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Sökning: WFRF:(Laas J. C.) > (2020-2024) > Predictors of DAPSA...

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FältnamnIndikatorerMetadata
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001oai:gup.ub.gu.se/331555
003SwePub
008240528s2024 | |||||||||||000 ||eng|
009oai:prod.swepub.kib.ki.se:153447658
009oai:lup.lub.lu.se:fbf3b100-aed3-4594-9218-1d6a0fcff35e
024a https://gup.ub.gu.se/publication/3315552 URI
024a https://doi.org/10.1093/rheumatology/kead2842 DOI
024a http://kipublications.ki.se/Default.aspx?queryparsed=id:1534476582 URI
024a https://lup.lub.lu.se/record/fbf3b100-aed3-4594-9218-1d6a0fcff35e2 URI
040 a (SwePub)gud (SwePub)kid (SwePub)lu
041 a eng
042 9 SwePub
072 7a ref2 swepub-contenttype
072 7a art2 swepub-publicationtype
100a Linde, L.u Copenhagen University Hospital,University of Copenhagen4 aut
2451 0a Predictors of DAPSA28 remission in patients with psoriatic arthritis initiating a first TNF inhibitor: results from 13 European registries
264 1c 2024
520 a Objectives In bio-naive patients with PsA initiating a TNF inhibitor (TNFi), we aimed to identify baseline predictors of Disease Activity index for PsA in 28 joints (DAPSA28) remission (primary objective) and DAPSA28 moderate response at 6 months, as well as drug retention at 12 months across 13 European registries. Methods Baseline demographic and clinical characteristics were retrieved and the three outcomes investigated per registry and in pooled data, using logistic regression analyses on multiply imputed data. In the pooled cohort, selected predictors that were either consistently positive or negative across all three outcomes were defined as common predictors. Results In the pooled cohort (n = 13 369), 6-month proportions of remission, moderate response and 12-month drug retention were 25%, 34% and 63% in patients with available data (n = 6954, n = 5275 and n = 13 369, respectively). Five common baseline predictors of remission, moderate response and 12-month drug retention were identified across all three outcomes. The odds ratios (95% CIs) for DAPSA28 remission were: age, per year: 0.97 (0.96-0.98); disease duration, years (<2 years as reference): 2-3 years: 1.20 (0.89-1.60), 4-9 years: 1.42 (1.09-1.84), & GE;10 years: 1.66 (1.26-2.20); men vs women: 1.85 (1.54-2.23); CRP of >10 vs & LE;10 mg/l: 1.52 (1.22-1.89) and 1 mm increase in patient fatigue score: 0.99 (0.98-0.99). Conclusion Baseline predictors of remission, response and adherence to TNFi therapy were identified, of which five were common for all three outcomes, indicating that the predictors emerging from our pooled cohort may be considered generalizable from country level to disease level.
650 7a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Reumatologi och inflammation0 (SwePub)302102 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Rheumatology and Autoimmunity0 (SwePub)302102 hsv//eng
653 a PsA
653 a first TNF-inhibitor
653 a predictors
653 a DAPSA28
653 a drug retention
653 a real-world evidence
653 a health-assessment questionnaire
653 a rheumatoid-arthritis
653 a clinical-response
653 a drug survival
653 a alpha therapy
653 a spondyloarthritis
653 a recommendations
653 a efficacy
653 a outcomes
653 a rates
653 a Rheumatology
700a Ornbjerg, L. M.u Copenhagen University Hospital4 aut
700a Georgiadis, S.u Copenhagen University Hospital4 aut
700a Rasmussen, S. H.4 aut
700a Lindström, Ulfu University of Gothenburg,Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för reumatologi och inflammationsforskning,Institute of Medicine, Department of Rheumatology and Inflammation Research,Sahlgrenska Academy4 aut0 (Swepub:gu)xlulfn
700a Askling, J.u Karolinska Institute,Karolinska Institutet4 aut
700a Michelsen, B.u Diakonhjemmet Hospital,Sørlandet Hospital4 aut
700a Di Giuseppe, D.u Karolinska Institute,Karolinska Institutet4 aut
700a Wallman, Johan K.u Lund University,Lunds universitet,Reumatologi och molekylär skelettbiologi,Sektion III,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Lund Arthritis Research Group (LARG),Forskargrupper vid Lunds universitet,Rheumatology,Section III,Department of Clinical Sciences, Lund,Faculty of Medicine,Lund University Research Groups,Skåne University Hospital4 aut0 (Swepub:lu)med-jnk
700a Gudbjornsson, B.u National University Hospital of Iceland4 aut
700a Love, T. J.u National University Hospital of Iceland4 aut
700a Nordstrom, D. C.u Helsinki University Central Hospital,Carol Davila University of Medicine and Pharmacy4 aut
700a Yli-Kerttula, T.u Satakunta Central Hospital4 aut
700a Nekvindova, L.u Charles University in Prague,Institute of Rheumatology, Prague4 aut
700a Vencovsky, J.u Charles University in Prague,Institute of Rheumatology, Prague4 aut
700a Iannone, F.u University of Bari Aldo Moro4 aut
700a Cauli, A.u University of Cagliari4 aut
700a Loft, A. G.u Aarhus University Hospital,Aarhus University4 aut
700a Glintborg, B.u University of Copenhagen,Copenhagen University Hospital4 aut
700a Laas, K.4 aut
700a Rotar, Z.u University of Ljubljana,University Medical Centre Ljubljana4 aut
700a Tomsic, M.u University Medical Centre Ljubljana,University of Ljubljana4 aut
700a Macfarlane, G. J.4 aut
700a Moller, B.u Bern University Hospital4 aut
700a van de Sande, M.u University of Amsterdam4 aut
700a Codreanu, C.4 aut
700a Nissen, M. J.u Geneva University Hospital4 aut
700a Birlik, M.u Dokuz Eylül University4 aut
700a Erten, S.4 aut
700a Santos, M. J.u Hospital Garcia de Orta4 aut
700a Vieira-Sousa, E.u University of Lisbon4 aut
700a Hetland, M. L.4 aut
700a Ostergaard, M.u University of Copenhagen4 aut
710a Copenhagen University Hospitalb University of Copenhagen4 org
773t Rheumatologyg 63:3, s. 751-764q 63:3<751-764x 1462-0324
773t Rheumatology (Oxford, England)g 63:3, s. 751-764q 63:3<751-764x 1462-0332
856u http://dx.doi.org/10.1093/rheumatology/kead284x freey FULLTEXT
8564 8u https://gup.ub.gu.se/publication/331555
8564 8u https://doi.org/10.1093/rheumatology/kead284
8564 8u http://kipublications.ki.se/Default.aspx?queryparsed=id:153447658
8564 8u https://lup.lub.lu.se/record/fbf3b100-aed3-4594-9218-1d6a0fcff35e

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