WFRF:(Lakatos L.)
Sökning: WFRF:(Lakatos L.) > (2015-2019) > Natural disease cou...
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| Fältnamn | Indikatorer | Metadata |
|---|---|---|
| 000 | 12083naa a2201513 4500 | |
| 001 | oai:prod.swepub.kib.ki.se:141202547 | |
| 003 | SwePub | |
| 008 | 240911s2019 | |||||||||||000 ||eng| | |
| 009 | oai:DiVA.org:oru-64714 | |
| 024 | 7 | a http://kipublications.ki.se/Default.aspx?queryparsed=id:1412025472 URI |
| 024 | 7 | a https://doi.org/10.1136/gutjnl-2017-3155682 DOI |
| 024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-647142 URI |
| 040 | a (SwePub)kid (SwePub)oru | |
| 041 | a engb eng | |
| 042 | 9 SwePub | |
| 072 | 7 | a ref2 swepub-contenttype |
| 072 | 7 | a art2 swepub-publicationtype |
| 100 | 1 | a Burisch, Ju Department of Gastroenterology, Nordsjællands Hospital, University of Copenhagen, Frederikssund, Denmark4 aut |
| 245 | 1 0 | a Natural disease course of Crohn's disease during the first 5 years after diagnosis in a European population-based inception cohort: an Epi-IBD study |
| 264 | c 2018-01-23 | |
| 264 | 1 | b BMJ,c 2019 |
| 500 | a Funding Agencies:Kirsten og Freddy Johansens Fond Nordsjaellands Hospital Forskningsrad | |
| 520 | a The Epi-IBD cohort is a prospective population-based inception cohort of unselected patients with inflammatory bowel disease from 29 European centres covering a background population of almost 10 million people. The aim of this study was to assess the 5-year outcome and disease course of patients with Crohn’s disease (CD).DesignPatients were followed up prospectively from the time of diagnosis, including collection of their clinical data, demographics, disease activity, medical therapy, surgery, cancers and deaths. Associations between outcomes and multiple covariates were analysed by Cox regression analysis.ResultsIn total, 488 patients were included in the study. During follow-up, 107 (22%) patients received surgery, while 176 (36%) patients were hospitalised because of CD. A total of 49 (14%) patients diagnosed with non-stricturing, non-penetrating disease progressed to either stricturing and/or penetrating disease. These rates did not differ between patients from Western and Eastern Europe. However, significant geographic differences were noted regarding treatment: more patients in Western Europe received biological therapy (33%) and immunomodulators (66%) than did those in Eastern Europe (14% and 54%, respectively, P<0.01), while more Eastern European patients received 5-aminosalicylates (90% vs 56%, P<0.05). Treatment with immunomodulators reduced the risk of surgery (HR: 0.4, 95% CI 0.2 to 0.6) and hospitalisation (HR: 0.3, 95% CI 0.2 to 0.5).ConclusionDespite patients being treated early and frequently with immunomodulators and biological therapy in Western Europe, 5-year outcomes including surgery and phenotype progression in this cohort were comparable across Western and Eastern Europe. Differences in treatment strategies between Western and Eastern European centres did not affect the disease course. Treatment with immunomodulators reduced the risk of surgery and hospitalisation. | |
| 650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Gastroenterologi0 (SwePub)302132 hsv//swe |
| 650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Gastroenterology and Hepatology0 (SwePub)302132 hsv//eng |
