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Safinamide in the t...
Safinamide in the treatment pathway of Parkinson’s Disease : a European Delphi Consensus
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- Stocchi, Fabrizio (författare)
- IRCCS San Raffaele Pisana
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- Antonini, Angelo (författare)
- Center for Rare Neurological Diseases (ERN-RND),University of Padova
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- Berg, Daniela (författare)
- University of Kiel,University of Tübingen
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visa fler...
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- Bergmans, Bruno (författare)
- Ghent University Hospital
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- Jost, Wolfgang (författare)
- Parkinson’s Disease Clinic Ortenau
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- Katzenschlager, Regina (författare)
- Karl Landsteiner Institute for Neuroimmunological and Neurodegenerative Disorders
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- Kulisevsky, Jaime (författare)
- CIBER Enfermedades Neurodegenerativas (CIBERNED),Hospital de Sant Pau,Autonomous University of Barcelona
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- Odin, Per (författare)
- Lund University,Lunds universitet,Neurologi, Lund,Sektion IV,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Restorative Parkinson Unit,Forskargrupper vid Lunds universitet,Neurology, Lund,Section IV,Department of Clinical Sciences, Lund,Faculty of Medicine,Lund University Research Groups
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- Valldeoriola, Francesc (författare)
- University of Barcelona,CIBER Enfermedades Neurodegenerativas (CIBERNED),Hospital Clínic of Barcelona,Institutd' Investigacions Biomèdiques August Pi iSunyer (IDIBAPS)
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- Ray Chaudhuri, K. (författare)
- King's College London
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(creator_code:org_t)
- 2022-02-21
- 2022
- Engelska.
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Ingår i: npj Parkinson's Disease. - : Springer Science and Business Media LLC. - 2373-8057. ; 8
- Relaterad länk:
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http://dx.doi.org/10... (free)
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https://www.nature.c...
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https://lup.lub.lu.s...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Safinamide is a highly selective, reversible MAO B-inhibitor recently marketed in European and North American countries. To better define clinical indications regarding motor and non-motor symptoms, targeted population and safety of this compound, ten movement disorders specialists, experts in their field, convened and developed a panel of statements on: the role of glutamate in Parkinson’s disease, introduction to fluctuations, efficacy of safinamide on motor symptoms, motor complications and non-motor symptoms, quality of life, safety of safinamide and target population for use. Strong consensus was reached for all the statements on the efficacy of safinamide on motor symptoms, motor fluctuations, quality of life and safety. Among non-motor symptoms, a positive consensus was reached for the symptoms sleep/fatigue, mood, and pain while there was a lack of consensus for the statements regarding the efficacy of safinamide in improving cognition, urinary and sexual functions. The statement on orthostatic hypotension obtained a negative consensus. The consistent and large agreement reached in this Delphi panel perfectly reflects the perception of efficacy, safety and tolerability of safinamide as evident from pivotal trials and clinical practice and shows how these findings may guide movement disorders specialists in their clinical therapeutic approach. The impact of non-motor symptoms in PD is considerable, and management remains an unmet need. In this context, the ability of safinamide to impact some non-motor symptoms may represent the most promising and distinctive feature of this compound and deserves further investigations.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Neurologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Neurology (hsv//eng)
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Stocchi, Fabrizi ...
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Antonini, Angelo
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Berg, Daniela
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Bergmans, Bruno
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Jost, Wolfgang
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Katzenschlager, ...
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Kulisevsky, Jaim ...
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Odin, Per
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Valldeoriola, Fr ...
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Ray Chaudhuri, K ...
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