Search: WFRF:(Merrill David)
> (2015-2019) >
Nitrated nucleosome...
Nitrated nucleosome levels and neuropsychiatric events in systemic lupus erythematosus; a multi-center retrospective case-control study
-
- Ferreira, Isabel (author)
- University College London
-
- Croca, Sara (author)
- University College London
-
- Raimondo, Maria Gabriella (author)
- University College London
-
show more...
-
- Matharu, Manjit (author)
- University College London
-
- Miller, Sarah (author)
- University College London
-
- Giles, Ian (author)
- University College London
-
- Isenberg, David (author)
- University College London
-
- Ioannou, Yiannis (author)
- University College London
-
- Hanly, John G. (author)
- Dalhousie University
-
- Urowitz, Murray B. (author)
- University of Toronto
-
- Anderson, Nicole (author)
- University of Toronto
-
- Aranow, Cynthia (author)
- Feinstein Institute for Medical Research
-
- Askanase, Anca (author)
- Columbia University
-
- Bae, Sang Cheol (author)
- Hanyang University
-
- Bernatsky, Sasha (author)
- McGill University Health Center
-
- Bruce, Ian N. (author)
- University of Manchester
-
Buyon, Jill (author)
-
- Clarke, Ann E. (author)
- University of Calgary
-
- Dooley, Mary Anne (author)
- University of North Carolina
-
- Fortin, Paul (author)
- Centre Hospitalier de l'Universite Laval (CHUL)
-
Ginzler, Ellen (author)
-
- Gladman, Dafna (author)
- University of Toronto
-
- Gordon, Caroline (author)
- University of Birmingham
-
- Inanc, Murat (author)
- Istanbul University
-
- Jacobsen, Søren (author)
- Copenhagen University Hospital
-
Kalunian, Kenneth (author)
-
Kamen, Diane (author)
-
- Khamashta, Munther (author)
- King's College London
-
- Lim, Sam (author)
- Emory University
-
Manzi, Susan (author)
-
- Merrill, Joan (author)
- Oklahoma Medical Research Foundation
-
- Nived, Ola (author)
- Lund University,Lunds universitet,Reumatologi och molekylär skelettbiologi,Sektion III,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Rheumatology,Section III,Department of Clinical Sciences, Lund,Faculty of Medicine
-
- Peschken, Christine (author)
- University of Manitoba
-
- Petri, Michelle (author)
- Johns Hopkins University School of Medicine
-
- Ramsey-Goldman, Rosalind (author)
- Northwestern University Feinberg School of Medicine
-
- Ruiz-Irastorza, Guillermo (author)
- University of the Basque Country
-
- Sanchez-Guerrero, Jorge (author)
- University of Toronto
-
- Steinson, Kristjan (author)
- National University Hospital of Iceland
-
- Sturfelt, Gunnar K. (author)
- Lund University,Lunds universitet,Reumatologi och molekylär skelettbiologi,Sektion III,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Rheumatology,Section III,Department of Clinical Sciences, Lund,Faculty of Medicine
-
- van Vollenhoven, Ronald (author)
- Karolinska Institutet
-
- Wallace, Daniel J. (author)
- Jonsson Comprehensive Cancer Center
-
- Zoma, Asad (author)
- Hairmyres Hospital
-
- Rahman, Anisur (author)
- University College London
-
show less...
-
(creator_code:org_t)
- 2017-12-22
- 2017
- English.
-
In: Arthritis Research and Therapy. - : Springer Science and Business Media LLC. - 1478-6354 .- 1478-6362. ; 19:1
- Related links:
-
http://dx.doi.org/10... (free)
-
show more...
-
https://arthritis-re...
-
https://lup.lub.lu.s...
-
https://doi.org/10.1...
-
http://kipublication...
-
show less...
Abstract
Subject headings
Close
- Background: In patients with systemic lupus erythematosus (SLE) there is no serological test that will reliably distinguish neuropsychiatric (NP) events due to active SLE from those due to other causes. Previously we showed that serum levels of nitrated nucleosomes (NN) were elevated in a small number of patients with NPSLE. Here we measured serum NN in samples from a larger population of patients with SLE and NP events to see whether elevated serum NN could be a marker for NPSLE. Methods: We obtained serum samples from patients in the Systemic Lupus International Collaborative Clinics (SLICC) inception cohort. This included 216 patients with NP events and two matched controls with SLE but no NP events for each of these patients. For the NP patients we tested samples taken before, during and after the NP event. Results: Twenty-six patients had events attributed to SLE according to the most stringent SLICC attribution rule. In these patients there was no association between onset of event and elevated serum NN. In 190 patients in whom events were not attributed to SLE by the SLICC rules, median serum NN was elevated at the onset of event (P = 0.006). The predominant clinical features in this group of 190 patients were headache, mood disorders and anxiety. Conclusions: Serum NN levels rise at the time of an NP event in a proportion of patients with SLE. Further studies are needed to determine the value of serum NN as a biomarker for NPSLE.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Reumatologi och inflammation (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Rheumatology and Autoimmunity (hsv//eng)
Keyword
- Neuropsychiatric
- Nitration
- Nucleosomes
- Systemic lupus erythematosus
Publication and Content Type
- art (subject category)
- ref (subject category)
Find in a library
To the university's database
- By the author/editor
-
Ferreira, Isabel
-
Croca, Sara
-
Raimondo, Maria ...
-
Matharu, Manjit
-
Miller, Sarah
-
Giles, Ian
-
show more...
-
Isenberg, David
-
Ioannou, Yiannis
-
Hanly, John G.
-
Urowitz, Murray ...
-
Anderson, Nicole
-
Aranow, Cynthia
-
Askanase, Anca
-
Bae, Sang Cheol
-
Bernatsky, Sasha
-
Bruce, Ian N.
-
Buyon, Jill
-
Clarke, Ann E.
-
Dooley, Mary Ann ...
-
Fortin, Paul
-
Ginzler, Ellen
-
Gladman, Dafna
-
Gordon, Caroline
-
Inanc, Murat
-
Jacobsen, Søren
-
Kalunian, Kennet ...
-
Kamen, Diane
-
Khamashta, Munth ...
-
Lim, Sam
-
Manzi, Susan
-
Merrill, Joan
-
Nived, Ola
-
Peschken, Christ ...
-
Petri, Michelle
-
Ramsey-Goldman, ...
-
Ruiz-Irastorza, ...
-
Sanchez-Guerrero ...
-
Steinson, Kristj ...
-
Sturfelt, Gunnar ...
-
van Vollenhoven, ...
-
Wallace, Daniel ...
-
Zoma, Asad
-
Rahman, Anisur
-
show less...
- About the subject
-
- MEDICAL AND HEALTH SCIENCES
-
MEDICAL AND HEAL ...
-
and Clinical Medicin ...
-
and Rheumatology and ...
- Articles in the publication
-
Arthritis Resear ...
- By the university
-
Lund University
-
Karolinska Institutet