| 650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Hälsovetenskapx Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi0 (SwePub)303022 hsv//swe |
| 650 | 7 | a MEDICAL AND HEALTH SCIENCESx Health Sciencesx Public Health, Global Health, Social Medicine and Epidemiology0 (SwePub)303022 hsv//eng |
| 653 | a Crohn’s disease | |
| 700 | 1 | a Kiudelis, Gu Institute for Digestive Research, Medical Academy, Lithuanian University of Health Sciences, Kaunas, Lithuania4 aut |
| 700 | 1 | a Kupcinskas, Lu Institute for Digestive Research, Medical Academy, Lithuanian University of Health Sciences, Kaunas, Lithuania; Department of Gastroenterology, Medical Academy, Lithuanian University of Health Sciences, Kaunas, Lithuania4 aut |
| 700 | 1 | a Kievit, HALu Department of Medicine, Herning Central Hospital, Herning, Denmark4 aut |
| 700 | 1 | a Andersen, KWu Medical Department, Regional Hospital of Viborg, Viborg, Denmark4 aut |
| 700 | 1 | a Andersen, Vu Medical Department, Regional Hospital of Viborg, Viborg, Denmark; Focused research unit for Molecular Diagnostic and Clinical Research (MOK), IRS-Center Sonderjylland, Hospital of Southern Jutland, Aabenraa, Denmark4 aut |
| 700 | 1 | a Salupere, Ru Division of Gastroenterology, Tartu University Hospital, University of Tartyu, Tartu, Estonia4 aut |
| 700 | 1 | a Pedersen, Nu Gastroenterology Department, Slagelse Hospital, Slagelse, Denmark4 aut |
| 700 | 1 | a Kjeldsen, Ju Gastroenterology Department, Odense University Hospital, Odense, Denmark4 aut |
| 700 | 1 | a D'Inca, Ru Department of Surgical, Oncological and Gastroenterological Sciences, Azienda, University of Padua, Padova, Italy,IBD Clinical and Research Centre (ISCARE), Prague, Czech Republic4 aut |
| 700 | 1 | a Valpiani, Du U.O. Gastroenterologia ed Endoscopia digestiva, Hospital Morgagni Pierantoni, Forlì, Italy4 aut |
| 700 | 1 | a Schwartz, Du Department of Gastroenterology and Hepatology, Soroka Medical Center, Ben Gurion University of the Negev, Beer Sheva, Israel4 aut |
| 700 | 1 | a Odes, Su Department of Gastroenterology and Hepatology, Soroka Medical Center, Ben Gurion University of the Negev, Beer Sheva, Israel4 aut |
| 700 | 1 | a Olsen, Ju Medical Department, The National Hospital of the Faroe Islands, Thorshavn, Denmark4 aut |
| 700 | 1 | a Nielsen, KRu Medical Department, The National Hospital of the Faroe Islands, Thorshavn, Denmark4 aut |
| 700 | 1 | a Vegh, Zu 1st Department of Medicine, Semmelweis University, Budapest, Hungary4 aut |
| 700 | 1 | a Lakatos, PLu 1st Department of Medicine, Semmelweis University, Budapest, Hungary; Division of Gastroenterology, McGill University Health Center, Montreal, Canada4 aut |
| 700 | 1 | a Toca, Au Department of Gastroenterology, State University of Medicine and Pharmacy of the Republic of Moldova, Chisinau, Republic of Moldova4 aut |
| 700 | 1 | a Turcan, Su Department of Gastroenterology, State University of Medicine and Pharmacy of the Republic of Moldova, Chisinau, Republic of Moldova4 aut |
| 700 | 1 | a Katsanos, KHu Department of Gastroenterology, University Hospital of Ioannina, Ioannina, Greece4 aut |
| 700 | 1 | a Christodoulou, DKu Department of Gastroenterology, University Hospital of Ioannina, Ioannina, Greece4 aut |
