, J
- Hall, LS
- Hansen, CS
- Hansen, TF
- Herms, S
- Hickie, IB
- Hoffmann, P
- Homuth, G
- Horn, C
- Hottenga, JJ
- Hougaard, DM
- Ising, M
- Jansen, R
- Jorgenson, E
- Knowles, JA
- Kohane, IS
- Kraft, J
- Kretzschmar, WW
- Krogh, J
- Kutalik, Z
- Li, YH
- Lind, PA
- MacIntyre, DJ
- MacKinnon, DF
- Maier, RM
- Maier, W
- Marchini, J
- Mbarek, H
- McGrath, P
- McGuffin, P
- Medland, SE
- Mehta, D
- Middeldorp, CM
- Mihailov, E
- Milaneschi, Y
- Milani, L
- Mondimore, FM
- Montgomery, GW
- Mostafavi, S
- Mullins, N
- Nauck, M
- Ng, B
- Nivard, MG
- Nyholt, DR
- O'Reilly, PF
- Oskarsson, H
- Owen, MJ
- Painter, JN
- Pedersen, CB
- Pedersen, MG
- Peterson, RE
- Pettersson, E
- Peyrot, WJ
- Pistis, G
- Posthuma, D
- Quiroz, JA
- Qvist, P
- Rice, JP
- Riley, BP
- Rivera, M
- Mirza, SS
- Schoevers, R
- Schulte, EC
- Shen, L
- Shi, JX
- Shyn, S
- Sigurdsson, E
- Sinnamon, GCB
- Smit, JH
- Smith, DJ
- Stefansson, H
- Steinberg, S
- Streit, F
- Strohmaier, J
- Tansey, KE
- Teismann, H
- Teumer, A
- Thompson, W
- Thomson, PA
- Thorgeirsson, TE
- Traylor, M
- Treutlein, J
- Trubetskoy, V
- Uitterlinden, AG
- Umbricht, D
- Van der Auwera, ...
- van Hemert, AM
- Viktorin, A
- Visscher, PM
- Wang, YP
- Webb, BT
- Weinsheimer, SM
- Wellmann, J
- Willemsen, G
- Witt, SH
- Wu, Y
- Xi, HLS
- Yang, J
- Zhang, FT
- Arolt, V
- Baune, BT
- Berger, K
- Boomsma, D
- Cichon, S
- Dannlowski, U
- de Geus, EJC
- DePaulo, JR
- Domenici, E
- Domschke, K
- Esko, T
- Grabe, HJ
- Hamilton, SP
- Hayward, C
- Heath, AC
- Kendler, KS
- Kloiber, S
- Lewis, G
- Li, QQS
- Lucae, S
- Madden, PAF
- Magnusson, PK
- Martin, NG
- McIntosh, AM
- Metspalu, A
- Mors, O
- Mortensen, PB
- Muller-Myhsok, B
- Nordentoft, M
- Nothen, MM
- O'Donovan, MC
- Paciga, SA
- Pedersen, NL
- Penninx, BWJH
- Perlis, RH
- Porteous, DJ
- Potash, JB
- Preisig, M
- Rietschel, M
- Schaefer, C
- Schulze, TG
- Smoller, JW
- Stefansson, K
- Tiemeier, H
- Uher, R
- Volzke, H
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- Werge, T
- Lewis, CM
- Levinson, DF
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