SwePub
Sök i LIBRIS databas

  Utökad sökning

WFRF:(Lerch S)
 

Sökning: WFRF:(Lerch S) > (2010-2014) > Association of non-...

LIBRIS Formathandbok  (Information om MARC21)
FältnamnIndikatorerMetadata
00010278naa a2200733 4500
001oai:DiVA.org:liu-109985
003SwePub
008140829s2014 | |||||||||||000 ||eng|
009oai:prod.swepub.kib.ki.se:129629888
0247 a https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-1099852 URI
0247 a https://doi.org/10.1371/journal.pmed.10016802 DOI
0247 a http://kipublications.ki.se/Default.aspx?queryparsed=id:1296298882 URI
040 a (SwePub)liud (SwePub)ki
041 a engb eng
042 9 SwePub
072 7a ref2 swepub-contenttype
072 7a art2 swepub-publicationtype
1001 a Musso, G.u Gradenigo Hospital, University of Turin, Turin, Italy4 aut
2451 0a Association of non-alcoholic fatty liver disease with chronic kidney disease :b a systematic review and meta-analysis
264 c 2014-07-22
264 1b Public Library of Science,c 2014
338 a electronic2 rdacarrier
520 a Background:Chronic kidney disease (CKD) is a frequent, under-recognized condition and a risk factor for renal failure and cardiovascular disease. Increasing evidence connects non-alcoholic fatty liver disease (NAFLD) to CKD. We conducted a meta-analysis to determine whether the presence and severity of NAFLD are associated with the presence and severity of CKD.Methods and Findings:English and non-English articles from international online databases from 1980 through January 31, 2014 were searched. Observational studies assessing NAFLD by histology, imaging, or biochemistry and defining CKD as either estimated glomerular filtration rate (eGFR) andlt;60 ml/min/1.73 m2 or proteinuria were included. Two reviewers extracted studies independently and in duplicate. Individual participant data (IPD) were solicited from all selected studies. Studies providing IPD were combined with studies providing only aggregate data with the two-stage method. Main outcomes were pooled using random-effects models. Sensitivity and subgroup analyses were used to explore sources of heterogeneity and the effect of potential confounders. The influences of age, whole-body/abdominal obesity, homeostasis model of insulin resistance (HOMA-IR), and duration of follow-up on effect estimates were assessed by meta-regression. Thirty-three studies (63,902 participants, 16 population-based and 17 hospital-based, 20 cross-sectional, and 13 longitudinal) were included. For 20 studies (61% of included studies, 11 cross-sectional and nine longitudinal, 29,282 participants), we obtained IPD. NAFLD was associated with an increased risk of prevalent (odds ratio [OR] 2.12, 95% CI 1.69-2.66) and incident (hazard ratio [HR] 1.79, 95% CI 1.65-1.95) CKD. Non-alcoholic steatohepatitis (NASH) was associated with a higher prevalence (OR 2.53, 95% CI 1.58-4.05) and incidence (HR 2.12, 95% CI 1.42-3.17) of CKD than simple steatosis. Advanced fibrosis was associated with a higher prevalence (OR 5.20, 95% CI 3.14-8.61) and incidence (HR 3.29, 95% CI 2.30-4.71) of CKD than non-advanced fibrosis. In all analyses, the magnitude and direction of effects remained unaffected by diabetes status, after adjustment for other risk factors, and in other subgroup and meta-regression analyses. In cross-sectional and longitudinal studies, the severity of NAFLD was positively associated with CKD stages. Limitations of analysis are the relatively small size of studies utilizing liver histology and the suboptimal sensitivity of ultrasound and biochemistry for NAFLD detection in population-based studies.Conclusion:The presence and severity of NAFLD are associated with an increased risk and severity of CKD.Please see later in the article for the Editors Summary. © 2014 Musso et al.
650 7a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicin0 (SwePub)3022 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Clinical Medicine0 (SwePub)3022 hsv//eng
7001 a Gambino, R.u Dept. of Medical Sciences, San Giovanni Battista Hospital, University of Turin, Turin, Italy4 aut
7001 a Tabibian, J.H.u Karolinska Institutet,Division of Gastroenterology and Hepatology Mayo Clinic, Rochester, MN, United States,Departments of Gastroenterology and Hepatology, Karolinska University Hospital, Karolinska Institutet, Stockholm, Sweden4 aut
7001 a Ekstedt, Mattiasu Östergötlands Läns Landsting,Linköpings universitet,Avdelningen för inflammationsmedicin,Hälsouniversitetet,Magtarmmedicinska kliniken4 aut0 (Swepub:liu)matek92
7001 a Kechagias, Stergiosu Östergötlands Läns Landsting,Linköpings universitet,Avdelningen för kardiovaskulär medicin,Hälsouniversitetet,Magtarmmedicinska kliniken,Division of Hepato-Gastroenterology, Department of Internal Medicine, Kangnam St. Mary Hospital, Catholic University Medical College, Seoul, South Korea4 aut0 (Swepub:liu)steke00
7001 a Hamaguchi, M.u Department of Experimental Immunology, World Premier International Immunology Frontier Research Center, Osaka University, Osaka, Japan4 aut
7001 a Hultcrantz, R.u Karolinska Institutet,Departments of Gastroenterology and Hepatology, Karolinska University Hospital, Karolinska Institutet, Stockholm, Sweden4 aut
