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Expression of GNAZ,...
Expression of GNAZ, encoding the G alpha(z) protein, predicts survival in mantle cell lymphoma
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- Mundt, Filip (author)
- Broad Inst MIT & Harvard, Prote & Biomarkers, Cambridge, MA 02142 USA
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- Merrien, Magali (author)
- Karolinska Inst, Div Pathol, Dept Lab Med, Stockholm, Sweden
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- Nygren, Lina (author)
- Karolinska Inst, Div Pathol, Dept Lab Med, Stockholm, Sweden
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- Sutton, Lesley Ann (author)
- Uppsala universitet,Institutionen för immunologi, genetik och patologi,Science for Life Laboratory, SciLifeLab,Karolinska Inst, Dept Mol Med & Surg, Stockholm, Sweden
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- Christensson, Birger (author)
- Karolinska Inst, Div Pathol, Dept Lab Med, Stockholm, Sweden
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- Wahlin, Bjorn E. (author)
- Karolinska Inst, Dept Med, Stockholm, Sweden
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- Rosenquist, Richard (author)
- Uppsala universitet,Institutionen för immunologi, genetik och patologi,Science for Life Laboratory, SciLifeLab,Karolinska Inst, Dept Mol Med & Surg, Stockholm, Sweden
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- Sander, Birgitta (author)
- Karolinska Inst, Div Pathol, Dept Lab Med, Stockholm, Sweden
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- Wasik, Agata M. (author)
- Karolinska Inst, Div Pathol, Dept Lab Med, Stockholm, Sweden
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(creator_code:org_t)
- 2019-02-20
- 2019
- English.
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In: British Journal of Haematology. - : WILEY. - 0007-1048 .- 1365-2141. ; 185:4, s. 708-712
- Related links:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Subject headings
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- Mantle cell lymphoma (MCL), a malignancy of B-lymphocytes, has a poor prognosis. It is thus necessary to improve the understanding of the pathobiology of MCL and identify factors contributing to its aggressiveness. Our studies, based on Affymetrix data from 17 MCL biopsies, real-time quantitative polymerase chain reaction data from 18 sorted primary MCL cells and 108 MCL biopsies compared to non-malignant tissue, reveals that GNAZ expression predicts poor clinical outcome of MCL patients (Cox regression, P = 0 center dot 014) and lymphocytosis (Mann-Whitney, P = 0 center dot 011). We show that GNAZ translates to G alpha(z) protein - a signalling molecule within the G-protein coupled receptor network. Our findings suggest that GNAZ/G alpha(z) contribute to the MCL pathobiology.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Hematologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Hematology (hsv//eng)
Keyword
- mantle cell lymphoma
- G-protein coupled receptors
- G-proteins
- prognosis
- lymphocytosis
Publication and Content Type
- ref (subject category)
- art (subject category)
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