WFRF:(Ledri Marco)
Sökning: WFRF:(Ledri Marco) > Neuronal activity d...
LIBRIS Formathandbok (Information om MARC21)
| Fältnamn | Indikatorer | Metadata |
|---|---|---|
| 000 | 04471naa a2200409 4500 | |
| 001 | oai:lup.lub.lu.se:0ae427a9-95ef-47b5-aaec-78ad98422072 | |
| 003 | SwePub | |
| 008 | 230912s2023 | |||||||||||000 ||eng| | |
| 024 | 7 | a https://lup.lub.lu.se/record/0ae427a9-95ef-47b5-aaec-78ad984220722 URI |
| 024 | 7 | a https://doi.org/10.1016/j.eplepsyres.2023.1071822 DOI |
| 040 | a (SwePub)lu | |
| 041 | a engb eng | |
| 042 | 9 SwePub | |
| 072 | 7 | a art2 swepub-publicationtype |
| 072 | 7 | a ref2 swepub-contenttype |
| 100 | 1 | a Berglind, Fredriku Lund University,Lunds universitet,Epilepsicentrum,Sektion IV,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Epilepsy Center,Section IV,Department of Clinical Sciences, Lund,Faculty of Medicine4 aut0 (Swepub:lu)med-fbe |
| 245 | 1 0 | a Neuronal activity dynamics in the dentate gyrus during early epileptogenesis |
| 264 | 1 | c 2023 |
| 520 | a Epileptogenesis is a complex process involving a multitude of changes at the molecular, cellular and network level. Previous studies have identified several key alterations contributing to epileptogenesis and the development of hyper-excitability in different animal models, but only a few have focused on the early stages of this process. For post status epilepticus (SE) temporal lobe epilepsy in particular, understanding network dynamics during the early phases might be crucial for developing accurate preventive treatments to block the development of chronic spontaneous seizures. In this study, we used a viral vector mediated approach to examine activity of neurons in the dentate gyrus of the hippocampus during early epileptogenesis. We find that while granule cells are active 8 h after SE and then gradually decrease their activity, Calretinin-positive mossy cells and Neuropeptide Y-positive GABAergic interneurons in the hilus show a delayed activation pattern starting at 24 and peaking at 48 h after SE. These data suggest that indirect inhibition of granule cells by mossy cells through recruitment of local GABAergic interneurons could be an important mechanisms of excitability control during early epileptogenesis, and contribute to our understanding of the complex role of these cells in normal and pathological conditions. | |
| 650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Medicinska och farmaceutiska grundvetenskaperx Neurovetenskaper0 (SwePub)301052 hsv//swe |
| 650 | 7 | a MEDICAL AND HEALTH SCIENCESx Basic Medicinex Neurosciences0 (SwePub)301052 hsv//eng |
| 653 | a Calretinin | |
| 653 | a Epileptogenesis | |
| 653 | a Kainic Acid | |
| 653 | a Mossy Cells | |
| 653 | a RAM | |
| 700 | 1 | a Boulot, Adrienu Lund University,Lunds universitet,Epilepsicentrum,Sektion IV,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Epilepsy Center,Section IV,Department of Clinical Sciences, Lund,Faculty of Medicine4 aut0 (Swepub:lu)ad4684bo |
| 700 | 1 | a Gonzalez-Ramos, Anau Lund University,Lunds universitet,Epilepsicentrum,Sektion IV,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Epilepsy Center,Section IV,Department of Clinical Sciences, Lund,Faculty of Medicine4 aut0 (Swepub:lu)med-agm |
| 700 | 1 | a Melin, Esbjörnu Lund University,Lunds universitet,Epilepsicentrum,Sektion IV,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Experimentell Epilepsi,Forskargrupper vid Lunds universitet,Epilepsy Center,Section IV,Department of Clinical Sciences, Lund,Faculty of Medicine,Experimental Epilepsy Group,Lund University Research Groups4 aut0 (Swepub:lu)med-erm |
| 700 | 1 | a Bono, Antoninou Lund University4 aut |
| 700 | 1 | a Sørensen, Andreas Toftu University of Copenhagen4 aut |
| 700 | 1 | a Ledri, Marcou Lund University,Lunds universitet,Epilepsicentrum,Sektion IV,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Experimentell Epilepsi,Forskargrupper vid Lunds universitet,Molekylär Neurofysiologi och Epilepsi,Epilepsy Center,Section IV,Department of Clinical Sciences, Lund,Faculty of Medicine,Experimental Epilepsy Group,Lund University Research Groups,Molecular Neurophysiology and Epilepsy group4 aut0 (Swepub:lu)ma6384le |
| 710 | 2 | a Epilepsicentrumb Sektion IV4 org |
| 773 | 0 | t Epilepsy Researchg 194q 194x 0920-1211 |
| 856 | 4 | u http://dx.doi.org/10.1016/j.eplepsyres.2023.107182x freey FULLTEXT |
| 856 | 4 8 | u https://lup.lub.lu.se/record/0ae427a9-95ef-47b5-aaec-78ad98422072 |
| 856 | 4 8 | u https://doi.org/10.1016/j.eplepsyres.2023.107182 |
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