BDNF makes cultured dentate granule cells more resistant to hypoglycaemic damage

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Kokaia, ZLund University,Lunds universitet,Neurologi, Lund,Sektion IV,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Neural stamcellsbiologi och terapi,Forskargrupper vid Lunds universitet,Stem Cells & Restorative Neurology,Neurology, Lund,Section IV,Department of Clinical Sciences, Lund,Faculty of Medicine,Neural stem cell biology and therapy,Lund University Research Groups,Skåne University Hospital,Institutionen för kliniska vetenskaper, Lund,Department of Clinical Sciences, Lund (author)

The aim of this study was to explore whether brain-derived neurotrophic factor (BDNF) can improve neuronal survival in cell cultures of rat dentate gyrus subjected to a hypoglycaemic insult. Glucose deprivation for 15 h caused severe neuronal loss (about 70%). BDNF added either 24 h before or 4 h after onset of hypoglycaemia completely protected granule cells against this insult-induced damage. Nerve growth factor (NGF) had similar effects. These findings support the hypothesis that the rapid upregulation of BDNF mRNA in dentate granule cells after brief periods of hypoglycaemic coma and other insults is a local protective mechanism.

MEDICIN OCH HÄLSOVETENSKAP Medicinska och farmaceutiska grundvetenskaper Neurovetenskaper hsv//swe
MEDICAL AND HEALTH SCIENCES Basic Medicine Neurosciences hsv//eng
Animals
Brain-Derived Neurotrophic Factor
Cell Survival
Cells, Cultured
Culture Media
Glucose
Hippocampus
Hypoglycemia
Immunohistochemistry
Nerve Growth Factors
Nerve Tissue Proteins
Neurons
Rats
Rats, Sprague-Dawley
Journal Article
Research Support, Non-U.S. Gov't
Hypoglycaemia
Dentate gyrus
Neurotrophins
Neuronal protection
Brain insults

Othberg, ALund University,Lunds universitet,Neuronano Research Center (NRC),Forskargrupper vid Lunds universitet,Lund University Research Groups(Swepub:lu)med-as4 (author)
Kokaia, MLund University,Lunds universitet,Epilepsicentrum,Sektion IV,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Neurologi, Lund,Institutionen för kliniska vetenskaper, Lund,Epilepsy Center,Section IV,Department of Clinical Sciences, Lund,Faculty of Medicine,Neurology, Lund,Department of Clinical Sciences, Lund,Institutionen för kliniska vetenskaper, Lund,Department of Clinical Sciences, Lund(Swepub:lu)neur-mko (author)
Lindvall, OLund University,Lunds universitet,Neurologi, Lund,Sektion IV,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Neurogenes och Cellterapi,Forskargrupper vid Lunds universitet,Stem Cells & Restorative Neurology,Neurology, Lund,Section IV,Department of Clinical Sciences, Lund,Faculty of Medicine,Neurogenesis and cell therapy,Lund University Research Groups,Institutionen för kliniska vetenskaper, Lund,Department of Clinical Sciences, Lund(Swepub:lu)neur-oli (author)
SanMartin, AgnetaLund University,Lunds universitet,Neuronano Research Center (NRC),Forskargrupper vid Lunds universitet,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Lund University Research Groups,Department of Clinical Sciences, Lund,Faculty of Medicine(Swepub:lu)med-as4 (author)
Neurologi, LundSektion IV (creator_code:org_t)

In:NeuroReport: Ovid Technologies (Wolters Kluwer Health)5:10, s. 4-12410959-49651473-558X

By the author/editor: Kokaia, Z; Othberg, A; Kokaia, M; Lindvall, O; SanMartin, Agnet ...

About the subject

MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Basic Medicine; and Neurosciences

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