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Sökning: WFRF:(Koppelman Gerard H.) > (2020-2022) > A novel whole blood...

LIBRIS Formathandbok  (Information om MARC21)
FältnamnIndikatorerMetadata
00008797naa a2200805 4500
001oai:DiVA.org:uu-450774
003SwePub
008210823s2020 | |||||||||||000 ||eng|
009oai:prod.swepub.kib.ki.se:143511808
0247 a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-4507742 URI
0247 a https://doi.org/10.1111/all.143142 DOI
0247 a http://kipublications.ki.se/Default.aspx?queryparsed=id:1435118082 URI
040 a (SwePub)uud (SwePub)ki
041 a engb eng
042 9 SwePub
072 7a ref2 swepub-contenttype
072 7a art2 swepub-publicationtype
1001 a Lemonnier, Nathanaëlu UGA, INSERM U1209, CNRS, UMR5309,Inst Adv Biosci, Site Sante,Allee Alpes, F-38700 La Tronche, France.4 aut
2451 0a A novel whole blood gene expression signature for asthma, dermatitis, and rhinitis multimorbidity in children and adolescents
264 c 2020-04-23
264 1b WILEY,c 2020
338 a print2 rdacarrier
520 a Background: Allergic diseases often occur in combination (multimorbidity). Human blood transcriptome studies have not addressed multimorbidity. Large-scale gene expression data were combined to retrieve biomarkers and signaling pathways to disentangle allergic multimorbidity phenotypes.Methods: Integrated transcriptomic analysis was conducted in 1233 participants with a discovery phase using gene expression data (Human Transcriptome Array 2.0) from whole blood of 786 children from three European birth cohorts (MeDALL), and a replication phase using RNA Sequencing data from an independent cohort (EVA-PR, n = 447). Allergic diseases (asthma, atopic dermatitis, rhinitis) were considered as single disease or multimorbidity (at least two diseases), and compared with no disease.Results: Fifty genes were differentially expressed in allergic diseases. Thirty-two were not previously described in allergy. Eight genes were consistently overexpressed in all types of multimorbidity for asthma, dermatitis, and rhinitis (CLC, EMR4P, IL5RA, FRRS1, HRH4, SLC29A1, SIGLEC8, IL1RL1). All genes were replicated the in EVA-PR cohort. RT-qPCR validated the overexpression of selected genes. In MeDALL, 27 genes were differentially expressed in rhinitis alone, but none was significant for asthma or dermatitis alone. The multimorbidity signature was enriched in eosinophil-associated immune response and signal transduction. Protein-protein interaction network analysis identified IL5/JAK/STAT and IL33/ST2/IRAK/TRAF as key signaling pathways in multimorbid diseases. Synergistic effect of multimorbidity on gene expression levels was found.Conclusion: A signature of eight genes identifies multimorbidity for asthma, rhinitis, and dermatitis. Our results have clinical and mechanistic implications, and suggest that multimorbidity should be considered differently than allergic diseases occurring alone.
650 7a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Lungmedicin och allergi0 (SwePub)302192 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Respiratory Medicine and Allergy0 (SwePub)302192 hsv//eng
653 a asthma
653 a atopic dermatitis
653 a multimorbidity
653 a rhinitis
653 a transcriptomics
7001 a Melen, Eriku Karolinska Institutet4 aut
7001 a Jiang, Yaleu Univ Pittsburgh, UPMC Childrens Hosp Pittsburgh, Div Pediat Pulm Med, Pittsburgh, PA USA.;Tsinghua Univ, Sch Med, Beijing, Peoples R China.4 aut
7001 a Joly, Stephaneu INSERM, Int Ctr Infectiol Res, CIRI, Lyon, France.4 aut
7001 a Menard, Camilleu INSERM, Int Ctr Infectiol Res, CIRI, Lyon, France.4 aut
7001 a Aguilar, Danielu Biomed Res Networking Ctr Hepat & Digest Dis CIBE, Barcelona, Spain.4 aut
7001 a Acosta-Perez, Ednau Univ Puerto Rico, Behav Sci Res Inst, San Juan, PR 00936 USA.4 aut
7001 a Bergstrom, Annau Karolinska Institutet4 aut
7001 a Boutaoui, Nadiau Univ Pittsburgh, UPMC Childrens Hosp Pittsburgh, Div Pediat Pulm Med, Pittsburgh, PA USA.4 aut
7001 a Bustamante, Marionau Barcelona Inst Global Hlth, ISGlobal, Barcelona, Spain.;UPF, Barcelona, Spain.;Inst Salud Carlos III, Spanish Consortium Res Epidemiol & Publ Hlth CIBE, Madrid, Spain.4 aut
7001 a Canino, Glorisau Univ Puerto Rico, Behav Sci Res Inst, San Juan, PR 00936 USA.4 aut
