WFRF:(Murphy E)
Sökning: WFRF:(Murphy E) > (2000-2004) > Increased serum car...
LIBRIS Formathandbok (Information om MARC21)
| Fältnamn | Indikatorer | Metadata |
|---|---|---|
| 000 | 03634naa a2200361 4500 | |
| 001 | oai:lup.lub.lu.se:5fa3656b-edb8-4d02-9485-503ce76cf21f | |
| 003 | SwePub | |
| 008 | 160401s2002 | |||||||||||000 ||eng| | |
| 024 | 7 | a https://lup.lub.lu.se/record/1106402 URI |
| 024 | 7 | a https://doi.org/10.1136/ard.61.11.9812 DOI |
| 040 | a (SwePub)lu | |
| 041 | a engb eng | |
| 042 | 9 SwePub | |
| 072 | 7 | a art2 swepub-publicationtype |
| 072 | 7 | a ref2 swepub-contenttype |
| 100 | 1 | a Murphy, E4 aut |
| 245 | 1 0 | a Increased serum cartilage oligomeric matrix protein levels and decreased patellar bone mineral density in patients with chondromalacia patellae. |
| 264 | 1 | b BMJ,c 2002 |
| 338 | a electronic2 rdacarrier | |
| 520 | a BACKGROUND: Chondromalacia patellae is a potentially disabling disorder characterised by features of patellar cartilage degradation. OBJECTIVE: To evaluate markers of cartilage and bone turnover in patients with chondromalacia patellae. METHODS: 18 patients with chondromalacia patellae were studied. Serum cartilage oligomeric matrix protein (s-COMP) and bone sialoprotein (s-BSP) levels were measured by enzyme linked immunosorbent assay (ELISA) and compared with those of age and sex matched healthy control subjects. Periarticular bone mineral density (BMD) of both knee joints was assessed by dual energy x ray absorptiometry (DXA). RESULTS: s-COMP levels were significantly raised in all patients with chondromalacia patellae compared with healthy control subjects (p=0.0001). s-BSP levels did not differ significantly between the groups (p=0.41). BMD of the patella was significantly reduced in patients with chondromalacia patellae compared with the control subjects (p=0.016). In patients with bilateral chondromalacia patellae, BMD of the patella was lower in the more symptomatic knee joint (p=0.005). Changes in periarticular BMD were localised to the patella and were not present in femoral regions. Neither s-COMP (p=0.18) nor s-BSP (p=0.40) levels correlated with patellar BMD. CONCLUSIONS: Increased s-COMP levels, reflecting cartilage degradation, and reduced BMD localised to the patella may represent clinically useful markers in the diagnosis and monitoring of patients with chondromalacia patellae. Measures of cartilage degradation did not correlate with loss of patellar bone density, suggesting dissociated pathophysiological mechanisms. | |
| 650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Reumatologi och inflammation0 (SwePub)302102 hsv//swe |
| 650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Rheumatology and Autoimmunity0 (SwePub)302102 hsv//eng |
| 700 | 1 | a FitzGerald, O4 aut |
| 700 | 1 | a Saxne, Toreu Lund University,Lunds universitet,Reumatologi och molekylär skelettbiologi,Sektion III,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Rheumatology,Section III,Department of Clinical Sciences, Lund,Faculty of Medicine4 aut0 (Swepub:lu)reum-tsa |
| 700 | 1 | a Bresnihan, B4 aut |
| 710 | 2 | a Reumatologi och molekylär skelettbiologib Sektion III4 org |
| 773 | 0 | t Annals of the Rheumatic Diseasesd : BMJg 61:11, s. 981-985q 61:11<981-985x 1468-2060x 0003-4967 |
| 856 | 4 | u https://portal.research.lu.se/files/4734048/623665.pdfx primaryx freey FULLTEXT |
| 856 | 4 | u http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=12379520&dopt=Abstractx freey FULLTEXT |
| 856 | 4 | u http://dx.doi.org/10.1136/ard.61.11.981x freey FULLTEXT |
| 856 | 4 | u https://ard.bmj.com/content/61/11/981.full.pdf |
| 856 | 4 8 | u https://lup.lub.lu.se/record/110640 |
| 856 | 4 8 | u https://doi.org/10.1136/ard.61.11.981 |
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- Murphy, E
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