WFRF:(McInnis M. G.)
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| Fältnamn | Indikatorer | Metadata |
|---|---|---|
| 000 | 12106naa a2202629 4500 | |
| 001 | oai:gup.ub.gu.se/311155 | |
| 003 | SwePub | |
| 008 | 240528s2021 | |||||||||||000 ||eng| | |
| 009 | oai:DiVA.org:umu-187672 | |
| 009 | oai:prod.swepub.kib.ki.se:148247662 | |
| 024 | 7 | a https://gup.ub.gu.se/publication/3111552 URI |
| 024 | 7 | a https://doi.org/10.1192/bjp.2021.1022 DOI |
| 024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-1876722 URI |
| 024 | 7 | a http://kipublications.ki.se/Default.aspx?queryparsed=id:1482476622 URI |
| 040 | a (SwePub)gud (SwePub)umud (SwePub)ki | |
| 041 | a eng | |
| 042 | 9 SwePub | |
| 072 | 7 | a ref2 swepub-contenttype |
| 072 | 7 | a art2 swepub-publicationtype |
| 100 | 1 | a Jonsson, Lina,d 1982u Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry4 aut0 (Swepub:gu)xjliny |
| 245 | 1 0 | a Characterisation of age and polarity at onset in bipolar disorder |
| 264 | c 2021-08-25 | |
| 264 | 1 | b Royal College of Psychiatrists,c 2021 |
| 520 | a Background Studying phenotypic and genetic characteristics of age at onset (AAO) and polarity at onset (PAO) in bipolar disorder can provide new insights into disease pathology and facilitate the development of screening tools. Aims To examine the genetic architecture of AAO and PAO and their association with bipolar disorder disease characteristics. Method Genome-wide association studies (GWASs) and polygenic score (PGS) analyses of AAO (n = 12 977) and PAO (n = 6773) were conducted in patients with bipolar disorder from 34 cohorts and a replication sample (n = 2237). The association of onset with disease characteristics was investigated in two of these cohorts. Results Earlier AAO was associated with a higher probability of psychotic symptoms, suicidality, lower educational attainment, not living together and fewer episodes. Depressive onset correlated with suicidality and manic onset correlated with delusions and manic episodes. Systematic differences in AAO between cohorts and continents of origin were observed. This was also reflected in single-nucleotide variant-based heritability estimates, with higher heritabilities for stricter onset definitions. Increased PGS for autism spectrum disorder (beta = -0.34 years, s.e. = 0.08), major depression (beta = -0.34 years, s.e. = 0.08), schizophrenia (beta = -0.39 years, s.e. = 0.08), and educational attainment (beta = -0.31 years, s.e. = 0.08) were associated with an earlier AAO. The AAO GWAS identified one significant locus, but this finding did not replicate. Neither GWAS nor PGS analyses yielded significant associations with PAO. Conclusions AAO and PAO are associated with indicators of bipolar disorder severity. Individuals with an earlier onset show an increased polygenic liability for a broad spectrum of psychiatric traits. Systematic differences in AAO across cohorts, continents and phenotype definitions introduce significant heterogeneity, affecting analyses. | |
| 650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Medicinska och farmaceutiska grundvetenskaperx Neurovetenskaper0 (SwePub)301052 hsv//swe |
| 650 | 7 | a MEDICAL AND HEALTH SCIENCESx Basic Medicinex Neurosciences0 (SwePub)301052 hsv//eng |
