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Yeast metabolic inn...
Yeast metabolic innovations emerged via expanded metabolic network and gene positive selection
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- Lu, Hongzhong, 1987 (författare)
- Chalmers tekniska högskola,Chalmers University of Technology
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- Li, Feiran, 1993 (författare)
- Chalmers tekniska högskola,Chalmers University of Technology
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- Yuan, Le, 1994 (författare)
- Chalmers tekniska högskola,Chalmers University of Technology
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visa fler...
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- Domenzain Del Castillo Cerecer, Iván, 1991 (författare)
- Chalmers tekniska högskola,Chalmers University of Technology
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- Brown, Rosemary, 1990 (författare)
- Chalmers tekniska högskola,Chalmers University of Technology
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- Wang, Hao, 1975 (författare)
- Chalmers tekniska högskola,Chalmers University of Technology
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- Li, Gang, 1991 (författare)
- Chalmers tekniska högskola,Chalmers University of Technology
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- Chen, Yu, 1990 (författare)
- Chalmers tekniska högskola,Chalmers University of Technology
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- Ji, Boyang, 1983 (författare)
- Chalmers tekniska högskola,Chalmers University of Technology,Danmarks Tekniske Universitet,Technical University of Denmark
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- Kerkhoven, Eduard, 1985 (författare)
- Chalmers tekniska högskola,Chalmers University of Technology
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- Nielsen, Jens B, 1962 (författare)
- BioInnovation Institute (BII),Danmarks Tekniske Universitet,Technical University of Denmark,Chalmers tekniska högskola,Chalmers University of Technology
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(creator_code:org_t)
- 2021-10-22
- 2021
- Engelska.
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Ingår i: Molecular Systems Biology. - : EMBO. - 1744-4292. ; 17:10
- Relaterad länk:
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https://research.cha... (primary) (free)
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https://onlinelibrar...
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https://doi.org/10.1...
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https://research.cha...
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Abstract
Ämnesord
Stäng
- Yeasts are known to have versatile metabolic traits, while how these metabolic traits have evolved has not been elucidated systematically. We performed integrative evolution analysis to investigate how genomic evolution determines trait generation by reconstructing genome-scale metabolic models (GEMs) for 332 yeasts. These GEMs could comprehensively characterize trait diversity and predict enzyme functionality, thereby signifying that sequence-level evolution has shaped reaction networks towards new metabolic functions. Strikingly, using GEMs, we can mechanistically map different evolutionary events, e.g. horizontal gene transfer and gene duplication, onto relevant subpathways to explain metabolic plasticity. This demonstrates that gene family expansion and enzyme promiscuity are prominent mechanisms for metabolic trait gains, while GEM simulations reveal that additional factors, such as gene loss from distant pathways, contribute to trait losses. Furthermore, our analysis could pinpoint to specific genes and pathways that have been under positive selection and relevant for the formulation of complex metabolic traits, i.e. thermotolerance and the Crabtree effect. Our findings illustrate how multidimensional evolution in both metabolic network structure and individual enzymes drives phenotypic variations.
Ämnesord
- NATURVETENSKAP -- Biologi -- Evolutionsbiologi (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences -- Evolutionary Biology (hsv//eng)
- NATURVETENSKAP -- Biologi -- Bioinformatik och systembiologi (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences -- Bioinformatics and Systems Biology (hsv//eng)
- NATURVETENSKAP -- Biologi -- Genetik (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences -- Genetics (hsv//eng)
Nyckelord
- genome analysis
- metabolic innovation
- systems biology
- genome-scale metabolic models
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Hitta via bibliotek
Till lärosätets databas
- Av författaren/redakt...
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Lu, Hongzhong, 1 ...
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Li, Feiran, 1993
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Yuan, Le, 1994
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Domenzain Del Ca ...
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Brown, Rosemary, ...
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Wang, Hao, 1975
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visa fler...
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Li, Gang, 1991
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Chen, Yu, 1990
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Ji, Boyang, 1983
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Kerkhoven, Eduar ...
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Nielsen, Jens B, ...
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visa färre...
- Om ämnet
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- NATURVETENSKAP
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NATURVETENSKAP
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och Biologi
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och Evolutionsbiolog ...
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- NATURVETENSKAP
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NATURVETENSKAP
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och Biologi
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och Bioinformatik oc ...
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- NATURVETENSKAP
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NATURVETENSKAP
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och Biologi
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och Genetik
- Artiklar i publikationen
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Molecular System ...
- Av lärosätet
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Chalmers tekniska högskola