7001 a Hagstrom, H.u Departments of Gastroenterology and Hepatology, Karolinska University Hospital, Karolinska Institutet, Stockholm, Sweden,Institute for Community Medicine, Ernst-Moritz-Arndt University Medicine Greifswald, Greifswald, Germany,Department of Gastroenterology, University Hospital of Santa Maria, Institute of Molecular Medicine, Lisbon, Portugal4 aut
7001 a Yoon, S.K.u Division of Hepato-Gastroenterology, Department of Internal Medicine, Kangnam St. Mary Hospital, Catholic University Medical College, Seoul, South Korea4 aut
7001 a Charatcharoenwitthaya, P.u Division of Gastroenterology, Medicine Department, Siriraj Hospital, Mahidol University, Bangkoknoi, Bangkok, Thailand4 aut
7001 a George, J.u Storr Liver Unit, Westmead Millennium Institute, University of Sydney and Department of Gastroenterology and Hepatology, Westmead Hospital, Westmead, NSW, Australia4 aut
7001 a Barrera, F.u Storr Liver Unit, Westmead Millennium Institute, University of Sydney and Department of Gastroenterology and Hepatology, Westmead Hospital, Westmead, NSW, Australia4 aut
7001 a Haflidadottir, S.u Dept of Gastroenterology and Hepatology, Landspitali University Hospital, Hringbrau, Reykjavik, Iceland4 aut
7001 a Bjornsson, E.S.u Dept of Gastroenterology and Hepatology, Landspitali University Hospital, Hringbrau, Reykjavik, Iceland4 aut
7001 a Armstrong, M.J.u Centre for Liver Research and NIHR Biomedical Research Unit in Liver Disease, Institute of Biomedical Research, University of Birmingham, Birmingham, United Kingdom,Department of Gastroenterology, University Hospital of Santa Maria, Institute of Molecular Medicine, Lisbon, Portugal4 aut
7001 a Hopkins, L.J.u Centre for Liver Research and NIHR Biomedical Research Unit in Liver Disease, Institute of Biomedical Research, University of Birmingham, Birmingham, United Kingdom4 aut
7001 a Gao, X.u Department of Endocrinology and Metabolism, Zhongshan Hospital, Fudan University, Shanghai, China4 aut
7001 a Francque, S.u Department of Gastroenterology and Hepatology, Antwerp University Hospital, University of Antwerp, Antwerp, Belgium4 aut
7001 a Verrijken, A.u Department of Endocrinology, Diabetology and Metabolism, Antwerp University Hospital, University of Antwerp, Antwerp, Belgium4 aut
7001 a Yilmaz, Y.u Department of Gastroenterology, Marmara University, School of Medicine, Istanbul, Turkey4 aut
7001 a Lindor, K.D.u Division of Gastroenterology and Hepatology Mayo Clinic, Rochester, MN, United States4 aut
7001 a Charlton, M.u Division of Gastroenterology and Hepatology Mayo Clinic, Rochester, MN, United States4 aut
7001 a Haring, R.u Institute of Clinical Chemistry and Laboratory Medicine, Ernst-Moritz-Arndt University Greifswald, Greifswald, Germany4 aut
7001 a Lerch, M.M.u Department of Medicine A, University Medicine Greifswald, Greifswald, Germany4 aut
7001 a Rettig, R.u Institute of Physiology, Ernst-Moritz-Arndt-University Medicine Greifswald, Karlsburg, Germany4 aut
7001 a Volzke, H.u Institute for Community Medicine, Ernst-Moritz-Arndt University Medicine Greifswald, Greifswald, Germany4 aut
7001 a Ryu, S.u Department of Occupational and Environmental Medicine, Kangbuk Samsung Hospital, Sungkyunkwan University, School of Medicine, Seoul, South Korea4 aut
7001 a Li, G.u College of Life Sciences, Hunan Normal University, Changsha, China4 aut
7001 a Wong, L.L.u John A. Burns School of Medicine at University of Hawaii, Transplant Institute, Hawaii Medical Center, Honolulu, HI, United States4 aut
7001 a Machado, M.u Department of Gastroenterology, University Hospital of Santa Maria, Institute of Molecular Medicine, Lisbon, Portugal,Dept. of Medical Sciences, San Giovanni Battista Hospital, University of Turin, Turin, Italy4 aut
7001 a Cortez-Pinto, H.u Department of Gastroenterology, University Hospital of Santa Maria, Institute of Molecular Medicine, Lisbon, Portugal4 aut
7001 a Yasui, K.u Department of Molecular Gastroenterology and Hepatology, Kyoto Prefectural University of Medicine, Japan4 aut
7001 a Cassader, M.u Dept. of Medical Sciences, San Giovanni Battista Hospital, University of Turin, Turin, Italy4 aut
7102 a Gradenigo Hospital, University of Turin, Turin, Italyb Dept. of Medical Sciences, San Giovanni Battista Hospital, University of Turin, Turin, Italy4 org
7730 t PLoS Medicined : Public Library of Scienceg 11:7, s. e1001680-q 11:7<e1001680-x 1549-1277x 1549-1676
8564 u https://liu.diva-portal.org/smash/get/diva2:741952/FULLTEXT01.pdfx primaryx Raw objecty fulltext:print
8564 u https://journals.plos.org/plosmedicine/article/file?id=10.1371/journal.pmed.1001680&type=printable
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-109985
8564 8u https://doi.org/10.1371/journal.pmed.1001680
8564 8u http://kipublications.ki.se/Default.aspx?queryparsed=id:129629888

Hitta via bibliotek

Till lärosätets databas

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

 
pil uppåt Stäng

Kopiera och spara länken för att återkomma till aktuell vy