WFRF:(Lincoln MR)
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LIBRIS Formathandbok (Information om MARC21)
| Fältnamn | Indikatorer | Metadata |
|---|---|---|
| 000 | 04223naa a2201021 4500 | |
| 001 | oai:prod.swepub.kib.ki.se:140913121 | |
| 003 | SwePub | |
| 008 | 240825s2019 | |||||||||||000 ||eng| | |
| 024 | 7 | a http://kipublications.ki.se/Default.aspx?queryparsed=id:1409131212 URI |
| 024 | 7 | a https://doi.org/10.1038/s41467-019-09773-y2 DOI |
| 040 | a (SwePub)ki | |
| 041 | a engb eng | |
| 042 | 9 SwePub | |
| 072 | 7 | a ref2 swepub-contenttype |
| 072 | 7 | a art2 swepub-publicationtype |
| 100 | 1 | a Madireddy, L4 aut |
| 245 | 1 0 | a A systems biology approach uncovers cell-specific gene regulatory effects of genetic associations in multiple sclerosis |
| 264 | c 2019-05-20 | |
| 264 | 1 | b Springer Science and Business Media LLC,c 2019 |
| 520 | a Genome-wide association studies (GWAS) have identified more than 50,000 unique associations with common human traits. While this represents a substantial step forward, establishing the biology underlying these associations has proven extremely difficult. Even determining which cell types and which particular gene(s) are relevant continues to be a challenge. Here, we conduct a cell-specific pathway analysis of the latest GWAS in multiple sclerosis (MS), which had analyzed a total of 47,351 cases and 68,284 healthy controls and found more than 200 non-MHC genome-wide associations. Our analysis identifies pan immune cell as well as cell-specific susceptibility genes in T cells, B cells and monocytes. Finally, genotype-level data from 2,370 patients and 412 controls is used to compute intra-individual and cell-specific susceptibility pathways that offer a biological interpretation of the individual genetic risk to MS. This approach could be adopted in any other complex trait for which genome-wide data is available. | |
| 700 | 1 | a Patsopoulos, NA4 aut |
| 700 | 1 | a Cotsapas, C4 aut |
| 700 | 1 | a Bos, SD4 aut |
| 700 | 1 | a Beecham, A4 aut |
| 700 | 1 | a McCauley, J4 aut |
| 700 | 1 | a Kim, K4 aut |
| 700 | 1 | a Jia, XM4 aut |
| 700 | 1 | a Santaniello, A4 aut |
| 700 | 1 | a Caillier, SJ4 aut |
| 700 | 1 | a Andlauer, TFM4 aut |
| 700 | 1 | a Barcellos, LF4 aut |
| 700 | 1 | a Berge, T4 aut |
| 700 | 1 | a Bernardinelli, L4 aut |
| 700 | 1 | a Martinelli-Boneschi, F4 aut |
| 700 | 1 | a Booth, DR4 aut |
| 700 | 1 | a Briggs, F4 aut |
| 700 | 1 | a Celius, EG4 aut |
| 700 | 1 | a Comabella, M4 aut |
| 700 | 1 | a Comi, G4 aut |
| 700 | 1 | a Cree, BAC4 aut |
| 700 | 1 | a D'Alfonso, S4 aut |
| 700 | 1 | a Dedham, K4 aut |
| 700 | 1 | a Duquette, P4 aut |
| 700 | 1 | a Efthimios, D4 aut |
| 700 | 1 | a Esposito, F4 aut |
