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| Fältnamn | Indikatorer | Metadata |
|---|---|---|
| 000 | 03423naa a2200421 4500 | |
| 001 | oai:DiVA.org:uu-260807 | |
| 003 | SwePub | |
| 008 | 150825s2015 | |||||||||||000 ||eng| | |
| 024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-2608072 URI |
| 024 | 7 | a https://doi.org/10.1111/all.126472 DOI |
| 040 | a (SwePub)uu | |
| 041 | a engb eng | |
| 042 | 9 SwePub | |
| 072 | 7 | a ref2 swepub-contenttype |
| 072 | 7 | a art2 swepub-publicationtype |
| 100 | 1 | a Kuitunen, M.4 aut |
| 245 | 1 0 | a High IgE levels to -lactalbumin, -lactoglobulin and casein predict less successful cow's milk oral immunotherapy |
| 264 | c 2015-05-28 | |
| 264 | 1 | b Wiley,c 2015 |
| 338 | a print2 rdacarrier | |
| 520 | a BackgroundA new treatment option for persistent cow's milk allergy (CMA) is oral immunotherapy (OIT). Not all patients develop tolerance during therapy, and markers to identify those who will benefit from it are needed. The objective was to study the IgE and IgG(4) antibody profiles to milk and milk proteins before and after OIT in relation to clinical outcome. MethodsSeventy-six children (5-17years) with challenge-verified CMA were subjected to a 6-month OIT protocol. The treatment aimed at reaching a maintenance dose of 200ml CM (high dose=HD). Those who did not reach target were analysed as a low-dose (LD) group. Sera were characterized before and after OIT regarding serum levels of IgE and IgG(4) to milk and five milk allergen components evaluated together with clinical CMA symptoms and outcome of OIT. ResultsFifty-five (72%) patients reached the maintenance dose (HD) during therapy. High specific IgE levels towards the milk allergens -lactalbumin (P=0.048), -lactoglobulin (P=0.006) and casein (P=0.015) before OIT start were associated with lower maintenance dose reached. Patients who developed desensitization had a larger increase in IgG(4) levels to -lactalbumin (P=0.034), -lactoglobulin (P=0.010), casein (P=0.047) and lactoferrin (P=0.030) during treatment than those who failed. ConclusionsComponent-resolved diagnostics before OIT can help to identify children with lower probability of a successful OIT outcome, as high IgE levels to -lactalbumin, -lactoglobulin and casein are associated with lower maintenance dose reached. An increase in the IgG(4) concentration to milk components during treatment indicated effective desensitization. | |
| 650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Lungmedicin och allergi0 (SwePub)302192 hsv//swe |
| 650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Respiratory Medicine and Allergy0 (SwePub)302192 hsv//eng |
| 653 | a cow's milk allergy | |
| 653 | a desensitization | |
| 653 | a oral immunotherapy | |
| 653 | a specific IgE | |
| 653 | a specific IgG(4) | |
| 700 | 1 | a Englund, H.4 aut |
| 700 | 1 | a Remes, S.4 aut |
| 700 | 1 | a Moverare, Robertu Uppsala universitet,Lungmedicin och allergologi4 aut0 (Swepub:uu)robmo702 |
| 700 | 1 | a Pelkonen, A.4 aut |
| 700 | 1 | a Borres, Magnus P.u Uppsala universitet,Pediatrik4 aut0 (Swepub:uu)magbo385 |
| 700 | 1 | a Makela, M. J.4 aut |
| 710 | 2 | a Uppsala universitetb Lungmedicin och allergologi4 org |
| 773 | 0 | t Allergy. European Journal of Allergy and Clinical Immunologyd : Wileyg 70:8, s. 955-962q 70:8<955-962x 0105-4538x 1398-9995 |
| 856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-260807 |
| 856 | 4 8 | u https://doi.org/10.1111/all.12647 |
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