| 650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Psykiatri0 (SwePub)302152 hsv//swe |
| 650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Psychiatry0 (SwePub)302152 hsv//eng |
| 653 | a Bipolar disorder | |
| 653 | a age at onset | |
| 653 | a polarity at onset | |
| 653 | a GWAS | |
| 653 | a polygenic score | |
| 653 | a genome-wide association | |
| 653 | a illness | |
| 653 | a genetics | |
| 653 | a disease | |
| 653 | a family | |
| 653 | a loci | |
| 653 | a Psychiatry | |
| 653 | a Age at onset | |
| 700 | 1 | a Landén, Mikael,d 1966u Gothenburg University,Göteborgs universitet,Karolinska Institutet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry4 aut0 (Swepub:gu)xlandt |
| 700 | 1 | a Vreeker, A.4 aut |
| 700 | 1 | a McQuillin, A.4 aut |
| 700 | 1 | a Stahl, E. A.4 aut |
| 700 | 1 | a Ruderfer, D.4 aut |
| 700 | 1 | a Grigoroiu-Serbanescu, M.4 aut |
| 700 | 1 | a Panagiotaropoulou, G.4 aut |
| 700 | 1 | a Ripke, S.4 aut |
| 700 | 1 | a Bigdeli, T. B.4 aut |
| 700 | 1 | a Stein, F.4 aut |
| 700 | 1 | a Meller, T.4 aut |
| 700 | 1 | a Meinert, S.4 aut |
| 700 | 1 | a Pelin, H.4 aut |
| 700 | 1 | a Streit, F.4 aut |
| 700 | 1 | a Papiol, S.4 aut |
| 700 | 1 | a Adams, M. J.4 aut |
| 700 | 1 | a Adolfsson, Rolfu Umeå universitet,Psykiatri4 aut0 (Swepub:umu)road0001 |
| 700 | 1 | a Adorjan, K.4 aut |
| 700 | 1 | a Agartz, I.u Karolinska Institutet4 aut |
| 700 | 1 | a Aminoff, S. R.4 aut |
| 700 | 1 | a Anderson-Schmidt, H.4 aut |
| 700 | 1 | a Andreassen, O. A.4 aut |
| 700 | 1 | a Ardau, R.4 aut |
| 700 | 1 | a Aubry, J. M.4 aut |
| 700 | 1 | a Balaban, C.4 aut |
| 700 | 1 | a Bass, N.4 aut |
| 700 | 1 | a Baune, B. T.4 aut |
| 700 | 1 | a Bellivier, F.4 aut |
| 700 | 1 | a Benabarre, A.4 aut |
| 700 | 1 | a Bengesser, S.4 aut |
| 700 | 1 | a Berrettini, W. H.4 aut |
| 700 | 1 | a Boks, M. P.4 aut |
| 700 | 1 | a Bromet, E. J.4 aut |
| 700 | 1 | a Brosch, K.4 aut |
| 700 | 1 | a Budde, M.4 aut |
| 700 | 1 | a Byerley, W.4 aut |
| 700 | 1 | a Cervantes, P.4 aut |
| 700 | 1 | a Chillotti, C.4 aut |
| 700 | 1 | a Cichon, S.4 aut |
| 700 | 1 | a Clark, S. R.4 aut |
| 700 | 1 | a Comes, A. L.4 aut |
| 700 | 1 | a Corvin, A.4 aut |
| 700 | 1 | a Coryell, W.4 aut |
| 700 | 1 | a Craddock, N.4 aut |
| 700 | 1 | a Craig, D. W.4 aut |
| 700 | 1 | a Pålsson, Erik,d 1975u Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry4 aut0 (Swepub:gu)xpaler |
| 700 | 1 | a Cruceanu, C.4 aut |
| 700 | 1 | a Czerski, P. M.4 aut |
| 700 | 1 | a Dalkner, N.4 aut |
| 700 | 1 | a Dannlowski, U.4 aut |
| 700 | 1 | a Degenhardt, F.4 aut |
| 700 | 1 | a Del Zompo, M.4 aut |
| 700 | 1 | a DePaulo, J. R.4 aut |
| 700 | 1 | a Djurovic, S.4 aut |
| 700 | 1 | a Edenberg, H. J.4 aut |
| 700 | 1 | a Al Eissa, M.4 aut |
| 700 | 1 | a Elvsashagen, T.4 aut |
| 700 | 1 | a Etain, B.4 aut |
| 700 | 1 | a Fanous, A. H.4 aut |
| 700 | 1 | a Fellendorf, F.4 aut |
| 700 | 1 | a Fiorentino, A.4 aut |
| 700 | 1 | a Forstner, A. J.4 aut |
| 700 | 1 | a Frye, M. A.4 aut |
| 700 | 1 | a Fullerton, J. M.4 aut |
| 700 | 1 | a Gade, K.4 aut |
| 700 | 1 | a Garnham, J.4 aut |
| 700 | 1 | a Gershon, E.4 aut |
| 700 | 1 | a Gill, M.4 aut |
| 700 | 1 | a Goes, F. S.4 aut |
| 700 | 1 | a Gordon-Smith, K.4 aut |