| 700 | 1 | a Fontaine, B4 aut |
| 700 | 1 | a Gasperi, C4 aut |
| 700 | 1 | a Goris, A4 aut |
| 700 | 1 | a Dubois, B4 aut |
| 700 | 1 | a Gourraud, PA4 aut |
| 700 | 1 | a Hadjigeorgiou, G4 aut |
| 700 | 1 | a Haines, J4 aut |
| 700 | 1 | a Hawkins, C4 aut |
| 700 | 1 | a Hemmer, B4 aut |
| 700 | 1 | a Hintzen, R4 aut |
| 700 | 1 | a Horakova, D4 aut |
| 700 | 1 | a Isobe, N4 aut |
| 700 | 1 | a Kalra, S4 aut |
| 700 | 1 | a Kira, J4 aut |
| 700 | 1 | a Khalil, M4 aut |
| 700 | 1 | a Kockum, Iu Karolinska Institutet4 aut |
| 700 | 1 | a Lill, CM4 aut |
| 700 | 1 | a Lincoln, MR4 aut |
| 700 | 1 | a Luessi, F4 aut |
| 700 | 1 | a Martin, R4 aut |
| 700 | 1 | a Oturai, A4 aut |
| 700 | 1 | a Palotie, A4 aut |
| 700 | 1 | a Pericak-Vance, MA4 aut |
| 700 | 1 | a Henry, R4 aut |
| 700 | 1 | a Saarela, J4 aut |
| 700 | 1 | a Ivinson, A4 aut |
| 700 | 1 | a Olsson, Tu Karolinska Institutet4 aut |
| 700 | 1 | a Taylor, BV4 aut |
| 700 | 1 | a Stewart, GJ4 aut |
| 700 | 1 | a Harbo, HF4 aut |
| 700 | 1 | a Compston, A4 aut |
| 700 | 1 | a Hauser, SL4 aut |
| 700 | 1 | a Hafler, DA4 aut |
| 700 | 1 | a Zipp, F4 aut |
| 700 | 1 | a De Jager, P4 aut |
| 700 | 1 | a Sawcer, S4 aut |
| 700 | 1 | a Oksenberg, JR4 aut |
| 700 | 1 | a Baranzini, SE4 aut |
| 710 | 2 | a Karolinska Institutet4 org |
| 773 | 0 | t Nature communicationsd : Springer Science and Business Media LLCg 10:1, s. 2236-q 10:1<2236-x 2041-1723 |
| 856 | 4 | u https://www.nature.com/articles/s41467-019-09773-y.pdf |
| 856 | 4 8 | u http://kipublications.ki.se/Default.aspx?queryparsed=id:140913121 |
| 856 | 4 8 | u https://doi.org/10.1038/s41467-019-09773-y |
Hitta mer i SwePub
- Av författaren/redakt...
- Madireddy, L
- Patsopoulos, NA
- Cotsapas, C
- Bos, SD
- Beecham, A
- McCauley, J
- visa fler...
- Kim, K
- Jia, XM
- Santaniello, A
- Caillier, SJ
- Andlauer, TFM
- Barcellos, LF
- Berge, T
- Bernardinelli, L
- Martinelli-Bones ...
- Booth, DR
- Briggs, F
- Celius, EG
- Comabella, M
- Comi, G
- Cree, BAC
- D'Alfonso, S
- Dedham, K
- Duquette, P
- Efthimios, D
- Esposito, F
- Fontaine, B
- Gasperi, C
- Goris, A
- Dubois, B
- Gourraud, PA
- Hadjigeorgiou, G
- Haines, J
- Hawkins, C
- Hemmer, B
- Hintzen, R
- Horakova, D
- Isobe, N
- Kalra, S
- Kira, J
- Khalil, M
- Kockum, I
- Lill, CM
- Lincoln, MR
- Luessi, F
- Martin, R
- Oturai, A
- Palotie, A
- Pericak-Vance, M ...
- Henry, R
- Saarela, J
- Ivinson, A
- Olsson, T
- Taylor, BV
- Stewart, GJ
- Harbo, HF
- Compston, A
- Hauser, SL
- Hafler, DA
- Zipp, F
- De Jager, P
- Sawcer, S
- Oksenberg, JR
- Baranzini, SE
- visa färre...
- Artiklar i publikationen
- Nature communica ...
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- Karolinska Institutet
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