SwePub
Sök i LIBRIS databas

  Utökad sökning

WFRF:(Nerpin Elisabet)
 

Sökning: WFRF:(Nerpin Elisabet) > (2020-2024) > Cardiovascular dise...

LIBRIS Formathandbok  (Information om MARC21)
FältnamnIndikatorerMetadata
00007156naa a2200685 4500
001oai:DiVA.org:uu-499944
003SwePub
008230405s2023 | |||||||||||000 ||eng|
009oai:DiVA.org:du-45839
009oai:lup.lub.lu.se:8f09c38e-b0c1-4c63-bf1f-4e43b679d79a
009oai:prod.swepub.kib.ki.se:152429377
0247 a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-4999442 URI
0247 a https://doi.org/10.1183/23120541.00321-20222 DOI
0247 a https://urn.kb.se/resolve?urn=urn:nbn:se:du-458392 URI
0247 a https://lup.lub.lu.se/record/8f09c38e-b0c1-4c63-bf1f-4e43b679d79a2 URI
0247 a http://kipublications.ki.se/Default.aspx?queryparsed=id:1524293772 URI
040 a (SwePub)uud (SwePub)dud (SwePub)lud (SwePub)ki
041 a engb eng
042 9 SwePub
072 7a ref2 swepub-contenttype
072 7a art2 swepub-publicationtype
1001 a Rydell, Andreasu Karolinska Institutet,Karolinska Institute4 aut
2451 0a Cardiovascular disease-linked plasma proteins are mainly associated with lung volume
264 c 2023-01-26
264 1b European Respiratory Society,c 2023
338 a electronic2 rdacarrier
520 a BACKGROUND: Epidemiological studies have shown that impaired lung function is common and associated with increased risk of cardiovascular disease. Increased levels of several inflammatory and cardiovascular disease-related plasma proteins have been associated with impaired lung function. The aim was to study the association between plasma proteomics and forced expiratory volume in 1 s (FEV1), forced vital capacity (FVC) and FEV1/FVC ratio.METHODS: We used a discovery and replication approach in two community-based cohorts, EpiHealth and the Malmö Offspring Study (total n=2874), to cross-sectionally study 242 cardiovascular disease- and metabolism-linked proteins in relation to FEV1, FVC (both % predicted) and FEV1/FVC ratio. A false discovery rate of 5% was used as the significance threshold in the discovery cohort.RESULTS: Plasma fatty acid-binding protein 4, interleukin-1 receptor antagonist, interleukin-6 and leptin were negatively associated with FEV1 and paraoxonase 3 was positively associated therewith. Fatty acid-binding protein 4, fibroblast growth factor 21, interleukin-1 receptor antagonist, interleukin-6 and leptin were negatively associated with FVC and agouti-related protein, insulin-like growth factor-binding protein 2, paraoxonase 3 and receptor for advanced glycation end products were positively associated therewith. No proteins were associated with FEV1/FVC ratio. A sensitivity analysis in EpiHealth revealed only minor changes after excluding individuals with known cardiovascular disease, diabetes or obesity.CONCLUSIONS: Five proteins were associated with both FEV1 and FVC. Four proteins associated with only FVC and none with FEV1/FVC ratio, suggesting associations mainly through lung volume, not airway obstruction. However, additional studies are needed to investigate underlying mechanisms for these findings.
650 7a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Lungmedicin och allergi0 (SwePub)302192 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Respiratory Medicine and Allergy0 (SwePub)302192 hsv//eng
650 7a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Kardiologi0 (SwePub)302062 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Cardiac and Cardiovascular Systems0 (SwePub)302062 hsv//eng
653 a Lung Medicine
653 a Lungmedicin
653 a Physiology
