WFRF:(Mandahl N)
Sökning: WFRF:(Mandahl N) > Analysis of the dis...
LIBRIS Formathandbok (Information om MARC21)
| Fältnamn | Indikatorer | Metadata |
|---|---|---|
| 000 | 05762naa a2200649 4500 | |
| 001 | oai:lup.lub.lu.se:a1eaf076-050a-40f6-bf06-b2313279f554 | |
| 003 | SwePub | |
| 008 | 160401s2001 | |||||||||||000 ||eng| | |
| 024 | 7 | a https://lup.lub.lu.se/record/11201032 URI |
| 024 | 7 | a https://doi.org/10.1016/S0165-4608(01)00488-52 DOI |
| 040 | a (SwePub)lu | |
| 041 | a engb eng | |
| 042 | 9 SwePub | |
| 072 | 7 | a art2 swepub-publicationtype |
| 072 | 7 | a ref2 swepub-contenttype |
| 100 | 1 | a Dahlén, Au Lund University,Lunds universitet,Avdelningen för klinisk genetik,Institutionen för laboratoriemedicin,Medicinska fakulteten,Division of Clinical Genetics,Department of Laboratory Medicine,Faculty of Medicine4 aut0 (Swepub:lu)extLU-455 |
| 245 | 1 0 | a Analysis of the distribution and frequency of trisomy 7 in vivo in synovia from patients with osteoarthritis and pigmented villonodular synovitis |
| 264 | 1 | c 2001 |
| 300 | a 6 s. | |
| 520 | a Osteoarthritis (OA) and pigmented villonodular synovitis (PVNS) are disorders associated with trisomy 7. The aim of the present study was to determine the frequency and distribution of the cells with +7 in vivo by analyzing sections of paraffin-embedded synovia from patients affected by OA, PVNS, other forms of synovitis [hemorragic synovitis (HS) and chronic synovitis (CS)], and from individuals without joint disease. Fluorescence in situ hybridization (FISH), using a centromeric probe for chromosome 7, showed that the mean frequency of trisomic nuclei in 5-microm sections was highest in PVNS (9.0%), followed by CS (5.9%), OA (5.6%), and HS (4.6%), whereas trisomic nuclei were rare (0.7%) in normal tissue. When 8-microm sections were studied, the frequencies of trisomic cells in OA and control synovia increased to 6.7% and 1.5%, respectively. Trisomic nuclei were found in all cases, including those for which cytogenetic analysis of short-term cultures had not disclosed any trisomic cells. Overall, the trisomic cells were scattered within the tissue. However, small clusters of cells with +7 were found in three cases. By hematoxylin-eosin staining of the slides used for FISH analysis it could be shown that the clustered trisomic cells were proliferating synoviocytes within villous extensions of the synovial membrane. | |
| 650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Hälsovetenskapx Arbetsmedicin och miljömedicin0 (SwePub)303032 hsv//swe |
| 650 | 7 | a MEDICAL AND HEALTH SCIENCESx Health Sciencesx Occupational Health and Environmental Health0 (SwePub)303032 hsv//eng |
| 650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Cancer och onkologi0 (SwePub)302032 hsv//swe |
| 650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Cancer and Oncology0 (SwePub)302032 hsv//eng |
| 650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Ortopedi0 (SwePub)302112 hsv//swe |
| 650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Orthopaedics0 (SwePub)302112 hsv//eng |
| 650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Medicinska och farmaceutiska grundvetenskaperx Medicinsk genetik0 (SwePub)301072 hsv//swe |
| 650 | 7 | a MEDICAL AND HEALTH SCIENCESx Basic Medicinex Medical Genetics0 (SwePub)301072 hsv//eng |
| 653 | a Adult | |
| 653 | a Aged | |
| 653 | a Aged, 80 and over | |
| 653 | a Cell Count | |
| 653 | a Chromosomes, Human, Pair 7 | |
| 653 | a Data Interpretation, Statistical | |
| 653 | a Female | |
| 653 | a Humans | |
| 653 | a In Situ Hybridization, Fluorescence | |
| 653 | a Karyotyping | |
| 653 | a Male | |
| 653 | a Middle Aged | |
| 653 | a Osteoarthritis | |
| 653 | a Synovial Fluid | |
| 653 | a Synovitis, Pigmented Villonodular | |
| 653 | a Trisomy | |
| 653 | a Journal Article | |
| 653 | a Research Support, Non-U.S. Gov't | |
| 700 | 1 | a Broberg, Ku Lund University,Lunds universitet,Avdelningen för klinisk genetik,Institutionen för laboratoriemedicin,Medicinska fakulteten,Division of Clinical Genetics,Department of Laboratory Medicine,Faculty of Medicine4 aut0 (Swepub:lu)kgen-kbr |
| 700 | 1 | a Domanski, H Au Lund University,Lunds universitet,Tumörmikromiljö,Sektion I,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Tumor microenvironment,Section I,Department of Clinical Sciences, Lund,Faculty of Medicine4 aut0 (Swepub:lu)pat-hdo |
| 700 | 1 | a Toksvig-Larsen, Su Lund University,Lunds universitet,Ortopedi, Lund,Sektion III,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Orthopaedics (Lund),Section III,Department of Clinical Sciences, Lund,Faculty of Medicine4 aut0 (Swepub:lu)ort-stl |
| 700 | 1 | a Lindstrand, Au Lund University,Lunds universitet,Ortopedi, Lund,Sektion III,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Orthopaedics (Lund),Section III,Department of Clinical Sciences, Lund,Faculty of Medicine4 aut0 (Swepub:lu)ort-ali |
| 700 | 1 | a Mandahl, Nu Lund University,Lunds universitet,Avdelningen för klinisk genetik,Institutionen för laboratoriemedicin,Medicinska fakulteten,Division of Clinical Genetics,Department of Laboratory Medicine,Faculty of Medicine4 aut0 (Swepub:lu)kgen-nma |
| 700 | 1 | a Mertens, Fu Lund University,Lunds universitet,Avdelningen för klinisk genetik,Institutionen för laboratoriemedicin,Medicinska fakulteten,Division of Clinical Genetics,Department of Laboratory Medicine,Faculty of Medicine4 aut0 (Swepub:lu)kgen-fme |
| 710 | 2 | a Avdelningen för klinisk genetikb Institutionen för laboratoriemedicin4 org |
| 773 | 0 | t Cancer Genetics and Cytogeneticsg 131:1, s. 19-24q 131:1<19-24x 0165-4608 |
| 856 | 4 | u http://dx.doi.org/10.1016/S0165-4608(01)00488-5y FULLTEXT |
| 856 | 4 8 | u https://lup.lub.lu.se/record/1120103 |
| 856 | 4 8 | u https://doi.org/10.1016/S0165-4608(01)00488-5 |
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