7001 a Forno, Ericku Univ Pittsburgh, UPMC Childrens Hosp Pittsburgh, Div Pediat Pulm Med, Pittsburgh, PA USA.4 aut
7001 a Ramon Gonzalez, Juanu Barcelona Inst Global Hlth, ISGlobal, Barcelona, Spain.4 aut
7001 a Garcia-Aymerich, Judithu Barcelona Inst Global Hlth, ISGlobal, Barcelona, Spain.4 aut
7001 a Gruzieva, Olenau Karolinska Institutet4 aut
7001 a Guerra, Stefanou Barcelona Inst Global Hlth, ISGlobal, Barcelona, Spain.;Univ Arizona, Asthma & Airway Dis Res Ctr, Tucson, AZ USA.4 aut
7001 a Heinrich, Joachimu Helmholtz Zentrum Munchen, German Res Ctr Environm Hlth, Inst Epidemiol, Munich, Germany.;Univ Hosp Munich LMU, Inner City Clin, Inst & Outpatient Clin Occupat Social & Environm, Munich, Germany.4 aut
7001 a Kull, Ingeru Karolinska Institutet4 aut
7001 a Ibarluzea Maurolagoitia, Jesusu Inst Salud Carlos III, Spanish Consortium Res Epidemiol & Publ Hlth CIBE, Madrid, Spain.;BIODONOSTIA, Inst Invest Sanitaria, Donostia San Sebastian, Spain.4 aut
7001 a Santa-Marina Rodriguez, Loretou Inst Salud Carlos III, Spanish Consortium Res Epidemiol & Publ Hlth CIBE, Madrid, Spain.4 aut
7001 a Thiering, Elisabethu Helmholtz Zentrum Munchen, German Res Ctr Environm Hlth, Inst Epidemiol, Munich, Germany.;Ludwig Maximilians Univ Munchen, Dr von Hauner Childrens Hosp, Div Metab Dis & Nutr Med, Munich, Germany.4 aut
7001 a Wickman, Magnusu Uppsala universitet,Centrum för klinisk forskning i Sörmland (CKFD)4 aut
7001 a Akdis, Cezmiu Univ Zurich, Swiss Inst Allergy & Asthma Res SIAF, Davos, Switzerland.4 aut
7001 a Akdis, Mübeccelu Univ Zurich, Swiss Inst Allergy & Asthma Res SIAF, Davos, Switzerland.4 aut
7001 a Chen, Weiu Univ Pittsburgh, UPMC Childrens Hosp Pittsburgh, Div Pediat Pulm Med, Pittsburgh, PA USA.;Univ Pittsburgh, Dept Biostat, Pittsburgh, PA 15261 USA.4 aut
7001 a Keil, Thomasu Charite Univ Med Berlin, Inst Social Med Epidemiol & Hlth Econ, Berlin, Germany.;Univ Wurzburg, Inst Clin Epidemiol & Biometry, Wurzburg, Germany.;Bavarian Hlth & Food Safety Author, Inst Hlth Resort Med & Hlth Promot, Bad Kissingen, Germany.4 aut
7001 a Koppelman, Gerard H.u Univ Groningen, Univ Med Ctr Groningen, Beatrix Childrens Hosp, Dept Pediat Pulmonol & Pediat Allergol, Groningen, Netherlands.;Univ Groningen, Univ Med Ctr Groningen, GRIAC Res Inst, Groningen, Netherlands.4 aut
7001 a Siroux, Valerieu UGA, INSERM U1209, CNRS, UMR5309,Inst Adv Biosci, Site Sante,Allee Alpes, F-38700 La Tronche, France.4 aut
7001 a Xu, Cheng-Jianu Univ Groningen, Univ Med Ctr Groningen, Beatrix Childrens Hosp, Dept Pediat Pulmonol & Pediat Allergol, Groningen, Netherlands.;Univ Groningen, Univ Med Ctr Groningen, GRIAC Res Inst, Groningen, Netherlands.4 aut
7001 a Hainaut, Pierreu UGA, INSERM U1209, CNRS, UMR5309,Inst Adv Biosci, Site Sante,Allee Alpes, F-38700 La Tronche, France.4 aut
7001 a Standl, Marieu Helmholtz Zentrum Munchen, German Res Ctr Environm Hlth, Inst Epidemiol, Munich, Germany.4 aut
7001 a Sunyer, Jordiu Barcelona Inst Global Hlth, ISGlobal, Barcelona, Spain.4 aut
7001 a Celedon, Juan C.u Univ Pittsburgh, UPMC Childrens Hosp Pittsburgh, Div Pediat Pulm Med, Pittsburgh, PA USA.4 aut
7001 a Maria Anto, Josepu Barcelona Inst Global Hlth, ISGlobal, Barcelona, Spain.4 aut
7001 a Bousquet, Jeanu Fdn Partenariale FMC VIA LR, MACVIA France, Montpellier, France.;Univ Versailles St Quentin En Yvelines, UMR S 1168, Ageing & Chron Dis Epidemiol & Publ Hlth Approach, Montigny Le Bretonneux, France.;Euforea, Brussels, Belgium.;Charite, Comprehens Allergy Ctr, Dept Dermatol & Allergy, Berlin, Germany.4 aut
7102 a Karolinska Institutetb UGA, INSERM U1209, CNRS, UMR5309,Inst Adv Biosci, Site Sante,Allee Alpes, F-38700 La Tronche, France.4 org
7730 t Allergy. European Journal of Allergy and Clinical Immunologyd : WILEYg 75:12, s. 3248-3260q 75:12<3248-3260x 0105-4538x 1398-9995
8564 u https://pure.rug.nl/ws/files/122018046/A_novel_whole_blood_gene_expression_signature_for_asthma_dermatitis_and_rhinitis_multimorbidity_in_children_and_adolescents.pdf
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-450774
8564 8u https://doi.org/10.1111/all.14314
8564 8u http://kipublications.ki.se/Default.aspx?queryparsed=id:143511808

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