653 a Fysiologi
7001 a Nerpin, Elisabet,d 1962-u Dalarna University College,Högskolan Dalarna,Uppsala universitet,Lung- allergi- och sömnforskning,School of Health and Welfare, Dalarna University,Medicinsk vetenskap,Uppsala University, Uppsala4 aut0 (Swepub:du)ene
7001 a Zhou, Xingwuu Uppsala universitet,Institutionen för medicinska vetenskaper,Uppsala University, Uppsala4 aut0 (Swepub:uu)xinzh435
7001 a Lind, Larsu Uppsala universitet,Klinisk epidemiologi,Uppsala University, Uppsala4 aut0 (Swepub:uu)larslind
7001 a Lindberg, Evau Uppsala universitet,Lung- allergi- och sömnforskning,Uppsala University, Uppsala4 aut0 (Swepub:uu)evalb
7001 a Theorell-Haglöw, Jennyu Uppsala universitet,Lung- allergi- och sömnforskning,Uppsala University, Uppsala4 aut0 (Swepub:uu)jethe020
7001 a Fall, Tove,d 1979-u Uppsala universitet,Molekylär epidemiologi,Uppsala University, Uppsala4 aut0 (Swepub:uu)tovfa878
7001 a Janson, Christeru Uppsala universitet,Lung- allergi- och sömnforskning,Uppsala University, Uppsala4 aut0 (Swepub:uu)chrisjn
7001 a Lisspers, Karin,c Docent,d 1954-u Uppsala universitet,Allmänmedicin och preventivmedicin,Uppsala University, Uppsala4 aut0 (Swepub:uu)kalis120
7001 a Elmståhl, Sölveu Lund University,Lunds universitet,Geriatrik,Forskargrupper vid Lunds universitet,Geriatrics,Lund University Research Groups4 aut0 (Swepub:lu)smi-sel
7001 a Zaigham, Suneelau Lund University,Lunds universitet,Uppsala universitet,Klinisk fysiologi,Department of Clinical Sciences, Lund University,Uppsala University, Uppsala; Lund University, Malmö,Kardiovaskulär forskning - epidemiologi,Forskargrupper vid Lunds universitet,Cardiovascular Research - Epidemiology,Lund University Research Groups4 aut0 (Swepub:lu)med-sez
7001 a Melander, Olleu Lund University,Lunds universitet,Kardiovaskulär forskning - hypertoni,Forskargrupper vid Lunds universitet,Cardiovascular Research - Hypertension,Lund University Research Groups,Skåne University Hospital4 aut0 (Swepub:lu)endo-ome
7001 a Nilsson, Peter M.u Lund University,Lunds universitet,Internmedicin - epidemiologi,Forskargrupper vid Lunds universitet,Internal Medicine - Epidemiology,Lund University Research Groups4 aut0 (Swepub:lu)medf-pni
7001 a Ärnlöv, Johan,d 1970-u Karolinska Institute,Dalarna University College,Högskolan Dalarna,Medicinsk vetenskap,Karolinska Institutet, Huddinge; Region Dalarna, Falun4 aut0 (Swepub:du)jan
7001 a Malinovschi, Andrei,d 1978-u Uppsala universitet,Klinisk fysiologi,Uppsala University, Uppsala4 aut0 (Swepub:lu)an6820ma
7102 a Karolinska Institutetb Karolinska Institute4 org
7730 t ERJ Open Researchd : European Respiratory Societyg 9:2q 9:2x 2312-0541
8564 u https://doi.org/10.1183/23120541.00321-2022y Fulltext
8564 u https://uu.diva-portal.org/smash/get/diva2:1749069/FULLTEXT01.pdfx primaryx Raw objecty fulltext:print
8564 u https://du.diva-portal.org/smash/get/diva2:1749850/FULLTEXT01.pdfx primaryx Raw objecty fulltext:print
8564 u http://dx.doi.org/10.1183/23120541.00321-2022x freey FULLTEXT
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-499944
8564 8u https://doi.org/10.1183/23120541.00321-2022
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:du-45839
8564 8u https://lup.lub.lu.se/record/8f09c38e-b0c1-4c63-bf1f-4e43b679d79a
8564 8u http://kipublications.ki.se/Default.aspx?queryparsed=id:152429377

Hitta via bibliotek

Till lärosätets databas

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

 
pil uppåt Stäng

Kopiera och spara länken för att återkomma till aktuell vy