| 700 | 1 | a Grof, P.4 aut |
| 700 | 1 | a Guzman-Parra, J.4 aut |
| 700 | 1 | a Hahn, T.4 aut |
| 700 | 1 | a Hasler, R.4 aut |
| 700 | 1 | a Heilbronner, M.4 aut |
| 700 | 1 | a Heilbronner, U.4 aut |
| 700 | 1 | a Jamain, S.4 aut |
| 700 | 1 | a Jimenez, E.4 aut |
| 700 | 1 | a Jones, I.4 aut |
| 700 | 1 | a Jones, L.4 aut |
| 700 | 1 | a Jonsson, Lina,d 1982u Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry4 aut0 (Swepub:gu)xjliny |
| 700 | 1 | a Kahn, R. S.4 aut |
| 700 | 1 | a Kelsoe, J. R.4 aut |
| 700 | 1 | a Kennedy, J. L.4 aut |
| 700 | 1 | a Kircher, T.4 aut |
| 700 | 1 | a Kirov, G.4 aut |
| 700 | 1 | a Kittel-Schneider, S.4 aut |
| 700 | 1 | a Klohn-Saghatolislam, F.4 aut |
| 700 | 1 | a Knowles, J. A.4 aut |
| 700 | 1 | a Kranz, T. M.4 aut |
| 700 | 1 | a Lagerberg, T. V.4 aut |
| 700 | 1 | a Landén, Mikael,d 1966u Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry4 aut0 (Swepub:gu)xlandt |
| 700 | 1 | a Lawson, W. B.4 aut |
| 700 | 1 | a Leboyer, M.4 aut |
| 700 | 1 | a Li, Q. Q. S.4 aut |
| 700 | 1 | a Maj, M.4 aut |
| 700 | 1 | a Malaspina, D.4 aut |
| 700 | 1 | a Manchia, M.4 aut |
| 700 | 1 | a Mayoral, F.4 aut |
| 700 | 1 | a McElroy, S. L.4 aut |
| 700 | 1 | a McInnis, M. G.4 aut |
| 700 | 1 | a McIntosh, A. M.4 aut |
| 700 | 1 | a Medeiros, H.4 aut |
| 700 | 1 | a Melle, I.4 aut |
| 700 | 1 | a Milanova, V.4 aut |
| 700 | 1 | a Mitchell, P. B.4 aut |
| 700 | 1 | a Monteleone, P.4 aut |
| 700 | 1 | a Monteleone, A. M.4 aut |
| 700 | 1 | a Nothen, M. M.4 aut |
| 700 | 1 | a Novak, T.4 aut |
| 700 | 1 | a Nurnberger, J. I.4 aut |
| 700 | 1 | a O'Brien, N.4 aut |
| 700 | 1 | a O'Connell, K. S.4 aut |
| 700 | 1 | a O'Donovan, C.4 aut |
| 700 | 1 | a O'Donovan, M. C.4 aut |
| 700 | 1 | a Opel, N.4 aut |
| 700 | 1 | a Ortiz, A.4 aut |
| 700 | 1 | a Owen, M. J.4 aut |
| 700 | 1 | a Pålsson, Erik,d 1975u Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry4 aut0 (Swepub:gu)xpaler |
| 700 | 1 | a Pato, C.4 aut |
| 700 | 1 | a Pato, M. T.4 aut |
| 700 | 1 | a Pawlak, J.4 aut |
| 700 | 1 | a Pfarr, J. K.4 aut |
| 700 | 1 | a Pisanu, C.4 aut |
| 700 | 1 | a Potash, J. B.4 aut |
| 700 | 1 | a Rapaport, M. H.4 aut |
| 700 | 1 | a Reich-Erkelenz, D.4 aut |
| 700 | 1 | a Reif, A.4 aut |
| 700 | 1 | a Reininghaus, E.4 aut |
| 700 | 1 | a Repple, J.4 aut |
| 700 | 1 | a Richard-Lepouriel, H.4 aut |
| 700 | 1 | a Rietschel, M.4 aut |
| 700 | 1 | a Ringwald, K.4 aut |
| 700 | 1 | a Roberts, G.4 aut |
| 700 | 1 | a Rouleau, G.4 aut |
| 700 | 1 | a Schaupp, S.4 aut |
| 700 | 1 | a Scheftner, W. A.4 aut |
| 700 | 1 | a Schmitt, S.4 aut |
| 700 | 1 | a Schofield, P. R.4 aut |
| 700 | 1 | a Schubert, K. O.4 aut |
| 700 | 1 | a Schulte, E. C.4 aut |
| 700 | 1 | a Schweizer, B.4 aut |
| 700 | 1 | a Senner, F.4 aut |
| 700 | 1 | a Severino, G.4 aut |
| 700 | 1 | a Sharp, S.4 aut |
| 700 | 1 | a Slaney, C.4 aut |
| 700 | 1 | a Smeland, O. B.4 aut |
| 700 | 1 | a Sobell, J. L.4 aut |
| 700 | 1 | a Squassina, A.4 aut |
| 700 | 1 | a Stopkova, P.4 aut |
| 700 | 1 | a Strauss, J.4 aut |
| 700 | 1 | a Tortorella, A.4 aut |
| 700 | 1 | a Turecki, G.4 aut |
| 700 | 1 | a Twarowska-Hauser, J.4 aut |
| 700 | 1 | a Veldic, M.4 aut |
| 700 | 1 | a Vieta, E.4 aut |
| 700 | 1 | a Vincent, J. B.4 aut |
