WFRF:(Malmberg M)
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| Fältnamn | Indikatorer | Metadata |
|---|---|---|
| 000 | 06404naa a2200757 4500 | |
| 001 | oai:DiVA.org:liu-95969 | |
| 003 | SwePub | |
| 008 | 130812s2013 | |||||||||||000 ||eng| | |
| 009 | oai:lup.lub.lu.se:3a5f9097-c51c-4122-811c-b617377218b5 | |
| 009 | oai:prod.swepub.kib.ki.se:126909602 | |
| 009 | oai:DiVA.org:uu-205379 | |
| 024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-959692 URI |
| 024 | 7 | a https://doi.org/10.1007/s10549-013-2579-x2 DOI |
| 024 | 7 | a https://lup.lub.lu.se/record/39791362 URI |
| 024 | 7 | a http://kipublications.ki.se/Default.aspx?queryparsed=id:1269096022 URI |
| 024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-2053792 URI |
| 040 | a (SwePub)liud (SwePub)lud (SwePub)kid (SwePub)uu | |
| 041 | a engb eng | |
| 042 | 9 SwePub | |
| 072 | 7 | a ref2 swepub-contenttype |
| 072 | 7 | a art2 swepub-publicationtype |
| 100 | 1 | a Bjohle, Ju Karolinska Institutet,Karolinska Institute, Sweden4 aut |
| 245 | 1 0 | a Serum thymidine kinase activity compared with CA 15-3 in locally advanced and metastatic breast cancer within a randomized trial |
| 264 | c 2013-06-05 | |
| 264 | 1 | b Springer Verlag (Germany),c 2013 |
| 338 | a print2 rdacarrier | |
| 500 | a Funding Agencies|Swedish Cancer Society||Stockholm Cancer Society||King Gustav V Jubilee Fund||Swedish Research Council||Stockholm City Council||Karolinska Institutet||Stockholm County Council Research Strategy Committee||BRECT||Swedish Breast Cancer Association||Marit and Hans Rausings Initiative Against Breast Cancer||Karolinska Institutet Research Funds||Biovica International AB|| | |
| 520 | a The primary objective was to estimate serum thymidine kinase 1 (TK1) activity, reflecting total body cell proliferation rate including cancer cell proliferation, in women with loco regional inoperable or metastatic breast cancer participating in a prospective and randomized study. Secondary objectives were to analyze TK1 in relation to progression-free survival (PFS), overall survival (OS), therapy response and other tumour characteristics, including CA 15-3, widely used as a standard serum marker for disease progression. TK1 and CA 15-3 were analysed in 198 serum samples collected prospectively from women included in the randomized TEX trial between December 2002 and June 2007. TK1 activity was determined by the ELISA based DiviTum (TM) assay, and CA 15-3 analyses was generated with the electrochemiluminescence immunoassay Cobas Elecsys CA 15-3 II. High pre-treatment TK1 activity predicted shorter PFS (10 vs. 15 months p = 0.02) and OS (21 vs. 38 months, p andlt; 0.0001), respectively. After adjustment for age, metastatic site and study treatment TK1 showed a trend as predictor of PFS (p = 0.059) and was an independent prognostic factor for OS, (HR 1.81, 95 % confidence interval (CI) 1.26-2.61, p = 0.001). There was a trend of shortened OS for women with high CA 15-3 (p = 0.054) in univariate analysis, but not after adjustment for the above mentioned covariates. Both TK1 (p = 0.0011) and CA 15-3 (p = 0.0004) predicted response to treatment. There were statistically different distributions of TK1 and CA 15-3 in relation to the site of metastases. TK1 activity measured by DiviTum (TM) predicted therapy response, PFS and OS in loco regional inoperable or disseminated breast cancer. These results suggest that this factor is a useful serum marker. In the present material, a prognostic value of CA 15-3 could not be proven. | |
| 650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Cancer och onkologi0 (SwePub)302032 hsv//swe |
| 650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Cancer and Oncology0 (SwePub)302032 hsv//eng |
| 653 | a TK1 | |
| 653 | a CA 15-3 | |
| 653 | a Breast cancer | |
| 653 | a Prognostic factor | |
| 653 | a Predictive factor | |
| 653 | a DiviTum | |
| 653 | a MEDICINE | |
| 653 | a MEDICIN | |
| 653 | a TK1 | |
| 653 | a CA 15-3 | |
| 653 | a Breast cancer | |
| 653 | a Prognostic factor | |
| 653 | a Predictive factor | |
| 653 | a DiviTum | |
| 700 | 1 | a Bergqvist, Ju Karolinska Institutet,Karolinska Institute, Sweden4 aut |
| 700 | 1 | a Gronowitz, J. Simonu Uppsala universitet,Klinisk virologi,Biov Int AB, Sweden4 aut0 (Swepub:uu)simongro |
| 700 | 1 | a Johansson, Hu Karolinska Institutet,Karolinska Institute, Sweden4 aut |
| 700 | 1 | a Carlsson, Lu Sundsvall Gen Hospital, Sweden4 aut |
| 700 | 1 | a Einbeigi, Zu Sahlgrens University Hospital, Sweden4 aut |
| 700 | 1 | a Linderholm, Bu Karolinska Institutet,Sahlgrens University Hospital, Sweden4 aut |
| 700 | 1 | a Loman, Niklasu Lund University,Lunds universitet,Bröstcancer-genetik,Sektion I,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Breastcancer-genetics,Section I,Department of Clinical Sciences, Lund,Faculty of Medicine,Lund University, Sweden4 aut0 (Swepub:lu)onk-nlo |
| 700 | 1 | a Malmberg, Mu Helsingborg Gen Hospital, Sweden,Lund University, Sweden,Kalmar Gen Hospital, Sweden4 aut |
| 700 | 1 | a Soderberg, Mu Lund University, Sweden4 aut |
| 700 | 1 | a Sundquist, Mu Kalmar Gen Hospital, Sweden4 aut |
| 700 | 1 | a Walz, Thomasu Östergötlands Läns Landsting,Linköpings universitet,Avdelningen för kliniska vetenskaper,Hälsouniversitetet,Onkologiska kliniken US,Karolinska Institute, Sweden4 aut0 (Swepub:liu)thowa08 |
| 700 | 1 | a Fernö, Mårtenu Lund University,Lunds universitet,Bröstcancer-genetik,Sektion I,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Breastcancer-genetics,Section I,Department of Clinical Sciences, Lund,Faculty of Medicine4 aut0 (Swepub:lu)onk-mfe |
| 700 | 1 | a Bergh, Ju Karolinska Institutet,Karolinska Institute, Sweden4 aut |
| 700 | 1 | a Hatschek, Tu Karolinska Institutet,Karolinska Institute, Sweden4 aut |
| 710 | 2 | a Karolinska Institutetb Karolinska Institute, Sweden4 org |
| 773 | 0 | t Breast Cancer Research and Treatmentd : Springer Verlag (Germany)g 139:3, s. 751-758q 139:3<751-758x 0167-6806x 1573-7217 |
| 856 | 4 | u http://dx.doi.org/10.1007/s10549-013-2579-xy FULLTEXT |
| 856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-95969 |
| 856 | 4 8 | u https://doi.org/10.1007/s10549-013-2579-x |
| 856 | 4 8 | u https://lup.lub.lu.se/record/3979136 |
| 856 | 4 8 | u http://kipublications.ki.se/Default.aspx?queryparsed=id:126909602 |
| 856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-205379 |
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