| 700 | 1 | a Fumery, Mu Gastroenterology Unit, Epimad Registry, Centre hospitalier universitaire (CHU) Amiens Sud, Amiens University Hospital, Amiens, France4 aut |
| 700 | 1 | a Gower-Rousseau, Cu Public Health, Epidemiology and Economic Health, Registre Epimad, Lille Hospital, Lille University, Lille, France; Lille Inflammation Research International Center (LIRIC), Lille University, Lille, France4 aut |
| 700 | 1 | a Zammit, SCu Division of Gastroenterology, Mater Dei Hospital, Msida, Malta,IBD Unit, Hull and East Yorkshire NHS Trust, Hull, UK4 aut |
| 700 | 1 | a Ellul, Pu Division of Gastroenterology, Mater Dei Hospital, Msida, Malta4 aut |
| 700 | 1 | a Eriksson, Carl,d 1981-u Örebro universitet,Institutionen för medicinska vetenskaper,Department of Gastroenterology, Faculty of Health and Medical Sciences, Örebro University, Örebro, Sweden4 aut0 (Swepub:oru)clen |
| 700 | 1 | a Halfvarson, Jonas,d 1970-u Örebro universitet,Institutionen för medicinska vetenskaper,Department of Gastroenterology, Faculty of Health and Medical Sciences, Örebro University, Örebro, Sweden4 aut0 (Swepub:oru)jshn |
| 700 | 1 | a Magro, FJu Department of Gastroenterology, Centro Hospitalar de São João EPE, Porto, Portugal; Department of Biomedicine, Institute of Pharmacology, Faculty of Medicine, Porto University, Porto, Portugal4 aut |
| 700 | 1 | a Duricova, D4 aut |
| 700 | 1 | a Bortlik, Mu IBD Clinical and Research Centre (ISCARE), Prague, Czech Republic; Institute of Pharmacology, 1st Faculty of Medicine, Charles University in Prague, Prague, Czech Republic4 aut |
| 700 | 1 | a Fernandez, Au Department of Gastroenterology, Hospital POVISA, Vigo, Spain4 aut |
| 700 | 1 | a Hernandez, Vu Department of Gastroenterology, Hospital Alvaro Cunqueiro. Instituto Investigación Sanitaria Galicia Sur. EOXI de Vigo, Vigo, Spain4 aut |
| 700 | 1 | a Myers, Su IBD Unit, Hull and East Yorkshire NHS Trust, Hull, UK4 aut |
| 700 | 1 | a Sebastian, S4 aut |
| 700 | 1 | a Oksanen, Pu Department of Gastroenterology and Alimentary Tract Surgery, Tampere University Hospital, Tampere, Finland; University of Tampere, Tampere, Finland4 aut |
| 700 | 1 | a Collin, Pu University of Tampere, Tampere, Finland4 aut |
| 700 | 1 | a Goldis, Au Clinic of Gastroenterology, University of Medicine 'Victor Babes', Timisoara, Romania4 aut |
| 700 | 1 | a Misra, Ru IBD Department, Imperial College London, London, UK4 aut |
| 700 | 1 | a Arebi, Nu IBD Department, Imperial College London, London, UK4 aut |
| 700 | 1 | a Kaimakliotis, IPu Nicosia private practice, Nicosia, Cyprus4 aut |
| 700 | 1 | a Nikuina, Iu Department of Gastroenterology, Moscow Regional Research Clinical Institute, Moscow, Russian Federation4 aut |
| 700 | 1 | a Belousova, Eu Department of Gastroenterology, Moscow Regional Research Clinical Institute, Moscow, Russian Federation4 aut |
| 700 | 1 | a Brinar, Mu Division of Gastroenterology and Hepatology, University Hospital Center Zagreb, Zagreb, Croatia4 aut |
| 700 | 1 | a Cukovic-Cavka, Su Division of Gastroenterology and Hepatology, University Hospital Center Zagreb, Zagreb, Croatia4 aut |
| 700 | 1 | a Langholz, Eu Department of Gastroenterology, Herlev and Gentofte Hospital, University of Copenhagen, Herlev, Denmark4 aut |
| 700 | 1 | a Munkholm, Pu Department of Gastroenterology, Nordsjællands Hospital, University of Copenhagen, Frederikssund, Denmark4 aut |
| 700 | 1 | a Niewiadomski, O4 aut |