| 700 | 1 | a Xu, W.4 aut |
| 700 | 1 | a Zai, C. C.4 aut |
| 700 | 1 | a Zandi, P. P.4 aut |
| 700 | 1 | a Di Florio, A.4 aut |
| 700 | 1 | a Smoller, J. W.4 aut |
| 700 | 1 | a Biernacka, J. M.4 aut |
| 700 | 1 | a McMahon, F. J.4 aut |
| 700 | 1 | a Alda, M.4 aut |
| 700 | 1 | a Muller-Myhsok, B.4 aut |
| 700 | 1 | a Koutsouleris, N.4 aut |
| 700 | 1 | a Falkai, P.4 aut |
| 700 | 1 | a Freimer, N. B.4 aut |
| 700 | 1 | a Andlauer, T. F. M.4 aut |
| 700 | 1 | a Schulze, T. G.4 aut |
| 700 | 1 | a Ophoff, R. A.4 aut |
| 710 | 2 | a Göteborgs universitetb Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi4 org |
| 773 | 0 | t British Journal of Psychiatryd : Royal College of Psychiatristsg 219:6, s. 659-669q 219:6<659-669x 0007-1250x 1472-1465 |
| 856 | 4 | u https://www.cambridge.org/core/services/aop-cambridge-core/content/view/DBFE4929435DBD6D75BC546201BC4BA1/S0007125021001021a.pdf/div-class-title-characterisation-of-age-and-polarity-at-onset-in-bipolar-disorder-div.pdf |
| 856 | 4 | u https://doi.org/10.1192/bjp.2021.102y Fulltext |
| 856 | 4 | u https://umu.diva-portal.org/smash/get/diva2:1595817/FULLTEXT02.pdfx primaryx Raw objecty fulltext:print |
| 856 | 4 8 | u https://gup.ub.gu.se/publication/311155 |
| 856 | 4 8 | u https://doi.org/10.1192/bjp.2021.102 |
| 856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-187672 |
| 856 | 4 8 | u http://kipublications.ki.se/Default.aspx?queryparsed=id:148247662 |
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- Ruderfer, D.
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- Grigoroiu-Serban ...
- Panagiotaropoulo ...
- Ripke, S.
- Bigdeli, T. B.
- Stein, F.
- Meller, T.
- Meinert, S.
- Pelin, H.
- Streit, F.
- Papiol, S.
- Adams, M. J.
- Adolfsson, Rolf
- Adorjan, K.
- Agartz, I.
- Aminoff, S. R.
- Anderson-Schmidt ...
- Andreassen, O. A ...
- Ardau, R.
- Aubry, J. M.
- Balaban, C.
- Bass, N.
- Baune, B. T.
- Bellivier, F.
- Benabarre, A.
- Bengesser, S.
- Berrettini, W. H ...
- Boks, M. P.
- Bromet, E. J.
- Brosch, K.
- Budde, M.
- Byerley, W.
- Cervantes, P.
- Chillotti, C.
- Cichon, S.
- Clark, S. R.
- Comes, A. L.
- Corvin, A.
- Coryell, W.
- Craddock, N.
- Craig, D. W.
- Pålsson, Erik, 1 ...
- Cruceanu, C.
- Czerski, P. M.
- Dalkner, N.
- Dannlowski, U.
- Degenhardt, F.
- Del Zompo, M.
- DePaulo, J. R.
- Djurovic, S.
- Edenberg, H. J.
- Al Eissa, M.
- Elvsashagen, T.
- Etain, B.
- Fanous, A. H.
- Fellendorf, F.
- Fiorentino, A.
- Forstner, A. J.
- Frye, M. A.
- Fullerton, J. M.
- Gade, K.
- Garnham, J.
- Gershon, E.
- Gill, M.
- Goes, F. S.
- Gordon-Smith, K.
- Grof, P.
- Guzman-Parra, J.
- Hahn, T.
- Hasler, R.
- Heilbronner, M.
- Heilbronner, U.
- Jamain, S.
- Jimenez, E.
- Jones, I.
- Jones, L.
- Kahn, R. S.
- Kelsoe, J. R.
- Kennedy, J. L.
- Kircher, T.
- Kirov, G.
- Kittel-Schneider ...
- Klohn-Saghatolis ...
- Knowles, J. A.
- Kranz, T. M.
- Lagerberg, T. V.
- Lawson, W. B.
- Leboyer, M.
- Li, Q. Q. S.
- Maj, M.
- Malaspina, D.
- Manchia, M.
- Mayoral, F.
- McElroy, S. L.
- McInnis, M. G.
- McIntosh, A. M.
- Medeiros, H.
- Melle, I.
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- Mitchell, P. B.
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- Novak, T.
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