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Bi-parametric MRI/T...
Bi-parametric MRI/TRUS fusion targeted repeat biopsy after systematic 10-12 core TRUS-guided biopsy reveals more significant prostate cancer especially in anteriorly located tumors
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- Häggman, Michael (författare)
- Uppsala universitet,Urologkirurgi
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- Dahlman, Par (författare)
- Uppsala universitet,Radiologi,Uppsala Univ Hosp, Dept Radiol, Uppsala, Sweden.
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- Ahlberg, Mats (författare)
- Uppsala Univ Hosp, Dept Urol, S-75185 Uppsala, Sweden.
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- Liss, Per (författare)
- Uppsala universitet,Radiologi,Uppsala Univ Hosp, Dept Radiol, Uppsala, Sweden.
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- Ahlman, Rafaele Cantera (författare)
- Uppsala Univ Hosp, Dept Urol, S-75185 Uppsala, Sweden.
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- Dragomir, Anca (författare)
- Uppsala universitet,Institutionen för immunologi, genetik och patologi,Uppsala Univ Hosp, Dept Pathol, Uppsala, Sweden.
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- Ladjevardi, Sam (författare)
- Uppsala Univ Hosp, Dept Urol, S-75185 Uppsala, Sweden.
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(creator_code:org_t)
- 2022-03-31
- 2022
- Engelska.
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Ingår i: Acta Radiologica Open. - : SAGE Publications. - 2058-4601. ; 11:3
- Relaterad länk:
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https://doi.org/10.1...
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https://uu.diva-port... (primary) (Raw object)
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Background: MRI and fusion guided biopsy have an increased role in the diagnosis of prostate cancer. Purpose: To demonstrate the possible advantages with Bi-parametric MRI fusion-guided repeat biopsy over systematic 10-12-core biopsy for the diagnosis of prostate cancer. Material and Methods: Four hundred and twenty-three consecutive men, with previous systematic 10-12-core TRUS-guided biopsy, and with suspicion of, or diagnosis of, low-risk prostate cancer underwent fusion-guided prostate biopsy between February 2015 and February 2017. The material was retrospectively assessed. In 220 cases no previous cancer was diagnosed, and in 203 cases confirmatory fusion guided biopsy was performed prior to active monitoring. MRI was classified according to PI-RADS. Systematic biopsy was compared to fusion guided biopsy for the detection of cancer, and PI-RADS was compared to the Gleason score. Results: Fusion guided biopsy detected significantly more cancers than systematic (p < .001). Gleason scores were higher in the fusion biopsy group (p < .001). Anterior tumors were present in 54% of patients. Fusion biopsy from these lesions showed cancer in 53% with previously negative biopsy in systematic biopsies and 66% of them were upgraded from low risk to intermediate or high-risk cancers. Conclusion: These results show superior detection rate and grading of bi-parametric MRI/TRUS fusion targeted repeat biopsy over systematic 10-12 core biopsies. Fusion guided biopsy detects more significant cancers despite using fewer cores. The risk group was changed for many patients initially selected for active surveillance due to upgrading of tumors. Bi-parametric MRI shows promising results in detecting anterior tumors in patients with suspected prostate cancer.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Urologi och njurmedicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Urology and Nephrology (hsv//eng)
Nyckelord
- Prostate cancer
- MRI
- Bi-parametric MRI
- fusion guided biopsy
- transrectal ultrasound
- diagnosis
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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