| 700 | 1 | a Bell, S4 aut |
| 700 | 1 | a Turk, N4 aut |
| 700 | 1 | a Cukovic-Cavka, S4 aut |
| 700 | 1 | a Kaimakliotis, I4 aut |
| 700 | 1 | a Nicolaou, A4 aut |
| 700 | 1 | a Duricova, D4 aut |
| 700 | 1 | a Lukas, M4 aut |
| 700 | 1 | a Bortlik, M4 aut |
| 700 | 1 | a Shonova, O4 aut |
| 700 | 1 | a Burisch, J4 aut |
| 700 | 1 | a Munkholm, P4 aut |
| 700 | 1 | a Langholz, E4 aut |
| 700 | 1 | a Blichfeldt, B4 aut |
| 700 | 1 | a Marker, D4 aut |
| 700 | 1 | a Carlsen, K4 aut |
| 700 | 1 | a Weimers, P4 aut |
| 700 | 1 | a Pedersen, N4 aut |
| 700 | 1 | a Kjeldsen, J4 aut |
| 700 | 1 | a Aalykke, C4 aut |
| 700 | 1 | a Dahlerup, JF4 aut |
| 700 | 1 | a Kudsk, K4 aut |
| 700 | 1 | a Andersen, V4 aut |
| 700 | 1 | a Vind, I4 aut |
| 700 | 1 | a Thorsgaard, N4 aut |
| 700 | 1 | a Salupere, R4 aut |
| 700 | 1 | a Olsen, J4 aut |
| 700 | 1 | a Nielsen, KR4 aut |
| 700 | 1 | a Oksanen, P4 aut |
| 700 | 1 | a Collin, P4 aut |
| 700 | 1 | a Katsanos, KH4 aut |
| 700 | 1 | a Christodoulou, DK4 aut |
| 700 | 1 | a Skamnelos, A4 aut |
| 700 | 1 | a Politis, D4 aut |
| 700 | 1 | a Ladefoged, K4 aut |
| 700 | 1 | a Lakatos, PL4 aut |
| 700 | 1 | a Vegh, Z4 aut |
| 700 | 1 | a Lakatos, L4 aut |
| 700 | 1 | a Demenyi, P4 aut |
| 700 | 1 | a Kramli, SN4 aut |
| 700 | 1 | a O'Morain, C4 aut |
| 700 | 1 | a Dal Piaz, G4 aut |
| 700 | 1 | a Santini, A4 aut |
| 700 | 1 | a Girardin, G4 aut |
| 700 | 1 | a D'Inca, R4 aut |
| 700 | 1 | a Schwartz, D4 aut |
| 700 | 1 | a Odes, S4 aut |
| 700 | 1 | a Kupcinskas, L4 aut |
| 700 | 1 | a Jonaitis, L4 aut |
| 700 | 1 | a Kiudelis, G4 aut |
| 700 | 1 | a Valantiene, I4 aut |
| 710 | 2 | a Department of Gastroenterology, Nordsjællands Hospital, University of Copenhagen, Frederikssund, Denmarkb Institute for Digestive Research, Medical Academy, Lithuanian University of Health Sciences, Kaunas, Lithuania4 org |
| 773 | 0 | t Gutd : BMJg 68:3, s. 423-433q 68:3<423-433x 1468-3288x 0017-5749 |
| 856 | 4 8 | u http://kipublications.ki.se/Default.aspx?queryparsed=id:141202547 |
| 856 | 4 8 | u https://doi.org/10.1136/gutjnl-2017-315568 |
| 856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-64714 |
Hitta mer i SwePub
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- Burisch, J
- Kiudelis, G
- Kupcinskas, L
- Kievit, HAL
- Andersen, KW
- Andersen, V
- visa fler...
- Salupere, R
- Pedersen, N
- Kjeldsen, J
- D'Inca, R
- Valpiani, D
- Schwartz, D
- Odes, S
- Olsen, J
- Nielsen, KR
- Vegh, Z
- Lakatos, PL
- Toca, A
- Turcan, S
- Katsanos, KH
- Christodoulou, D ...
- Fumery, M
- Gower-Rousseau, ...
- Zammit, SC
- Ellul, P
- Eriksson, Carl, ...
- Halfvarson, Jona ...
- Magro, FJ
- Duricova, D
- Bortlik, M
- Fernandez, A
- Hernandez, V
- Myers, S
- Sebastian, S
- Oksanen, P
- Collin, P
- Goldis, A
- Misra, R
- Arebi, N
- Kaimakliotis, IP
- Nikuina, I
- Belousova, E
- Brinar, M
- Cukovic-Cavka, S
- Langholz, E
- Munkholm, P
- Niewiadomski, O
- Bell, S
- Turk, N
- Kaimakliotis, I
- Nicolaou, A
- Lukas, M
- Shonova, O
- Blichfeldt, B
- Marker, D
- Carlsen, K
- Weimers, P
- Aalykke, C
- Dahlerup, JF
- Kudsk, K
- Vind, I
- Thorsgaard, N
- Skamnelos, A
- Politis, D
- Ladefoged, K
- Lakatos, L
- Demenyi, P
- Kramli, SN
- O'Morain, C
- Dal Piaz, G
- Santini, A
- Girardin, G
- Jonaitis, L
- Valantiene, I
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